Zobrazeno 1 - 10
of 127
pro vyhledávání: '"J, Modlin"'
Autor:
Joshua M. Thiede, Nicholas A. Dillon, Michael D. Howe, Ranee Aflakpui, Samuel J. Modlin, Sven E. Hoffner, Faramarz Valafar, Yusuke Minato, Anthony D. Baughn
Publikováno v:
mBio, Vol 13, Iss 1 (2022)
ABSTRACT Pyrazinamide (PZA) plays a crucial role in first-line tuberculosis drug therapy. Unlike other antimicrobial agents, PZA is active against Mycobacterium tuberculosis only at low pH. The basis for this conditional drug susceptibility remains u
Externí odkaz:
https://doaj.org/article/8ee355f2a62d421f881cdc358d63bc6d
Autor:
Samuel J. Modlin, Afif Elghraoui, Deepika Gunasekaran, Alyssa M. Zlotnicki, Nicholas A. Dillon, Nermeeta Dhillon, Norman Kuo, Cassidy Robinhold, Carmela K. Chan, Anthony D. Baughn, Faramarz Valafar
Publikováno v:
mSystems, Vol 6, Iss 6 (2021)
ABSTRACT Accurate and timely functional genome annotation is essential for translating basic pathogen research into clinically impactful advances. Here, through literature curation and structure-function inference, we systematically update the functi
Externí odkaz:
https://doaj.org/article/d38fb0ef6dbc4db38915e5bc82ff5dd4
Autor:
Samuel J Modlin, Derek Conkle-Gutierrez, Calvin Kim, Scott N Mitchell, Christopher Morrissey, Brian C Weinrick, William R Jacobs, Sarah M Ramirez-Busby, Sven E Hoffner, Faramarz Valafar
Publikováno v:
eLife, Vol 9 (2020)
This study assembles DNA adenine methylomes for 93 Mycobacterium tuberculosis complex (MTBC) isolates from seven lineages paired with fully-annotated, finished, de novo assembled genomes. Integrative analysis yielded four key results. First, methyltr
Externí odkaz:
https://doaj.org/article/37d5410627424a428faabb57a88c4d9b
Publikováno v:
BMC Genomics, Vol 18, Iss 1, Pp 1-14 (2017)
Abstract Background The genetic basis of virulence in Mycobacterium tuberculosis has been investigated through genome comparisons of virulent (H37Rv) and attenuated (H37Ra) sister strains. Such analysis, however, relies heavily on the accuracy of the
Externí odkaz:
https://doaj.org/article/dd3d627a5be441a0a99533e49029ac73
Autor:
Samuel J. Modlin, Mikael Mansjö, Jim Werngren, Chidera M. Ejike, Sven E. Hoffner, Faramarz Valafar
Publikováno v:
Drug Resistance Updates. 68:100959
Autor:
Derek Conkle-Gutierrez, Calvin Kim, Sarah M. Ramirez-Busby, Samuel J. Modlin, Mikael Mansjö, Jim Werngren, Leen Rigouts, Sven E. Hoffner, Faramarz Valafar
Publikováno v:
Antimicrobial agents and chemotherapy
Antimicrob Agents Chemother
Antimicrob Agents Chemother
Point mutations in the rrs gene and the eis promoter are known to confer resistance to the second-line injectable drugs (SLIDs) amikacin (AMK), capreomycin (CAP), and kanamycin (KAN). While mutations in these canonical genes confer the majority of SL
Autor:
Calvin Kim, Derek Conkle-Gutierrez, Leen Rigouts, Samuel J. Modlin, Jim Werngren, Faramarz Valafar, Mikael Mansjö, Sarah M Ramirez-Busby, Sven Hoffner
Point mutations in the rrs gene and eis promoter are known to confer resistance to second-line injectable drugs (SLIDs) amikacin (AMK), capreomycin (CAP), and kanamycin (KAN). While mutations in these canonical genes confer a majority of SLID-resista
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::92930dd40aff164b7deea76081b74869
https://doi.org/10.1101/2021.11.23.469801
https://doi.org/10.1101/2021.11.23.469801
Autor:
Cassidy Robinhold, Samuel J. Modlin, Nermeeta Dhillon, Alyssa M. Zlotnicki, Anthony D. Baughn, Norman Kuo, Afif Elghraoui, Faramarz Valafar, Carmela K. Chan, Nicholas Dillon, Deepika Gunasekaran
Publikováno v:
mSystems
mSystems, Vol 6, Iss 6 (2021)
mSystems, Vol 6, Iss 6 (2021)
Accurate and timely functional genome annotation is essential for translating basic pathogen research into clinically impactful advances. Here, through literature curation and structure-function inference, we systematically update the functional geno
Autor:
Jim Werngren, Faramarz Valafar, Sven E Hoffner, Mikael Mansjö, Tyler Marbach, Samuel J. Modlin
Publikováno v:
Antimicrobial Agents and Chemotherapy
Pyrazinamide (PZA) is a widely used antitubercular chemotherapeutic. Typically, PZA resistance (PZA-R) emerges in Mycobacterium tuberculosis strains with existing resistance to isoniazid and rifampin (i.e., multidrug resistance [MDR]) and is conferre
Autor:
Anthony D. Baughn, Ranee Aflakpui, Faramarz Valafar, Yusuke Minato, Michael D. Howe, Samuel J. Modlin, Sven E Hoffner, Nicholas Dillon, Joshua M. Thiede
Pyrazinamide (PZA) plays a crucial role in first-line tuberculosis drug therapy. Unlike other antimicrobial agents, PZA is only active against Mycobacterium tuberculosis at low pH. The basis for this conditional drug susceptibility remains undefined.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::646d0d71f234f399d21a4f0413630754
https://doi.org/10.1101/2021.02.17.431758
https://doi.org/10.1101/2021.02.17.431758