Zobrazeno 1 - 10
of 6 141
pro vyhledávání: '"J, SCHWARZ"'
Autor:
Masaki Takasugi, Yoshiki Nonaka, Kazuaki Takemura, Yuya Yoshida, Frank Stein, Jennifer J. Schwarz, Jun Adachi, Junko Satoh, Shinji Ito, Gregory Tombline, Seyed Ali Biashad, Andrei Seluanov, Vera Gorbunova, Naoko Ohtani
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract To what extent and how post-transcriptional dysregulation affects aging proteome remains unclear. Here, we provide proteomic data of whole-tissue lysates (WTL) and low-solubility protein-enriched fractions (LSF) of major tissues collected fr
Externí odkaz:
https://doaj.org/article/ad6e07f0f47841f7905053022225202d
Autor:
Mario Tranfa, Luigi Lorenzini, Lyduine E. Collij, David Vállez García, Silvia Ingala, Giuseppe Pontillo, Leonard Pieperhoff, Alessio Maranzano, Robin Wolz, Sven Haller, Kaj Blennow, Giovanni Frisoni, Carole H. Sudre, Gael Chételat, Michael Ewers, Pierre Payoux, Adam Waldman, Pablo Martinez‐Lage, Adam J. Schwarz, Craig W. Ritchie, Joanna M. Wardlaw, Juan Domingo Gispert, Arturo Brunetti, Henk J. M. M. Mutsaerts, Alle Meije Wink, Frederik Barkhof
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 11, Iss 6, Pp 1541-1556 (2024)
Abstract Objective Alzheimer's disease (AD) and cerebral small vessel disease (cSVD), the two most common causes of dementia, are characterized by white matter (WM) alterations diverging from the physiological changes occurring in healthy aging. Diff
Externí odkaz:
https://doaj.org/article/e26e34b52bc34c948ba296d241f25394
Publikováno v:
Neurology Perspectives, Vol 4, Iss , Pp 328-329 (2024)
Externí odkaz:
https://doaj.org/article/67132ae0b10445a4b9abaef7a330514d
Autor:
Joseph Balnis, Andy Madrid, Lisa A. Drake, Rachel Vancavage, Anupama Tiwari, Vraj J. Patel, Ramon Bossardi Ramos, John J. Schwarz, Recai Yucel, Harold A. Singer, Reid S. Alisch, Ariel Jaitovich
Publikováno v:
EBioMedicine, Vol 106, Iss , Pp 105251- (2024)
Summary: Background: DNA methylation integrates environmental signals with transcriptional programs. COVID-19 infection induces changes in the host methylome. While post-acute sequelae of COVID-19 (PASC) is a long-term complication of acute illness,
Externí odkaz:
https://doaj.org/article/fbb65d32c5c74a52a39bd435d43f1d81
Autor:
Lindsay McGregor, Samira Acajjaoui, Ambroise Desfosses, Melissa Saïdi, Maria Bacia-Verloop, Jennifer J. Schwarz, Pauline Juyoux, Jill von Velsen, Matthew W. Bowler, Andrew A. McCarthy, Eaazhisai Kandiah, Irina Gutsche, Montserrat Soler-Lopez
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract The Mitochondrial Complex I Assembly (MCIA) complex is essential for the biogenesis of respiratory Complex I (CI), the first enzyme in the respiratory chain, which has been linked to Alzheimer’s disease (AD) pathogenesis. However, how MCIA
Externí odkaz:
https://doaj.org/article/c29c9743fb3e4905b4dd0d556b2b414d
Autor:
Mihir R. Atreya, Natalie Z. Cvijanovich, Julie C. Fitzgerald, Scott L. Weiss, Michael T. Bigham, Parag N. Jain, Adam J. Schwarz, Riad Lutfi, Jeffrey Nowak, Geoffrey L. Allen, Neal J. Thomas, Jocelyn R. Grunwell, Torrey Baines, Michael Quasney, Bereketeab Haileselassie, Matthew N. Alder, Stuart L. Goldstein, Natalja L. Stanski
Publikováno v:
Critical Care, Vol 27, Iss 1, Pp 1-11 (2023)
Abstract Background Sepsis-associated acute kidney injury (SA-AKI) is associated with high morbidity, with no current therapies available beyond continuous renal replacement therapy (CRRT). Systemic inflammation and endothelial dysfunction are key dr
Externí odkaz:
https://doaj.org/article/4523287bf76847e48b73adaa484e2b17
Autor:
Mihir R. Atreya, Shayantan Banerjee, Andrew J. Lautz, Matthew N. Alder, Brian M. Varisco, Hector R. Wong, Jennifer A. Muszynski, Mark W. Hall, L. Nelson Sanchez-Pinto, Rishikesan Kamaleswaran, Natalie Z. Cvijanovich, Julie C. Fitzgerald, Scott L. Weiss, Michael T. Bigham, Parag N. Jain, Adam J. Schwarz, Riad Lutfi, Jeffrey Nowak, Geoffrey L. Allen, Neal J. Thomas, Jocelyn R. Grunwell, Torrey Baines, Michael Quasney, Bereketeab Haileselassie, Chris J. Lindsell
Publikováno v:
EBioMedicine, Vol 99, Iss , Pp 104938- (2024)
Summary: Background: Multiple organ dysfunction syndrome (MODS) disproportionately drives morbidity and mortality among critically ill patients. However, we lack a comprehensive understanding of its pathobiology. Identification of genes associated wi
Externí odkaz:
https://doaj.org/article/162e22e81e7c4a51b9298a80581e6c4c
Autor:
Mihir R. Atreya, Natalie Z. Cvijanovich, Julie C. Fitzgerald, Scott L. Weiss, Michael T. Bigham, Parag N. Jain, Adam J. Schwarz, Riad Lutfi, Jeffrey Nowak, Geoffrey L. Allen, Neal J. Thomas, Jocelyn R. Grunwell, Torrey Baines, Michael Quasney, Bereketeab Haileselassie, Matthew N. Alder, Patrick Lahni, Scarlett Ripberger, Adesuwa Ekunwe, Kyle R. Campbell, Keith R. Walley, Stephen W. Standage
Publikováno v:
Critical Care, Vol 27, Iss 1, Pp 1-12 (2023)
Abstract Background Sepsis is associated with significant mortality. Yet, there are no efficacious therapies beyond antibiotics. PCSK9 loss-of-function (LOF) and inhibition, through enhanced low-density lipoprotein receptor (LDLR) mediated endotoxin
Externí odkaz:
https://doaj.org/article/f5f9c595a1074237837d943ff4b74a9f
Autor:
Y. Tang, P. C. Campbell, P. Lee, R. Saylor, F. Yang, B. Baker, D. Tong, A. Stein, J. Huang, H.-C. Huang, L. Pan, J. McQueen, I. Stajner, J. Tirado-Delgado, Y. Jung, M. Yang, I. Bourgeois, J. Peischl, T. Ryerson, D. Blake, J. Schwarz, J.-L. Jimenez, J. Crawford, G. Diskin, R. Moore, J. Hair, G. Huey, A. Rollins, J. Dibb, X. Zhang
Publikováno v:
Geoscientific Model Development, Vol 15, Pp 7977-7999 (2022)
The latest operational National Air Quality Forecast Capability (NAQFC) has been advanced to use the Community Multiscale Air Quality (CMAQ) model (version 5.3.1) with the CB6r3 (Carbon Bond 6 revision 3) AERO7 (version 7 of the aerosol module) chemi
Externí odkaz:
https://doaj.org/article/e76cf64781a04ab6818afaa3a1e4a643
Autor:
Tanya Novak, Jeremy Chase Crawford, Georg Hahn, Mark W. Hall, Simone A. Thair, Margaret M. Newhams, Janet Chou, Peter M. Mourani, Keiko M. Tarquinio, Barry Markovitz, Laura L. Loftis, Scott L. Weiss, Renee Higgerson, Adam J. Schwarz, Neethi P. Pinto, Neal J. Thomas, Rainer G. Gedeit, Ronald C. Sanders, Sidharth Mahapatra, Bria M. Coates, Natalie Z. Cvijanovich, Kate G. Ackerman, David W. Tellez, Patrick McQuillen, Stephen C. Kurachek, Steven L. Shein, Christoph Lange, Paul G. Thomas, Adrienne G. Randolph
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundInfluenza virus is responsible for a large global burden of disease, especially in children. Multiple Organ Dysfunction Syndrome (MODS) is a life-threatening and fatal complication of severe influenza infection.MethodsWe measured RNA expres
Externí odkaz:
https://doaj.org/article/1b310ffd8aa249aa92844aef701a6cc3