Zobrazeno 1 - 10
of 1 865
pro vyhledávání: '"J, Merrick"'
Autor:
Holly M. Craven, Guilherme Nettesheim, Pietro Cicuta, Andrew M. Blagborough, Catherine J. Merrick
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 23, Iss , Pp 106-119 (2023)
Plasmodium falciparum is the deadliest causative agent of human malaria. This parasite has historically developed resistance to most drugs, including the current frontline treatments, so new therapeutic targets are needed. Our previous work on guanin
Externí odkaz:
https://doaj.org/article/e9371aa70d4440848aa14e1707bd2b4f
Autor:
Jennifer McDonald, Catherine J Merrick
Publikováno v:
PLoS Pathogens, Vol 18, Iss 6, p e1010595 (2022)
Malaria parasites are unusual, early-diverging protozoans with non-canonical cell cycles. They do not undergo binary fission, but divide primarily by schizogony. This involves the asynchronous production of multiple nuclei within the same cytoplasm,
Externí odkaz:
https://doaj.org/article/098088abf6f4439b946e46c1870ca4a2
Autor:
James Edwards-Smallbone, Anders L. Jensen, Lydia E. Roberts, Francis Isidore G. Totañes, Sarah R. Hart, Catherine J. Merrick
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
In the early-diverging protozoan parasite Plasmodium, few telomere-binding proteins have been identified and several are unique. Plasmodium telomeres, like those of most eukaryotes, contain guanine-rich repeats that can form G-quadruplex structures.
Externí odkaz:
https://doaj.org/article/c123ac3231b7406dbe0fd9b15841d2c2
Autor:
Hunter L. Gage, Catherine J. Merrick
Publikováno v:
BMC Genomics, Vol 21, Iss 1, Pp 1-18 (2020)
Abstract Background The Plasmodium genus of malaria parasites encodes several families of antigen-encoding genes. These genes tend to be hyper-variable, highly recombinogenic and variantly expressed. The best-characterized family is the var genes, ex
Externí odkaz:
https://doaj.org/article/e9c6e4c4d18745dcb8b2114625918663
Publikováno v:
PLoS ONE, Vol 17, Iss 9, p e0270863 (2022)
Plasmodium falciparum, a protozoan parasite and causative agent of human malaria, has one of the most A/T-biased genomes sequenced to date. This may give the genome and the transcriptome unusual structural features. Recent progress in sequencing tech
Externí odkaz:
https://doaj.org/article/9e0fa77109ad49d9b27fdcd2bf109709
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 11 (2021)
Externí odkaz:
https://doaj.org/article/881b2c6b82614a94be1b9f0aa447ca63
Autor:
Catherine J. Merrick
Publikováno v:
Trends in Parasitology. 39:12-16
Epigenetic modifications play important roles in the biology of malaria parasites. The new epigenetic mark histone lactylation, discovered only recently in humans, is also present in malaria parasites. It may have important functions as a key player
Autor:
Maria Vittoria Mazzamuto, Melissa J. Merrick, Francesco Bisi, John L. Koprowski, Lucas Wauters, Adriano Martinoli
Publikováno v:
Frontiers in Ecology and Evolution, Vol 8 (2020)
Intraspecific variation in home range size has important implications for the distribution of animals across landscapes and the spatial structuring of population, community, and ecosystem processes. Among species of similar trophic guild and body mas
Externí odkaz:
https://doaj.org/article/b34ed98a4984494e91155f9a65a772d2
Publikováno v:
Parasites & Vectors, Vol 11, Iss 1, Pp 1-13 (2018)
Abstract It is over 100 years since the life-cycle of the malaria parasite Plasmodium was discovered, yet its intricacies remain incompletely understood - a knowledge gap that may prove crucial for our efforts to control the disease. Phenotypic scree
Externí odkaz:
https://doaj.org/article/698ed6d1f7e441c893c5ae9894fc2faa
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract The mechanics of DNA replication and cell cycling are well-characterized in model organisms, but less is known about these basic aspects of cell biology in early-diverging Apicomplexan parasites, which do not divide by canonical binary fissi
Externí odkaz:
https://doaj.org/article/23ef27017c93437bb385de1aeb7f53c9