Zobrazeno 1 - 10
of 1 086
pro vyhledávání: '"J, Oldham"'
Autor:
Judyta Olszewski, Rachael A. Hall, Lisette M. Kootker, Neil J. Oldham, Robert Layfield, Barry Shaw, Leon Derksen, Martijn Manders, Tim Hart, Sarah A. Schrader
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Skeletal remains discovered in Simon’s Town, South Africa, were hypothesised as being associated with a former Dutch East India Company (VOC) hospital. We report a novel combined osteological and biochemical approach to these poorly-preser
Externí odkaz:
https://doaj.org/article/e4b927aed09e4a04a0a659ad303513b9
Autor:
Agata Zubrycka, Charlene Dambire, Laura Dalle Carbonare, Gunjan Sharma, Tinne Boeckx, Kamal Swarup, Craig J. Sturrock, Brian S. Atkinson, Ranjan Swarup, Françoise Corbineau, Neil J. Oldham, Michael J. Holdsworth
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Oxygen is a key signalling component of plant biology, and whilst an oxygen-sensing mechanism was previously described in Arabidopsis thaliana, key features of the associated PLANT CYSTEINE OXIDASE (PCO) N-degron pathway and Group VII ETHYLE
Externí odkaz:
https://doaj.org/article/b0a7bf8d1bb84442a4e0ebb138de7089
Autor:
Nathan M. Holt, Saul Shiffman, Ryan A. Black, Nicholas I. Goldenson, Mark A. Sembower, Michael J. Oldham
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract The harm caused by cigarette smoking is overwhelmingly due to byproducts of tobacco combustion. Electronic Nicotine Delivery Systems (ENDS) provide nicotine to users without combustion, and may support tobacco harm reduction among cigarette
Externí odkaz:
https://doaj.org/article/a1d1d8af0c93470c813ba49115f6aa4d
Autor:
J. Brian Jameson, Jiaming Wang, Patrick C. Bailey, Michael J. Oldham, Cameron R. Smith, Lena N. Jeong, David K. Cook, Austin L. Bates, Sifat Ullah, Alexander S. C. Pennington, I. Gene Gillman
Publikováno v:
Frontiers in Chemistry, Vol 11 (2023)
Literature reports the chemical constituent yields of electronic nicotine delivery systems (ENDS) aerosol collected using a range of aerosol collection strategies. The number of puffs to deplete an ENDS product varies widely, but collections often co
Externí odkaz:
https://doaj.org/article/85c13905fd0145cf99e65acc149bd804
Autor:
David K. Cook, Guy Lalonde, Michael J. Oldham, Jiaming Wang, Austin Bates, Sifat Ullah, Christina Sulaiman, Karen Carter, Candice Jongsma, Gary Dull, I. Gene Gillman
Publikováno v:
Toxics, Vol 12, Iss 1, p 41 (2024)
Electronic nicotine delivery systems (ENDSs) are designed as a non-combustible alternative to cigarettes, aiming to deliver nicotine without the harmful byproducts of tobacco combustion. As the category evolves and new ENDS products emerge, it is imp
Externí odkaz:
https://doaj.org/article/014287086c9c4634b975c7738b885c0e
Publikováno v:
Toxics, Vol 12, Iss 1, p 16 (2023)
Toxicological evaluations of flavor chemicals for use in inhalation products that utilize heat for aerosol generation are complicated because of the potential effect heat may have on the flavor chemical. The objective was to develop a thermal degrada
Externí odkaz:
https://doaj.org/article/034b8297380c4f36b621095b62d46213
Autor:
Khiyam Hussain, Rena Liu, Rosanna C. G. Smith, Kri T. J. Müller, Mohammadmersad Ghorbani, Sofia Macari, Kirstie L. S. Cleary, Robert J. Oldham, Russell B. Foxall, Sonya James, Steven G. Booth, Tom Murray, Lekh N. Dahal, Chantal E. Hargreaves, Robert S. Kemp, Jemma Longley, James Douglas, Hannah Markham, Serena J. Chee, Richard J. Stopforth, Ali Roghanian, Matthew J. Carter, Christian H. Ottensmeier, Bjorn Frendéus, Ramsey I. Cutress, Ruth R. French, Martin J. Glennie, Jonathan C. Strefford, Stephen M. Thirdborough, Stephen A. Beers, Mark S. Cragg
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 41, Iss 1, Pp 1-32 (2022)
Abstract Background Hypoxia is a hallmark of the tumor microenvironment (TME) and in addition to altering metabolism in cancer cells, it transforms tumor-associated stromal cells. Within the tumor stromal cell compartment, tumor-associated macrophage
Externí odkaz:
https://doaj.org/article/4a2581bb496d4f649850cb54190883b9
Autor:
Jennifer C. Okoye, Jeddidiah Bellamy-Carter, Neil J. Oldham, Neil J. Oldfield, Jafar Mahdavi, Panos Soultanas
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 5355-5363 (2022)
Ferric chelates like ferric tyrosinate (TYPLEX) and the closely related ferric quinate (QPLEX) are structural mimics of bacterial siderophores. TYPLEX has been trialled as a feed additive in farming of commercial broilers, reducing Campylobacter load
Externí odkaz:
https://doaj.org/article/eda1545e797f40e4bb545821f72409a0
Autor:
Joshua M. Sopp, Shirley J. Peters, Tania F. Rowley, Robert J. Oldham, Sonya James, Ian Mockridge, Ruth R. French, Alison Turner, Stephen A. Beers, David P. Humphreys, Mark S. Cragg
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Sopp et al describe an approach, which exploits the tailpiece of the naturally multimeric IgM to augment hexamerisation of IgG. Their approach provides a newly engineered format of antibodies for promoting hexamerisation and enhanced complement-depen
Externí odkaz:
https://doaj.org/article/26ae9b2bf9f1415f9ed90dfd8fef8201
Autor:
Richard B. Gillis, Hodaya V. Solomon, Lata Govada, Neil J. Oldham, Vlad Dinu, Shahwar Imran Jiwani, Philemon Gyasi-Antwi, Frank Coffey, Andy Meal, Paul S. Morgan, Stephen E. Harding, John R. Helliwell, Naomi E. Chayen, Gary G. Adams
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract This study concerns glulisine, a rapid-acting insulin analogue that plays a fundamental role in diabetes management. We have applied a combination of methods namely X-ray crystallography, and biophysical characterisation to provide a detaile
Externí odkaz:
https://doaj.org/article/1baf07d48a3740889f7ac839d941f0d3