Zobrazeno 1 - 10
of 1 831
pro vyhledávání: '"J, Mead"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract Amyotrophic lateral sclerosis (ALS) is characterized by degeneration of motor neurons in the central nervous system (CNS). Mutations in the metalloenzyme SOD1 are associated with inherited forms of ALS and cause a toxic gain of function thou
Externí odkaz:
https://doaj.org/article/43dd0b8021d242968a9526c2e1593cad
Autor:
Stephen T. Oh, Srdan Verstovsek, Vikas Gupta, Uwe Platzbecker, Timothy Devos, Jean‐Jacques Kiladjian, Donal P. McLornan, Andrew Perkins, Maria Laura Fox, Mary Frances McMullin, Adam J. Mead, Miklos Egyed, Jiri Mayer, Tomasz Sacha, Jun Kawashima, Mei Huang, Bryan Strouse, Ruben Mesa
Publikováno v:
eJHaem, Vol 5, Iss 1, Pp 105-116 (2024)
Abstract Bone marrow fibrosis (BMF) is a pathological feature of myelofibrosis, with higher grades associated with poor prognosis. Limited data exist on the association between outcomes and BMF changes. We present BMF data from Janus kinase (JAK) inh
Externí odkaz:
https://doaj.org/article/e5b1d836647843f987f4afa02212f957
Autor:
Zijian Fang, Giuditta Corbizi Fattori, Thomas McKerrell, Rebecca H. Boucher, Aimee Jackson, Rachel S. Fletcher, Dorian Forte, Jose-Ezequiel Martin, Sonia Fox, James Roberts, Rachel Glover, Erica Harris, Hannah R. Bridges, Luigi Grassi, Alba Rodriguez-Meira, Adam J. Mead, Steven Knapper, Joanne Ewing, Nauman M. Butt, Manish Jain, Sebastian Francis, Fiona J. Clark, Jason Coppell, Mary F. McMullin, Frances Wadelin, Srinivasan Narayanan, Dragana Milojkovic, Mark W. Drummond, Mallika Sekhar, Hesham ElDaly, Judy Hirst, Maike Paramor, E. Joanna Baxter, Anna L. Godfrey, Claire N. Harrison, Simón Méndez-Ferrer
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
Abstract Current therapies for myeloproliferative neoplasms (MPNs) improve symptoms but have limited effect on tumor size. In preclinical studies, tamoxifen restored normal apoptosis in mutated hematopoietic stem/progenitor cells (HSPCs). TAMARIN Pha
Externí odkaz:
https://doaj.org/article/16a1a95232b2462f94a84a299c0e1020
Autor:
Peter J. Richardson, Daniel P. Smith, Alex de Giorgio, Xenia Snetkov, Joshua Almond-Thynne, Sara Cronin, Richard J. Mead, Christopher J. McDermott, Pamela J. Shaw
Publikováno v:
Translational Neurodegeneration, Vol 12, Iss 1, Pp 1-17 (2023)
Abstract Amyotrophic lateral sclerosis (ALS) is a poorly treated multifactorial neurodegenerative disease associated with multiple cell types and subcellular organelles. As with other multifactorial diseases, it is likely that drugs will need to targ
Externí odkaz:
https://doaj.org/article/f1de506708b2457081b6e57e8800b184
Autor:
Tiago C. Luis, Nikolaos Barkas, Joana Carrelha, Alice Giustacchini, Stefania Mazzi, Ruggiero Norfo, Bishan Wu, Affaf Aliouat, Jose A. Guerrero, Alba Rodriguez-Meira, Tiphaine Bouriez-Jones, Iain C. Macaulay, Maria Jasztal, Guangheng Zhu, Heyu Ni, Matthew J. Robson, Randy D. Blakely, Adam J. Mead, Claus Nerlov, Cedric Ghevaert, Sten Eirik W. Jacobsen
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Hematopoietic stem cells (HSCs) residing in specialized niches in the bone marrow are responsible for the balanced output of multiple short-lived blood cell lineages in steady-state and in response to different challenges. However, feedback
Externí odkaz:
https://doaj.org/article/45c592524cf44d3ebb3a8722a44142e6
Autor:
V. Nandan, R. Willatt, R. Mallett, J. Stroeve, T. Geldsetzer, R. Scharien, R. Tonboe, J. Yackel, J. Landy, D. Clemens-Sewall, A. Jutila, D. N. Wagner, D. Krampe, M. Huntemann, M. Mahmud, D. Jensen, T. Newman, S. Hendricks, G. Spreen, A. Macfarlane, M. Schneebeli, J. Mead, R. Ricker, M. Gallagher, C. Duguay, I. Raphael, C. Polashenski, M. Tsamados, I. Matero, M. Hoppmann
Publikováno v:
The Cryosphere, Vol 17, Pp 2211-2229 (2023)
Wind-driven redistribution of snow on sea ice alters its topography and microstructure, yet the impact of these processes on radar signatures is poorly understood. Here, we examine the effects of snow redistribution over Arctic sea ice on radar wavef
Externí odkaz:
https://doaj.org/article/0d534129bf89421db91797da9a4e31b1
Autor:
Ruben A. Mesa, Stacie Hudgens, Lysbeth Floden, Claire N. Harrison, Jeanne Palmer, Vikas Gupta, Donal P. McLornan, Mary F. McMullin, Jean‐Jaques Kiladjian, Lynda Foltz, Uwe Platzbecker, M. Laura Fox, Adam J. Mead, David M. Ross, Stephen T. Oh, Andrew Perkins, Michael F. Leahy, Samineh Deheshi, Rafe Donahue, Barbara J. Klencke, Srdan Verstovsek
Publikováno v:
Cancer Medicine, Vol 12, Iss 9, Pp 10612-10624 (2023)
Abstract Background Myelofibrosis (MF)‐associated constitutional symptoms can severely impact health‐related quality of life. Clinical trials in MF traditionally measure symptom response to treatment as a landmark endpoint of total symptom score
Externí odkaz:
https://doaj.org/article/e6eb999637b34b008d60fd675f19d445
Autor:
Griffin J. Mead, Daniel I. Herman, Fabrizio R. Giorgetta, Nathan A. Malarich, Esther Baumann, Brian R. Washburn, Nathan R. Newbury, Ian Coddington, Kevin C. Cossel
Publikováno v:
Geophysical Research Letters, Vol 51, Iss 2, Pp n/a-n/a (2024)
Abstract Quantifying sector‐resolved methane fluxes in complex emissions environments is challenging yet necessary to improve emissions inventories and guide policy. Here, we separate energy and agriculture sector emissions using a dynamic linear m
Externí odkaz:
https://doaj.org/article/f1fc61fe866d4865835b69636ed836e4
Publikováno v:
The Open Journal of Astrophysics, Vol 6 (2023)
We present a pedagogical review of the halo model, a flexible framework that can describe the distribution of matter and its tracers on non-linear scales for both conventional and exotic cosmological models. We start with the premise that the complex
Externí odkaz:
https://doaj.org/article/41b95824c3244c5ea23d519d0c3840de
Autor:
Ruben A. Mesa, Claire Harrison, Jeanne M. Palmer, Vikas Gupta, Donal P. McLornan, Mary Frances McMullin, Jean-Jacques Kiladjian, Lynda Foltz, Uwe Platzbecker, Maria Laura Fox, Adam J. Mead, David M. Ross, Stephen T. Oh, Andrew Charles Perkins, Michael F. Leahy, Jun Kawashima, Sunhee Ro, Rafe Donahue, Boris Gorsh, Samineh Deheshi, Srdan Verstovsek
Publikováno v:
HemaSphere, Vol 7, Iss 11, p e966 (2023)
Myelofibrosis (MF) is a chronic myeloproliferative neoplasm that typically manifests with debilitating symptoms that progressively worsen, negatively impacting patients’ quality of life. Fatigue is a multifactorial and burdensome MF-related symptom
Externí odkaz:
https://doaj.org/article/f9632edb1b7c4fa09e09d3f5fe8a8134