Zobrazeno 1 - 10
of 227
pro vyhledávání: '"J, Radziuk"'
Publikováno v:
Diabetes & Metabolism. 29:163-170
Summary Objectives To analyze, in acute renal failure (ARF) in diabetic rats, how moderate functional ARF would modify metformin (MET) pharmacokinetics and if plasma and renal tissue MET accumulation could aggravate renal insufficiency and/or elicit
Autor:
J. Radziuk, Z. Zhang
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 281:E1240-E1248
The interaction of insulin with metformin on muscle glucose metabolism was examined in the perfused rat hindquarter. Glucose, lactate, and insulin were measured at the inflow to and outflow from the hindquarter, which was perfused with human erythroc
Autor:
J. Radziuk
Publikováno v:
Journal of Clinical Endocrinology & Metabolism. 85:4426-4433
Autor:
Richard D. DiMarchi, B. Bradley, Ronald E. Chance, J. Braaten, J. Radziuk, Ronald R. Bowsher, S. Pye, P. Roach, L. Vignati
Publikováno v:
Diabetologia. 41:116-120
[Ne-palmitoyl Lys (B29)] human insulin is a fatty acid-acylated derivative of insulin with extended action compared to unmodified insulin when infused intravenously (i. v.) secondary to its binding to circulating albumin. The duration and activity pr
Autor:
J. Radziuk, B. Candas
Publikováno v:
IEEE Transactions on Biomedical Engineering. 41:116-124
The design of plasma glucose controllers traditionally relies on linear approaches. The implementation of an appropriate nonlinear model of the insulin/glucose regulatory system into an adaptive controller should predict the insulin-dependent glucose
Publikováno v:
Metabolism. 42:145-153
These studies were designed to calculate the fractional disappearance rate (FDR) and splanchnic extraction of insulin in response to an exogenous (intraperitoneal) input of insulin. A double-tracer technique using insulin tritiated on both the A1 and
Autor:
J, Radziuk, W P, Lee
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 277:E414-E416
the purpose of this discussion in Physiology Forum was to compare two sets of equations for the measurement of the rate of gluconeogenesis (or the fractional gluconeogenetic rate), which had previously been introduced by Drs. J. Katz and J. A. Tayek
Autor:
J. Radziuk, S. Pye
Publikováno v:
Diabetologia. 49(7)
An increase in endogenous glucose production (EGP) is a major contributor to fasting morning hyperglycaemia in type 2 diabetes. This increase is dissipated with fasting, later in the day. To understand its origin, EGP, gluconeogenesis and hormones th
Autor:
J. Radziuk, B. Candas
Publikováno v:
Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society Volume 13: 1991.
This paper presents an adaptive controller based on a minimal nonlinear model of the insulin/ glucose regulatory system. The past fractional removal rates of plasma glucose are first evaluated. from the net balance between glucose infusion and plasma
Publikováno v:
Diabetologia. 45(8)
The rate of endogenous glucose production (EGP) is important in understanding the pathophysiology of Type II (non-insulin-dependent) diabetes mellitus, the aetiology of its complications, and the identification of potential therapeutic targets. A gre