Zobrazeno 1 - 10
of 436
pro vyhledávání: '"J, Michaelson"'
Autor:
Paolo Manghi, Michele Filosi, Moreno Zolfo, Lucas G. Casten, Albert Garcia-Valiente, Stefania Mattevi, Vitor Heidrich, Davide Golzato, Samuel Perini, Andrew M. Thomas, Simone Montalbano, Samuele Cancellieri, Levi Waldron, Jacob B. Hall, Simon Xu, Natalia Volfovsky, LeeAnne Green Snyder, Pamela Feliciano, Francesco Asnicar, Mireia Valles-Colomer, Jacob J. Michaelson, Nicola Segata, Enrico Domenici
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract The link between the oral microbiome and neurodevelopmental disorders remains a compelling hypothesis, still requiring confirmation in large-scale datasets. Leveraging over 7000 whole-genome sequenced salivary samples from 2025 US families w
Externí odkaz:
https://doaj.org/article/edc3cac5e25745e7a1d9552f2f277166
Using deep learning to quantify neuronal activation from single-cell and spatial transcriptomic data
Autor:
Ethan Bahl, Snehajyoti Chatterjee, Utsav Mukherjee, Muhammad Elsadany, Yann Vanrobaeys, Li-Chun Lin, Miriam McDonough, Jon Resch, K. Peter Giese, Ted Abel, Jacob J. Michaelson
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Neuronal activity-dependent transcription directs molecular processes that regulate synaptic plasticity, brain circuit development, behavioral adaptation, and long-term memory. Single cell RNA-sequencing technologies (scRNAseq) are rapidly d
Externí odkaz:
https://doaj.org/article/e96049e0c3cb455aa573709afabc010f
Autor:
Yann Vanrobaeys, Utsav Mukherjee, Lucy Langmack, Stacy E. Beyer, Ethan Bahl, Li-Chun Lin, Jacob J. Michaelson, Ted Abel, Snehajyoti Chatterjee
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Memory consolidation involves discrete patterns of transcriptional events in the hippocampus. Despite the emergence of single-cell transcriptomic profiling techniques, mapping the transcriptomic signature across subregions of the hippocampus
Externí odkaz:
https://doaj.org/article/c9c6d21d36984b31bdde6a3055774e4b
Autor:
Taylor R. Thomas, Ashton J. Tener, Amy M. Pearlman, Katherine L. Imborek, Ji Seung Yang, John F. Strang, Jacob J. Michaelson
Publikováno v:
Biological Psychiatry Global Open Science, Vol 4, Iss 2, Pp 100291- (2024)
Background: Gender-diverse individuals are at increased risk for mental health problems, but it is unclear whether this is due to shared environmental or genetic factors. Methods: In two SPARK samples, we tested for associations of 16 polygenic score
Externí odkaz:
https://doaj.org/article/43ea6cc5ea634e64887f4ffe0698ae51
Autor:
Olivia J. Veatch, Diego R. Mazzotti, Robert T. Schultz, Ted Abel, Jacob J. Michaelson, Edward S. Brodkin, Birkan Tunc, Susan G. Assouline, Thomas Nickl-Jockschat, Beth A. Malow, James S. Sutcliffe, Allan I. Pack
Publikováno v:
Journal of Neurodevelopmental Disorders, Vol 14, Iss 1, Pp 1-14 (2022)
Abstract Background Numerous genes are implicated in autism spectrum disorder (ASD). ASD encompasses a wide-range and severity of symptoms and co-occurring conditions; however, the details of how genetic variation contributes to phenotypic difference
Externí odkaz:
https://doaj.org/article/df51aee06324407f89729f2c02cf66d0
Autor:
Taylor R. Thomas, Tanner Koomar, Lucas G. Casten, Ashton J. Tener, Ethan Bahl, Jacob J. Michaelson
Publikováno v:
Translational Psychiatry, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract The complexity of autism’s phenotypic spectra is well-known, yet most genetic research uses case-control status as the target trait. It is undetermined if autistic symptom domain severity underlying this heterogeneity is heritable and plei
Externí odkaz:
https://doaj.org/article/1bf2f73991d549c5809388054d778ba1
Autor:
Marie E. Gaine, Ethan Bahl, Snehajyoti Chatterjee, Jacob J. Michaelson, Ted Abel, Lisa C. Lyons
Publikováno v:
Molecular Brain, Vol 14, Iss 1, Pp 1-17 (2021)
Abstract Widespread sleep deprivation is a continuing public health problem in the United States and worldwide affecting adolescents and adults. Acute sleep deprivation results in decrements in spatial memory and cognitive impairments. The hippocampu
Externí odkaz:
https://doaj.org/article/bb15e6fe706c4cf082e481eb3eaf8668
Autor:
Brooke G. McKenna, Yongchao Huang, Kévin Vervier, Dabney Hofammann, Mary Cafferata, Seima Al-Momani, Florencia Lowenthal, Angela Zhang, Jin-Young Koh, Savantha Thenuwara, Leo Brueggeman, Ethan Bahl, Tanner Koomar, Natalie Pottschmidt, Taylor Kalmus, Lucas Casten, Taylor R. Thomas, Jacob J. Michaelson
Publikováno v:
Molecular Autism, Vol 12, Iss 1, Pp 1-18 (2021)
Abstract Background Neurodevelopmental disorders (NDDs) such as autism spectrum disorder (ASD) display a strong male bias. Androgen exposure is profoundly increased in typical male development, but it also varies within the sexes, and previous work h
Externí odkaz:
https://doaj.org/article/ef178a22689d440e9c21cc683da89eac
Autor:
Tianyun Wang, Kendra Hoekzema, Davide Vecchio, Huidan Wu, Arvis Sulovari, Bradley P. Coe, Madelyn A. Gillentine, Amy B. Wilfert, Luis A. Perez-Jurado, Malin Kvarnung, Yoeri Sleyp, Rachel K. Earl, Jill A. Rosenfeld, Madeleine R. Geisheker, Lin Han, Bing Du, Chris Barnett, Elizabeth Thompson, Marie Shaw, Renee Carroll, Kathryn Friend, Rachael Catford, Elizabeth E. Palmer, Xiaobing Zou, Jianjun Ou, Honghui Li, Hui Guo, Jennifer Gerdts, Emanuela Avola, Giuseppe Calabrese, Maurizio Elia, Donatella Greco, Anna Lindstrand, Ann Nordgren, Britt-Marie Anderlid, Geert Vandeweyer, Anke Van Dijck, Nathalie Van der Aa, Brooke McKenna, Miroslava Hancarova, Sarka Bendova, Marketa Havlovicova, Giovanni Malerba, Bernardo Dalla Bernardina, Pierandrea Muglia, Arie van Haeringen, Mariette J. V. Hoffer, Barbara Franke, Gerarda Cappuccio, Martin Delatycki, Paul J. Lockhart, Melanie A. Manning, Pengfei Liu, Ingrid E. Scheffer, Nicola Brunetti-Pierri, Nanda Rommelse, David G. Amaral, Gijs W. E. Santen, Elisabetta Trabetti, Zdeněk Sedláček, Jacob J. Michaelson, Karen Pierce, Eric Courchesne, R. Frank Kooy, The SPARK Consortium, Magnus Nordenskjöld, Corrado Romano, Hilde Peeters, Raphael A. Bernier, Jozef Gecz, Kun Xia, Evan E. Eichler
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
For many neurodevelopmental disorder (NDD) risk genes, the significance for mutational burden is unestablished. Here, the authors sequence 125 candidate NDD genes in over 16,000 NDD cases; case-control mutational burden analysis identifies 48 genes w
Externí odkaz:
https://doaj.org/article/e984b4b7e89d4200874d3fcd3c269adc
Autor:
Snehajyoti Chatterjee, Christopher C. Angelakos, Ethan Bahl, Joshua D. Hawk, Marie E. Gaine, Shane G. Poplawski, Anne Schneider-Anthony, Manish Yadav, Giulia S. Porcari, Jean-Christophe Cassel, K. Peter Giese, Jacob J. Michaelson, Lisa C. Lyons, Anne-Laurence Boutillier, Ted Abel
Publikováno v:
BMC Biology, Vol 18, Iss 1, Pp 1-23 (2020)
Abstract Background CREB-dependent transcription necessary for long-term memory is driven by interactions with CREB-binding protein (CBP), a multi-domain protein that binds numerous transcription factors potentially affecting expression of thousands
Externí odkaz:
https://doaj.org/article/e6b6bfcdee344950a2153505d055cf6b