The Role of Ageing and Parenchymal Senescence on Macrophage Function and Fibrosis

Autor: Ross A. Campbell, Marie-Helena Docherty, David A. Ferenbach, Katie J. Mylonas

Publikováno v: Frontiers in Immunology, Vol 12 (2021)

In this review, we examine senescent cells and the overlap between the direct biological impact of senescence and the indirect impact senescence has via its effects on other cell types, particularly the macrophage. The canonical roles of macrophages

Externí odkaz: https://doaj.org/article/249fa13681e14bc2af7e697679e7ee93

Senolytic treatment preserves biliary regenerative capacity lost through cellular senescence during cold storage

Autor: Sofia Ferreira-Gonzalez, Tak Yung Man, Hannah Esser, Rhona Aird, Alastair M. Kilpatrick, Daniel Rodrigo-Torres, Nicholas Younger, Lara Campana, Victoria L. Gadd, Benjamin Dwyer, Niya Aleksieva, Luke Boulter, Mark T. Macmillan, Yinmiao Wang, Katie J. Mylonas, David A. Ferenbach, Timothy J. Kendall, Wei-Yu Lu, Juan Carlos Acosta, Dominic Kurian, Stephen O’Neill, Gabriel C. Oniscu, Jesus M. Banales, Paul J. Krimpenfort, Stuart J. Forbes

Publikováno v: Ferreira-Gonzalez, S, Man, T Y, Esser, H, Aird, R, Kilpatrick, A, Rodrigo Torres, D, Younger, N, Campana, L, Gadd, V, Dwyer, B, Aleksieva, N, Boulter, L, Macmillan, M, Wang, Y, Mylonas, K J, Ferenbach, D A, Kendall, T J, Lu, W-Y, Acosta, J C, Kurian, D, O'Neill, S, Oniscu, G, Banales, J M, Krimpenfort, P & Forbes, S J 2022, ' Senolytic treatment preserves biliary regenerative capacity lost through cellular senescence during cold storage ', Science Translational Medicine, vol. 14, no. 674, eabj4375 . https://doi.org/10.1126/scitranslmed.abj4375

Liver transplantation is the only curative option for patients with end-stage liver disease. Despite improvements in surgical techniques, nonanastomotic strictures (characterized by the progressive loss of biliary tract architecture) continue to occu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::511d4735d36e8e39daf53ab681bc8df9
https://doi.org/10.1126/scitranslmed.abj4375

Indian Hedgehog release from renal epithelia drives local and remote organ fibrosis

Autor: Cuiyan Xin, Bryan R. Conway, Sarah Finnie, Joseph V. Bonventre, Laura Denby, Cyril Carvalho, Julia Wilflingseder, Neil Henderson, Jeremy Hughes, Eoin O'Sullivan, Angela Oliveira Pisco, Michaela Willi, Katie J. Mylonas, David A. Ferenbach

Chronic kidney disease (CKD) and ageing inhibit tissue regeneration and increase risks of organ fibrosis and cardiovascular disease. Increased numbers of leukocytes are present in the circulation and within the kidney of ageing individuals and patien

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4615b28a91782b677f72a3c9921f9261
https://doi.org/10.21203/rs.3.rs-793155/v1

Stromal Cells Covering Omental Fat-Associated Lymphoid Clusters Trigger Formation of Neutrophil Aggregates to Capture Peritoneal Contaminants

Autor: Beth E. P. Henderson, Mark Nixon, Cécile Bénézech, Pete Smith, Lucy H. Jackson-Jones, Marlene Magalhaes, Neil C. Henderson, Ross Dobie, Sonja Vermeren, Matthieu Vermeren, Katie J. Mylonas, Jordan R. Portman, Damian J. Mole, Laura Denby

Publikováno v: Jackson-Jones, L H, Smith, P, Portman, J R, Magalhaes, M S, Mylonas, K J, Vermeren, M M, Nixon, M, Henderson, B E P, Dobie, R, Vermeren, S, Denby, L, Henderson, N C, Mole, D J & Bénézech, C 2020, ' Stromal Cells Covering Omental Fat-Associated Lymphoid Clusters Trigger Formation of Neutrophil Aggregates to Capture Peritoneal Contaminants ', Immunity, vol. 52, no. 4, pp. 700-715.e6 . https://doi.org/10.1016/j.immuni.2020.03.011

The omentum is a visceral adipose tissue rich in fat-associated lymphoid clusters (FALCs) that collects peritoneal contaminants and provides a first layer of immunological defense within the abdomen. Here, we investigated the mechanisms that mediate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84c65b3885bdfeb01d3f48d7f042fb3f
https://pubmed.ncbi.nlm.nih.gov/32294403

The pericardium promotes cardiac repair and remodelling post-myocardial infarction

Autor: Marlene Magalhaes, Marc R. Dweck, Nikhil Joshi, David E. Newby, Lucy H. Jackson-Jones, Katie J. Mylonas, Judith E. Allen, Marco Meloni, Cécile Bénézech, Jack Andrews, Gillian A. Gray

The pericardium is widely recognised for its lubricating and bio-mechanical properties. It also contains fat-associated lymphoid clusters (FALCs) and its immune functions have been widely overlooked. Here we aimed to assess the inflammatory activity

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f3eb423324e4fc8f6ff315d5ba640e5
https://doi.org/10.1101/771154