Výsledky vyhledávání - "J, Settleman"

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Differing structural requirements for GTPase-activating protein responsiveness and NADPH oxidase activation by Rac

Autor: Martin A. Schwartz, J. Settleman, D. C. Barry, Gary M. Bokoch, Xuemin Xu

Publikováno v: Scopus-Elsevier

The Rac GTP-binding proteins regulate the actin cytoskeleton and the superoxide-forming NADPH oxidase of phagocytic leukocytes. These functions of Rac are determined by the GTP/GDP state of the protein, which can be modulated by GTPase-activating pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d1c0202035258c4102a8e74dabbcf9d
https://doi.org/10.1016/s0021-9258(17)31553-3

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Regulation of NADPH oxidase activity by Rac GTPase activating protein(s)

Autor: J Settleman, John T. Curnutte, Ulla G. Knaus, Paul G. Heyworth, Gary M. Bokoch

Publikováno v: Molecular Biology of the Cell. 4:1217-1223

Activation of the NADPH oxidase of phagocytic cells requires the action of Rac2 or Rac1, members of the Ras superfamily of GTP-binding proteins. Rac proteins are active when in the GTP-bound form and can be regulated by a variety of proteins that mod

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbfa26542fb31daa6e06de14a61ce80a
https://doi.org/10.1091/mbc.4.11.1217

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The N-terminal region of GAP regulates cytoskeletal structure and cell adhesion

Autor: Geraldine Mbamalu, M. Rozakis-Adcock, D. Anderson, J. Settleman, Lan Bo Chen, B. Brunkhorst, S. Dedhar, J McGlade, Tony Pawson

Publikováno v: The EMBO Journal. 12:3073-3081

Ras GTPase activating protein (GAP) possesses a C-terminal domain that interacts with GTP-bound Ras, and an N-terminal region containing two SH2 domains and an SH3 domain. In addition to its association with Ras, GAP binds stably to autophosphorylate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0464b9901176eda6bc0795fc22b86ff6
https://doi.org/10.1002/j.1460-2075.1993.tb05976.x

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Rac 'n Rho: the music that shapes a developing embryo

Autor: J, Settleman

Publikováno v: Developmental cell. 1(3)

The small GTPases of the Rho subfamily constitute a group of evolutionarily conserved proteins that mediate signaling pathways that regulate a variety of cellular processes, many of which are associated with dynamic cytoskeletal reorganization. These

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ef38b57870f85d611a41eed960ccb571
https://pubmed.ncbi.nlm.nih.gov/11702944

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MEK kinase 2 binds and activates protein kinase C-related kinase 2. Bifurcation of kinase regulatory pathways at the level of an MAPK kinase kinase

Autor: W, Sun, S, Vincent, J, Settleman, G L, Johnson

Publikováno v: The Journal of biological chemistry. 275(32)

MEK kinase 2 (MEKK2) is a 70-kDa protein serine/threonine kinase that has been shown to function as a mitogen-activated protein kinase (MAPK) kinase kinase. MEKK2 has its kinase domain in the COOH-terminal moiety of the protein. The NH(2)-terminal mo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bb0d678e4e3f18448bfd5647f0f9bb34
https://pubmed.ncbi.nlm.nih.gov/10818102

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Rho GTPases in development

Autor: J, Settleman

Publikováno v: Progress in molecular and subcellular biology. 22

It is becoming increasingly clear that the complex family of Rho-related GTPases and their associated regulators and targets are essential mediators of a variety of morphogenetic events required for normal development of multicellular organisms. It i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b035bfc9489357d6aa927060a02ae079
https://pubmed.ncbi.nlm.nih.gov/10081071

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Activation of the c-fos serum response element by phosphatidyl inositol 3-kinase and rho pathways in HeLa cells

Autor: Y, Wang, M, Falasca, J, Schlessinger, S, Malstrom, P, Tsichlis, J, Settleman, W, Hu, B, Lim, R, Prywes

Publikováno v: Cell growthdifferentiation : the molecular biology journal of the American Association for Cancer Research. 9(7)

Many growth factors rapidly induce transcription of the c-fos proto-oncogene. We have investigated the pathways for induction of the c-fos promoter by serum and epidermal growth factor (EGF) in HeLa cells. Induction of the serum response element (SRE

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d27830c73bb87224f761245f08efcbe8
https://pubmed.ncbi.nlm.nih.gov/9690619

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