Zobrazeno 1 - 10 of 213 pro vyhledávání: '"J, Markussen"'
1
Akademický článek
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2
Human Monocomponent Insulin
Autor: Lars Thim, Klavs Holger Jorgensen, Erik Sorensen, J. Markussen, U. Damgaard
Publikováno v: Acta Medica Scandinavica. 213:99-105
The primary structure of different insulins is reviewed and the properties, identification tests, purity, potency and immunogenicity of human insulin are summerized. Novo Research Institute has developed a method, simply using an enzymatic conversion
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::77ba2b66f247e4f03a1220073179460e
https://doi.org/10.1111/j.0954-6820.1983.tb08555.x
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5
Role of B13 Glu in insulin assembly
Autor: Eleanor J. Dodson, J. Markussen, B. Xiao, Graham A. Bentley, A. Wollmer, Anthony J. Wilkinson, J. Brange, Zygmunt S. Derewenda, Guy Dodson
Publikováno v: Journal of Molecular Biology. 228:1163-1176
The assembly of the insulin hexamer brings the six B13 glutamate side-chains at the centre into close proximity. Their mutual repulsion is unfavourable and zinc co-ordination to B10 histidine is necessary to stabilize the well known zinc-containing h
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8bd53de57b34510350e9e3824ab8d025
https://doi.org/10.1016/0022-2836(92)90323-c
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6
Immobilized insulin for high capacity affinity chromatography of insulin receptors
Autor: J Markussen, Lauge Schäffer, Finn C. Wiberg, J. Halstrom
Publikováno v: Journal of Biological Chemistry. 266:18814-18818
Insulin receptors can be purified by affinity chromatography on immobilized insulin, but published methods all suffer from a rather low capacity of the affinity columns. By using insulin that has been protected in positions A1 and B29, we have been a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e815a71d1a0fe74108693549639ed046
https://doi.org/10.1016/s0021-9258(18)55136-x
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8
Akademický článek
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9
Role of B13 Glu in insulin assembly. The hexamer structure of recombinant mutant (B13 Glu--Gln) insulin
Autor: G A, Bentley, J, Brange, Z, Derewenda, E J, Dodson, G G, Dodson, J, Markussen, A J, Wilkinson, A, Wollmer, B, Xiao
Publikováno v: Journal of molecular biology. 228(4)
The assembly of the insulin hexamer brings the six B13 glutamate side-chains at the centre into close proximity. Their mutual repulsion is unfavourable and zinc co-ordination to B10 histidine is necessary to stabilize the well known zinc-containing h
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f7b239cc4eff4907d1542959c3d98a8a
https://pubmed.ncbi.nlm.nih.gov/1361949
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10
Application of the euglycaemic clamp technique to bioassay of insulin analogues
Autor: L. Langkjaer, U. Ribel, A. Vølund, P.L. Dam, J. Dolben, J. Markussen, D. R. Owens
Publikováno v: Biologicals : journal of the International Association of Biological Standardization. 20(2)
The euglycaemic clamp method may offer a precise and clinically valid approach to assess the in vivo potency of new insulin analogues or derivatives relative to a human insulin standard. The proposed protocol was designed to overcome problems due to
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9382bf7bcbee5b021830fdde71e74bfd
https://pubmed.ncbi.nlm.nih.gov/1389109
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