Zobrazeno 1 - 10
of 118
pro vyhledávání: '"J, Majoros"'
Autor:
Istvan J. Majoros, Paul E. Makidon, Jingga Morry, Rong Qi, Sascha N. Goonewardena, Hubert Marotte, Alisa E. Koch, Phil Campbell, Ingrid L. Bergin, James R. Baker, Michael A. Beer, Alina Kotlyar, Zhengyi Cao, Thommey P. Thomas, Shuai Zhang, Asish C. Misra
Publikováno v:
Journal of Biomedical Nanotechnology. 11:1431-1441
Generation 5 (G5) poly(amidoamide) (PAMAM) dendrimers are synthetic polymers that have been broadly applied as drug delivery carriers. Methotrexate (MTX), an anti-folate metabolite, has been successfully used as an anti-inflammatory drug to treat rhe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e66e44566cb89c0d9fbe28480e7d358
https://doi.org/10.1166/jbn.2015.2077
https://doi.org/10.1166/jbn.2015.2077
Autor:
Christopher V. Kelly, Yueyang Zhong, Douglas G. Mullen, Mark M. Banaszak Holl, Bradford G. Orr, Daniel Q. McNerny, Suyang Qin, Istvan J. Majoros, Alina Kotlyar, Stassi DiMaggio, James R. Baker, Thommey P. Thomas, Ankur Desai, Xue-Min Cheng
Publikováno v:
Bioconjugate Chemistry. 22:679-689
A modular dendrimer-based drug delivery platform was designed to improve upon existing limitations in single dendrimer systems. Using this modular strategy, a biologically active platform containing receptor mediated targeting and fluorescence imagin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2b021dc3756a8ec64da7d4b1136f9f2
https://doi.org/10.1021/bc100360v
https://doi.org/10.1021/bc100360v
Autor:
Thommey P. Thomas, Alina Kotlyar, Istvan J. Majoros, Douglas G. Mullen, James R. Baker, Mark M. Banaszak Holl
Publikováno v:
Biomacromolecules. 10:3207-3214
Poly(amidoamine) (PAMAM) dendrimers carrying different amounts of surface amino groups were synthesized and tested for their effects on cellular cytotoxicity, lysosomal pH, and mitochondria-dependent apoptosis. In KB cells, the PAMAM dendrimers were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1568362c303cb86162f50616021063e8
https://doi.org/10.1021/bm900683r
https://doi.org/10.1021/bm900683r
Autor:
Anna U. Bielinska, Bradford G. Orr, Luz P. Blanco, Douglas G. Mullen, James R. Baker, Rahul Rattan, Mark M. Banaszak Holl, Istvan J. Majoros, Seungpyo Hong, Jennifer L. Peters, Xiangyang Shi
Publikováno v:
Bioconjugate Chemistry. 20:1503-1513
Generation 7 (G7) poly(amidoamine) (PAMAM) dendrimers with amine, acetamide, and carboxylate end groups were prepared to investigate polymer/cell membrane interactions in vitro. G7 PAMAM dendrimers were used in this study because higher-generation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c608445a0d75df4adfacca7728a06d46
https://doi.org/10.1021/bc900029k
https://doi.org/10.1021/bc900029k
Publikováno v:
Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology. 1:502-510
This paper provides a synopsis of the advancements made in advancing a dendrimer-based nanomedicine towards human clinical trials by the Michigan Nanotechnology Institute for Medicine and Biological Sciences. A brief description of the synthesis and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::81384476d96a7d5421d1fc44383aed41
https://doi.org/10.1002/wnan.37
https://doi.org/10.1002/wnan.37
Publikováno v:
Journal of Computational and Theoretical Nanoscience. 6:54-60
Molecular dynamics simulations of nano-therapeutics as a final product and of all intermediates in the process of generating a multi-functional nano-therapeutic based on a poly(amidoamine) (PAMAM) dendrimer were performed along with chemical analyses
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63dc2fd62fe9d442cc3c386faf6d2e31
https://doi.org/10.1166/jctn.2009.1006
https://doi.org/10.1166/jctn.2009.1006
Publikováno v:
Macromolecules. 41:8372-8379
Recently developed multifunctional cancer therapeutic nano-device production is based on poly(amidoamine) PAMAM generation 5 (G5) dendrimer as a carrier 1-5. Scale up synthesis of this nano-device is limited because of long reaction sequence (12 reac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54f37b26948aee0fc9648b6815fa8880
https://doi.org/10.1021/ma801843a
https://doi.org/10.1021/ma801843a
Publikováno v:
Journal of Computational and Theoretical Nanoscience. 4:1179-1187
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ce4c24ab4068f18229017ff959555d79
https://doi.org/10.1166/jctn.2007.2396
https://doi.org/10.1166/jctn.2007.2396
Publikováno v:
Biomacromolecules. 8:13-18
Our previous studies have demonstrated the applicability of poly(amidoamine) (PAMAM) dendrimers as a platform for the targeted delivery of chemotherapeutic drugs both in vitro and in vivo. To monitor the rate and extent of cell-killing caused by the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::103546ccc0c15a82a1764c6bfaa83a9f
https://doi.org/10.1021/bm060815l
https://doi.org/10.1021/bm060815l
Autor:
Karen J. Roelofs, James C. Stanley, Brenda S. Cho, James R. Baker, Gilbert R. Upchurch, Istvan J. Majoros, Peter K. Henke
Publikováno v:
Annals of the New York Academy of Sciences. 1085:294-305
In this study, the distribution of labeled dendrimers in native and aneurysmal rat aortic tissue was examined. Adult male rats underwent infrarenal aorta perfusion with generation 5 (G5) acetylated Alexa Fluor 488-conjugated dendrimers for varying le
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf08710d96689a8c966c7c6ac09fe0b8
https://doi.org/10.1196/annals.1383.004
https://doi.org/10.1196/annals.1383.004