A Biomimetic Approach to Premyrsinane-Type Diterpenoids: Exploring Microbial Transformation to Enhance Their Chemical Diversity

Autor: Felipe Escobar-Montaño, Antonio J. Macías-Sánchez, José M. Botubol-Ares, Rosa Durán-Patrón, Rosario Hernández-Galán

Publikováno v: Plants, Vol 13, Iss 6, p 842 (2024)

Premyrsinane-type diterpenoids have been considered to originate from the cyclization of a suitable 5,6- or 6,17-epoxylathyrane precursor. Their biological activities have not been sufficiently explored to date, so the development of synthetic or mic

Externí odkaz: https://doaj.org/article/51343340fa494b35b077b9f9ca3b48c9

Synthesis, Fungitoxic Activity against Botrytis cinerea and Phytotoxicity of Alkoxyclovanols and Alkoxyisocaryolanols

Autor: Adriana de Almeida Pinto Bracarense, Jociani Ascari, Giovanni Gontijo de Souza, Thays Silva Oliveira, Antonio Ruano-González, Ana A. Pinto, Maria Amélia Diamantino Boaventura, Jacqueline Aparecida Takahashi, Isidro G. Collado, Rosa Durán-Patrón, Antonio J. Macías-Sánchez

Publikováno v: Journal of Fungi, Vol 7, Iss 12, p 1079 (2021)

Clovane and isocaryolane derivatives have been proven to show several levels of activity against the phytopathogenic fungus Botrytis cinerea. Both classes of sesquiterpenes are reminiscent of biosynthetic intermediates of botrydial, a virulence facto

Externí odkaz: https://doaj.org/article/b5963c10522e4054983e92ac2521d7fd

Correction to 'Phorbol Diesters and 12-Deoxy-16-hydroxyphorbol 13,16-Diesters Induce TGFα Release and Adult Mouse Neurogenesis'

Autor: Abdellah Ezzanad, Ricardo Gómez-Oliva, Felipe Escobar-Montaño, Mónica Díez-Salguero, Noelia Geribaldi-Doldan, Samuel Dominguez-Garcia, José Manuel Botubol-Ares, Carolina de los Reyes, Rosa Durán-Patrón, Pedro Nunez-Abades, Antonio J. Macías-Sánchez, Carmen Castro, Rosario Hernández-Galán

Publikováno v: Journal of Medicinal Chemistry. 65:10707-10708

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c66a4dbee1244cc428f08deaec890a3e
https://doi.org/10.1021/acs.jmedchem.2c01090

Lathyrane, Premyrsinane, and Related Diterpenes from Euphorbia boetica: Effect on in Vitro Neural Progenitor Cell Proliferation

Autor: Antonio J. Macías-Sánchez, Maribel Murillo-Carretero, Carmen Castro, Noelia Geribaldi-Doldán, Eugenia Flores-Giubi, Rosario Hernández-Galán, Rosa Durán-Patrón

Publikováno v: Journal of Natural Products. 82:2517-2528

Lathyrane-type diterpenes previously have been proven to promote proliferation of neural precursor cells (NPCs) by targeting and activating one or more protein kinase C (PKC) isozymes. Aiming to find new drug candidates with a lathyrane skeleton to m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be01a77ec51bd011b7471ea2021cd925
https://doi.org/10.1021/acs.jnatprod.9b00343

Phorbol Diesters and 12-Deoxy-16-hydroxyphorbol 13,16-Diesters Induce TGFα Release and Adult Mouse Neurogenesis

Autor: Abdellah Ezzanad, José Manuel Botubol-Ares, Samuel Domínguez-García, Felipe Escobar-Montaño, Mónica Díez-Salguero, Ricardo Gómez-Oliva, Carmen Castro, Carolina de los Reyes, Pedro Nunez-Abades, Rosa Durán-Patrón, Noelia Geribaldi-Doldán, Antonio J. Macías-Sánchez, Rosario Hernández-Galán

Publikováno v: idUS. Depósito de Investigación de la Universidad de Sevilla
instname
J. Med. Chem. 2021, 64, 6070−6084
RODIN: Repositorio de Objetos de Docencia e Investigación de la Universidad de Cádiz
Universidad de Cádiz
RODIN. Repositorio de Objetos de Docencia e Investigación de la Universidad de Cádiz

A small library of phorbol 12,13-diesters bearing low lipophilicity ester chains was prepared as potential neurogenic agents in the adult brain. They were also used in a targeted UHPLC-HRMS screening of the latex of Euphorbia resinifera. Two new 12-d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::baf1cd4d089b190e3bcc4bd8d2f291c9