Longitudinal transcriptomic analysis of mouse sciatic nerve reveals pathways associated with age‐related muscle pathology

Autor: Nicole Comfort, Meethila Gade, Madeleine Strait, Samantha J. Merwin, Daphne Antoniou, Chiara Parodi, Lina Marcinczyk, Lea Jean‐Francois, Tessa R. Bloomquist, Anna Memou, Hardy J. Rideout, Stefania Corti, Shingo Kariya, Diane B. Re

Publikováno v: Journal of Cachexia, Sarcopenia and Muscle, Vol 14, Iss 3, Pp 1322-1336 (2023)

Abstract Background Sarcopenia, the age‐associated decline in skeletal muscle mass and strength, has long been considered a disease of muscle only, but accumulating evidence suggests that sarcopenia could originate from the neural components contro

Externí odkaz: https://doaj.org/article/971c856039ca453e86c53bf33c9ab51e

Global analysis of prokaryotic tRNA-derived cyclodipeptide biosynthesis

Autor: Michael A. Skinnider, Chad W. Johnston, Nishanth J. Merwin, Chris A. Dejong, Nathan A. Magarvey

Publikováno v: BMC Genomics, Vol 19, Iss 1, Pp 1-11 (2018)

Abstract Background Among naturally occurring small molecules, tRNA-derived cyclodipeptides are a class that have attracted attention for their diverse and desirable biological activities. However, no tools are available to link cyclodipeptide syntha

Externí odkaz: https://doaj.org/article/4161aa238ce542d18449758c8ca3706a

Limitations and Challenges in Modeling Diseases Involving Spinal Motor Neuron Degeneration in Vitro

Autor: Monica Bucchia, Samantha J. Merwin, Diane B. Re, Shingo Kariya

Publikováno v: Frontiers in Cellular Neuroscience, Vol 12 (2018)

Pathogenic conditions involving degeneration of spinal motor neurons (MNs), such as amyotrophic lateral sclerosis, sarcopenia, and spinal cord injury, mostly occur in individuals whose spinal MNs are fully mature. There is currently no effective trea

Externí odkaz: https://doaj.org/article/448ba11ae303488da93df09b7f774a76

Transcriptomic analysis of aging mouse sciatic nerve reveals early pathways leading to sarcopenia

Autor: Nicole Comfort, Meethila Gade, Madeleine Strait, Samantha J. Merwin, Daphne Antoniou, Anna Memou, Hardy J. Rideout, Stefania Corti, Shingo Kariya, Diane B. Re

BackgroundSarcopenia, the age-associated decline in skeletal muscle mass and strength, has long been considered a disease of muscle only, but accumulating evidence suggests that sarcopenia could originate from the neural components controlling muscle

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5dc225c8f92d9569560431276fe7540d
https://doi.org/10.1101/2022.02.01.478571

Austenite Reconstruction Elucidates Prior Grain Size Dependence of Toughness in a Low Alloy Steel

Autor: Vahid Tari, Lionel Germain, Anthony D. Rollett, Chasen Ranger, Matthew J. Merwin, Susan Farjami

Publikováno v: Metallurgical and Materials Transactions A
Metallurgical and Materials Transactions A, Springer Verlag/ASM International, 2018, 49 (10), pp.4521-4535. ⟨10.1007/s11661-018-4825-7⟩

Texture and grain size distribution of the austenite phase at high temperature have distinct effects on the subsequent transformed microstructure and mechanical properties of steel alloys at room temperature. Measurement of austenite at high temperat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b0ace58ba767cffd06abe7ba800c6e7
https://doi.org/10.1007/s11661-018-4825-7