Zobrazeno 1 - 10 of 1 023 pro vyhledávání: '"J, Skalicky"'
1
Akademický článek
The Calpain-7 protease functions together with the ESCRT-III protein IST1 within the midbody to regulate the timing and completion of abscission
Autor: Elliott L Paine, Jack J Skalicky, Frank G Whitby, Douglas R Mackay, Katharine S Ullman, Christopher P Hill, Wesley I Sundquist
Publikováno v: eLife, Vol 12 (2023)
The Endosomal Sorting Complexes Required for Transport (ESCRT) machinery mediates the membrane fission step that completes cytokinetic abscission and separates dividing cells. Filaments composed of ESCRT-III subunits constrict membranes of the interc
Externí odkaz: https://doaj.org/article/2fc3d4be4cff4d3e80b6e77ad5bf983b
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2
Akademický článek
Comprehensive analysis of the human ESCRT-III-MIT domain interactome reveals new cofactors for cytokinetic abscission
Autor: Dawn M Wenzel, Douglas R Mackay, Jack J Skalicky, Elliott L Paine, Matthew S Miller, Katharine S Ullman, Wesley I Sundquist
Publikováno v: eLife, Vol 11 (2022)
The 12 related human ESCRT-III proteins form filaments that constrict membranes and mediate fission, including during cytokinetic abscission. The C-terminal tails of polymerized ESCRT-III subunits also bind proteins that contain Microtubule-Interacti
Externí odkaz: https://doaj.org/article/cc5c47a4664040128fa579ea2adf3aa6
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5
The Calpain-7 protease functions together with the ESCRT-III protein IST1 within the midbody to regulate the timing and completion of abscission
Autor: Elliott L. Paine, Jack J. Skalicky, Frank G. Whitby, Douglas R. Mackay, Katharine S. Ullman, Christopher P. Hill, Wesley I. Sundquist
The Endosomal Sorting Complexes Required for Transport (ESCRT) machinery mediates the membrane fission step that completes cytokinetic abscission and separates dividing cells. Filaments composed of ESCRT-III subunits constrict membranes of the interc
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5da5714884e80fb696494f6ec8eef075
https://doi.org/10.1101/2022.10.18.512775
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7
Discovery of Methylene Thioacetal-Incorporated α-RgIA Analogues as Potent and Stable Antagonists of the Human α9α10 Nicotinic Acetylcholine Receptor for the Treatment of Neuropathic Pain
Autor: Jack J. Skalicky, Cheryl Dowell, Sean Christensen, Landa Purushottam, Danny Hung-Chieh Chou, Nan Zheng, J. Michael McIntosh
Publikováno v: J Med Chem
The α9-containing nicotinic acetylcholine receptors (nAChRs) are key targets for the treatment of neuropathic pain. α-Conotoxin RgIA4 is a peptide antagonist of human α9α10 nAChRs with high selectivity. However, structural rearrangement reveals a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dca0f852f0630cbe7e84e18cc38c19f5
https://doi.org/10.1021/acs.jmedchem.1c00802
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8
Akademický článek
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9
Mutations of Rad6 E2 ubiquitin-conjugating enzymes at alanine-126 in helix-3 affect ubiquitination activity and decrease enzyme stability
Autor: Prakash K. Shukla, Dhiraj Sinha, Andrew M. Leng, Jesse E. Bissell, Shravya Thatipamula, Rajarshi Ganguly, Kaitlin S. Radmall, Jack J. Skalicky, Dennis C. Shrieve, Mahesh B. Chandrasekharan
Publikováno v: The Journal of biological chemistry. 298(11)
Rad6, an E2 ubiquitin-conjugating enzyme conserved from yeast to humans, functions in transcription, genome maintenance, and proteostasis. The contributions of many conserved secondary structures of Rad6 and its human homologs UBE2A and UBE2B to thei
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a74e3691a604e8100df6828ee87475a
https://pubmed.ncbi.nlm.nih.gov/36162503
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