Zobrazeno 1 - 10
of 34
pro vyhledávání: '"J, Robe"'
Autor:
Rebeca Uceda-Castro, Jessy V. van Asperen, Claire Vennin, Jacqueline A. Sluijs, Emma J. van Bodegraven, Andreia S. Margarido, Pierre A. J. Robe, Jacco van Rheenen, Elly M. Hol
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Glioma is the most common form of malignant primary brain tumours in adults. Their highly invasive nature makes the disease incurable to date, emphasizing the importance of better understanding the mechanisms driving glioma invasion. Glial f
Externí odkaz:
https://doaj.org/article/b501743dc3ad44f6bf599962b165fe6f
Autor:
Tuane L Carvalho, Juliana Cordeiro, Jeferson Vizentin-Bugoni, Pedro M Fonseca, Elgion L S Loreto, Lizandra J Robe
Publikováno v:
Genome Biology and Evolution. 15
Understanding the mechanisms that shape the architecture, diversity, and adaptations of genomes and their ecological and genetic interfaces is of utmost importance to understand biological evolution. Transposable elements (TEs) play an important role
Autor:
A T J van der Boog, S David, S H J Nagtegaal, D E Bruil, F Cialdella, T Snijders, P A J Robe, J J C Verhoeff
Publikováno v:
Neuro-Oncology. 24:ii74-ii74
Background For diffuse glioma, tumor location is an important factor that influences symptomatology, treatment strategy and, ultimately, survival. Our previous research showed an association between overall survival (OS) and local involvement in eloq
Publikováno v:
Liver International. 26:406-413
Background: Autoantibody responses reactive with the E2 and E3BP components of pyruvate dehydrogenase complex (PDC), which characterise primary biliary cirrhosis (PBC) crossreact, precluding the identification, from serological studies, of the antige
Publikováno v:
Hepatology. 41:1106-1112
The key immunological event in the pathogenesis of the autoimmune liver disease primary biliary cirrhosis is breakdown of T-cell self-tolerance to pyruvate dehydrogenase complex (PDC). The mechanism resulting in this breakdown of tolerance remains un
Publikováno v:
Hepatology. 39:1583-1592
The autoimmune liver disease primary biliary cirrhosis (PBC) is characterized by the breakdown of normal immune self tolerance to pyruvate dehydrogenase complex (PDC). How tolerance is broken to such a central and highly conserved self antigen in the
Akademický článek
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Autor:
Amanda J. Robe, Jeremy M. Palmer, David Jones, Alastair D. Burt, John A. Kirby, Claire Walker
Publikováno v:
Hepatology. 36:679-686
Bacterial DNA containing unmethylated CpG dinucleotide motifs is immunostimulatory to mammals, skewing CD4(+) T-cell responses toward the Th1 phenotype. Autoreactive T-cell responses seen in primary biliary cirrhosis (PBC) are typically of the Th1 ph
Akademický článek
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Publikováno v:
Autoimmunity. 35(8)
Primary biliary cirrhosis (PBC) is characterised by immune-mediated damage to the intra-hepatic biliary epithelial cells (BEC). Immuno-modulatory/suppressive therapy represents, therefore, alogical approach to treatment in this disease. Conventional