Zobrazeno 1 - 10
of 106
pro vyhledávání: '"J, Murtha"'
Autor:
Nicolette M. Fonseca, Corinne Maurice-Dror, Cameron Herberts, Wilson Tu, William Fan, Andrew J. Murtha, Catarina Kollmannsberger, Edmond M. Kwan, Karan Parekh, Elena Schönlau, Cecily Q. Bernales, Gráinne Donnellan, Sarah W. S. Ng, Takayuki Sumiyoshi, Joanna Vergidis, Krista Noonan, Daygen L. Finch, Muhammad Zulfiqar, Stacy Miller, Sunil Parimi, Jean-Michel Lavoie, Edward Hardy, Maryam Soleimani, Lucia Nappi, Bernhard J. Eigl, Christian Kollmannsberger, Sinja Taavitsainen, Matti Nykter, Sofie H. Tolmeijer, Emmy Boerrigter, Niven Mehra, Nielka P. van Erp, Bram De Laere, Johan Lindberg, Henrik Grönberg, Daniel J. Khalaf, Matti Annala, Kim N. Chi, Alexander W. Wyatt
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract No consensus strategies exist for prognosticating metastatic castration-resistant prostate cancer (mCRPC). Circulating tumor DNA fraction (ctDNA%) is increasingly reported by commercial and laboratory tests but its utility for risk stratific
Externí odkaz:
https://doaj.org/article/6914ec1e3ba942ee99b1463117270db9
Autor:
Gillian Vandekerkhove, Jean-Michel Lavoie, Matti Annala, Andrew J. Murtha, Nora Sundahl, Simon Walz, Takeshi Sano, Sinja Taavitsainen, Elie Ritch, Ladan Fazli, Antonio Hurtado-Coll, Gang Wang, Matti Nykter, Peter C. Black, Tilman Todenhöfer, Piet Ost, Ewan A. Gibb, Kim N. Chi, Bernhard J. Eigl, Alexander W. Wyatt
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
In metastatic urothelial carcinoma, it has not been established whether circulating tumor DNA (ctDNA) can replace archival primary tissue to assess mutations and biomarkers. Here, the authors show high mutation concordance between ctDNA and tumour ti
Externí odkaz:
https://doaj.org/article/a2f42ea8d98a4db587379bb0ba66d3fe
Autor:
Jean-Michel Lavoie, Gillian Vandekerkhove, Andrew J. Murtha, Gang Wang, Alexander W. Wyatt, Bernhard J. Eigl
Publikováno v:
Urology Case Reports, Vol 39, Iss , Pp 101762- (2021)
The management of metastatic urothelial cancer is rapidly evolving since immune checkpoint inhibitors were introduced. We present the case of a patient with metastatic upper tract urothelial cancer who had a complete response to durvalumab and tremel
Externí odkaz:
https://doaj.org/article/ff2ebdbc93ad43f0bb25309772f79d18
Autor:
Alexander W. Wyatt, Kim N. Chi, Daniel Khalaf, Matti Annala, Kevin Beja, Elena Schönlau, Arshia Beigi, Arkhjamil Angeles, Nicolette M. Fonseca, Gillian Vandekerkhove, Andrew J. Murtha, Elie Ritch, Gang Wang, Amanda Wong, Steven Yip, Simon Fu, Cameron Herberts, Evan Warner
Purpose:DNA damage repair (DDR) defects are common across cancer types and can indicate therapeutic vulnerability. Optimal exploitation of DDR defects in prostate cancer requires new diagnostic strategies and a better understanding of associated clin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4473477859916eea8ed787ed187d7010
https://doi.org/10.1158/1078-0432.c.6530568.v1
https://doi.org/10.1158/1078-0432.c.6530568.v1
Autor:
Alexander W. Wyatt, Kim N. Chi, Matti Annala, Sebastien Hotte, Cristiano Ferrario, Igal Kushnir, Ladan Fazli, Daniel Khalaf, Yulia Loktionova, Kevin Beja, Gillian Vandekerkhove, Andrew J. Murtha, Sinja Taavitsainen, Elena Schönlau, Evan W. Warner, Gang Wang, Cameron Herberts, Simon Y.F. Fu, Elie Ritch
Supplementary Figure 12. Swimmer plot showing overall patient survival from initial cancer diagnosis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac227298eaf265c7c5683d4095b9228d
https://doi.org/10.1158/1078-0432.22474119.v1
https://doi.org/10.1158/1078-0432.22474119.v1
Autor:
Alexander W. Wyatt, Kim N. Chi, Daniel Khalaf, Matti Annala, Kevin Beja, Elena Schönlau, Arshia Beigi, Arkhjamil Angeles, Nicolette M. Fonseca, Gillian Vandekerkhove, Andrew J. Murtha, Elie Ritch, Gang Wang, Amanda Wong, Steven Yip, Simon Fu, Cameron Herberts, Evan Warner
Supplementary Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22f3448ca1bbd5c0f7a69fed7ef2ee11
https://doi.org/10.1158/1078-0432.22480959.v1
https://doi.org/10.1158/1078-0432.22480959.v1
Autor:
Alexander W. Wyatt, Kim N. Chi, Matti Annala, Sebastien Hotte, Cristiano Ferrario, Igal Kushnir, Ladan Fazli, Daniel Khalaf, Yulia Loktionova, Kevin Beja, Gillian Vandekerkhove, Andrew J. Murtha, Sinja Taavitsainen, Elena Schönlau, Evan W. Warner, Gang Wang, Cameron Herberts, Simon Y.F. Fu, Elie Ritch
Purpose:DNA mismatch repair defects (MMRd) and tumor hypermutation are rare and under-characterized in metastatic prostate cancer (mPC). Furthermore, because hypermutated MMRd prostate cancers can respond to immune checkpoint inhibitors, there is an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::821bdea13eeb3ba454b217fa2c652b7c
https://doi.org/10.1158/1078-0432.c.6528684.v1
https://doi.org/10.1158/1078-0432.c.6528684.v1
Autor:
Alexander W. Wyatt, Kim N. Chi, Daniel Khalaf, Matti Annala, Kevin Beja, Elena Schönlau, Arshia Beigi, Arkhjamil Angeles, Nicolette M. Fonseca, Gillian Vandekerkhove, Andrew J. Murtha, Elie Ritch, Gang Wang, Amanda Wong, Steven Yip, Simon Fu, Cameron Herberts, Evan Warner
Supplementary Figures S1-S6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b7f0b1b76b80dc400ba706d67f347b3
https://doi.org/10.1158/1078-0432.22480962.v1
https://doi.org/10.1158/1078-0432.22480962.v1
Autor:
Alexander W. Wyatt, Kim N. Chi, Daniel Khalaf, Matti Annala, Kevin Beja, Elena Schönlau, Arshia Beigi, Arkhjamil Angeles, Nicolette M. Fonseca, Gillian Vandekerkhove, Andrew J. Murtha, Elie Ritch, Gang Wang, Amanda Wong, Steven Yip, Simon Fu, Cameron Herberts, Evan Warner
Supplementary Tables S1-S10
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f3565e30d39349f94756fc40d24f52a
https://doi.org/10.1158/1078-0432.22480956.v1
https://doi.org/10.1158/1078-0432.22480956.v1
Autor:
Alexander W. Wyatt, Kim N. Chi, Matti Annala, Sebastien Hotte, Cristiano Ferrario, Igal Kushnir, Ladan Fazli, Daniel Khalaf, Yulia Loktionova, Kevin Beja, Gillian Vandekerkhove, Andrew J. Murtha, Sinja Taavitsainen, Elena Schönlau, Evan W. Warner, Gang Wang, Cameron Herberts, Simon Y.F. Fu, Elie Ritch
Supplementary Table 1: Somatic mutation count across all samples within meta-cohort. Counts of mutations in all ctDNA positive samples. 95th and 90th percentile are highlighted. Samples are named as a function of their relative mutation count. Supple
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::293767118f38763a57a1fa4f76eaf160
https://doi.org/10.1158/1078-0432.22474089
https://doi.org/10.1158/1078-0432.22474089