Zobrazeno 1 - 10
of 160
pro vyhledávání: '"J, Newhouse"'
Autor:
Jennifer Tisoncik-Go, Caleb Stokes, Leanne S. Whitmore, Daniel J. Newhouse, Kathleen Voss, Andrew Gustin, Cheng-Jung Sung, Elise Smith, Jennifer Stencel-Baerenwald, Edward Parker, Jessica M. Snyder, Dennis W. Shaw, Lakshmi Rajagopal, Raj P. Kapur, Kristina M. Adams Waldorf, Michael Gale
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Zika virus (ZikV) infection during pregnancy can cause congenital Zika syndrome (CZS) and neurodevelopmental delay in infants, of which the pathogenesis remains poorly understood. We utilize an established female pigtail macaque maternal-to-
Externí odkaz:
https://doaj.org/article/5738fe70556843ec9ca7594574c778e6
Autor:
Thomas M. Goralski, Lindsay Meyerdirk, Libby Breton, Laura Brasseur, Kevin Kurgat, Daniella DeWeerd, Lisa Turner, Katelyn Becker, Marie Adams, Daniel J. Newhouse, Michael X. Henderson
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract A key hallmark of Parkinson’s disease (PD) is Lewy pathology. Composed of α-synuclein, Lewy pathology is found both in dopaminergic neurons that modulate motor function, and cortical regions that control cognitive function. Recent work ha
Externí odkaz:
https://doaj.org/article/adda231edd6d4dd9bf1d27ea3cc41c46
Autor:
Hyunah Lee, Amelie Metz, Amina McDiarmid, Alish Palmos, Sang H. Lee, Charles J. Curtis, Hamel Patel, Stephen J. Newhouse, Sandrine Thuret
Publikováno v:
Brain, Behavior, & Immunity - Health, Vol 15, Iss , Pp 100286- (2021)
Cell culture models are valuable tools to study biological mechanisms underlying health and disease in a controlled environment. Although their genotype influences their phenotype, subtle genetic variations in cell lines are rarely characterised and
Externí odkaz:
https://doaj.org/article/e3b6a7ace5a94929a731699b7dcb3a5c
Autor:
Alfredo Iacoangeli, Ahmad Al Khleifat, Ashley R. Jones, William Sproviero, Aleksey Shatunov, Sarah Opie-Martin, Alzheimer’s Disease Neuroimaging Initiative, Karen E. Morrison, Pamela J. Shaw, Christopher E. Shaw, Isabella Fogh, Richard J. Dobson, Stephen J. Newhouse, Ammar Al-Chalabi
Publikováno v:
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-7 (2019)
Abstract The expansion of a hexanucleotide repeat GGGGCC in C9orf72 is the most common known cause of ALS accounting for ~ 40% familial cases and ~ 7% sporadic cases in the European population. In most people, the repeat length is 2, but in people wi
Externí odkaz:
https://doaj.org/article/e04f962044f6412cb6a209fcdb58dead
Autor:
A. Iacoangeli, A. Al Khleifat, W. Sproviero, A. Shatunov, A. R. Jones, S. L. Morgan, A. Pittman, R. J. Dobson, S. J. Newhouse, A. Al-Chalabi
Publikováno v:
BMC Bioinformatics, Vol 20, Iss 1, Pp 1-10 (2019)
Abstract Background Next Generation Sequencing (NGS) is a commonly used technology for studying the genetic basis of biological processes and it underpins the aspirations of precision medicine. However, there are significant challenges when dealing w
Externí odkaz:
https://doaj.org/article/f525eb06961c416c86b20c2cd11dbbf9
Autor:
Matthew Traylor, Jemma L Walker, Adele A Corrigan, Monica A Hernandez, Stephen J Newhouse, Amos A Folarin, Hamel Patel, Paul J Ross, Jeremy D Sanderson, James Spicer, Natalie J Prescott, Christopher G Mathew, Anthony M Marinaki, Cathryn M Lewis
Publikováno v:
PLoS ONE, Vol 13, Iss 5, p e0188911 (2018)
Fluoropyrimidines, including 5-fluororacil (5FU) and its pro-drug Capecitabine, are the common treatment for colorectal, breast, neck and head cancers-either as monotherapy or in combination therapy. Adverse reactions (ADRs) to the treatment are comm
Externí odkaz:
https://doaj.org/article/6d940899bc9b491f95fee80b85b2107c
Publikováno v:
Service Science. 13:109-132
Publishing in respected scholarly journals is critical to academic success. However, if journal editorial boards fail to reflect the diversity of thought in a field, worthy work may be overlooked. This study assesses the level of diversity in the edi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::424bff20a000debc88dfd3eae8ae0b1b
https://doi.org/10.1287/serv.2021.0274
https://doi.org/10.1287/serv.2021.0274
Publikováno v:
Royal Society Open Science, Vol 4, Iss 6 (2017)
West Nile virus (WNV) is a widespread arbovirus that imposes a significant cost to both human and wildlife health. WNV exists in a bird-mosquito transmission cycle in which passerine birds act as the primary reservoir host. As a public health concern
Externí odkaz:
https://doaj.org/article/8b3d496ec8d94f2c8dd78495d4e01be3
Autor:
Gursharan Kalsi, Jack Euesden, Jonathan R I Coleman, Francesca Ducci, Fazil Aliev, Stephen J Newhouse, Xiehe Liu, Xiaohong Ma, Yingcheng Wang, David A Collier, Philip Asherson, Tao Li, Gerome Breen
Publikováno v:
PLoS ONE, Vol 11, Iss 12, p e0167388 (2016)
Drug addiction is a costly and recurring healthcare problem, necessitating a need to understand risk factors and mechanisms of addiction, and to identify new biomarkers. To date, genome-wide association studies (GWAS) for heroin addiction have been l
Externí odkaz:
https://doaj.org/article/855ad098b111430ea8d8e6b8934abb3c
Autor:
Lori B. Chibnik, Céline Bellenguez, Philippe Amouyel, Andrew J. Saykin, Alden L. Gross, Shubhabrata Mukherjee, Stephen J. Newhouse, Paul K. Crane, Ryan Koesterer, Jorge L. Del-Aguila, Richard Sherva, Leanne Munsie, Ashley R. Winslow, David A. Bennett, Robert C. Green, Carole Dufouil, Richard Mayeux, John S. K. Kauwe, Carlos Cruchaga, Lindsay A. Farrer
Publikováno v:
Alzheimer's and Dementia
Alzheimer's and Dementia, Elsevier, 2020, 16 (8), pp.1134-1145. ⟨10.1002/alz.12106⟩
Alzheimers Dement
Alzheimer's and Dementia, Elsevier, 2020, 16 (8), pp.1134-1145. ⟨10.1002/alz.12106⟩
Alzheimers Dement
INTRODUCTION Variability exists in the disease trajectories of Alzheimer's disease (AD) patients. We performed a genome-wide association study to examine rate of cognitive decline (ROD) in patients with AD. METHODS We tested for interactions between
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c5ff63a3c79dd207973bb477efe9212
https://doi.org/10.1002/alz.12106
https://doi.org/10.1002/alz.12106