Zobrazeno 1 - 10
of 1 170
pro vyhledávání: '"J, Mäkinen"'
Autor:
A. J. Hepburn, C. F. Dow, A. Ojala, J. Mäkinen, E. Ahokangas, J. Hovikoski, J.-P. Palmu, K. Kajuutti
Publikováno v:
The Cryosphere, Vol 18, Pp 4873-4916 (2024)
Unknown basal characteristics limit our ability to simulate the subglacial hydrology of rapidly melting contemporary ice sheets. Sediment-based landforms generated beneath Late Pleistocene ice sheets, together with detailed digital elevation models,
Externí odkaz:
https://doaj.org/article/a93dd1391601433d84bdbd6519a1dc7e
Autor:
Raila Aro, Pasi Ohtonen, Tero Rautio, Juha Saarnio, Elisa Mäkäräinen, Reetta Häivälä, Markus J. Mäkinen, Anne Tuomisto, Ursula Schwab, Sanna Meriläinen
Publikováno v:
BMC Nutrition, Vol 8, Iss 1, Pp 1-11 (2022)
Abstract Background Colon cancer is one of the most common cancers in Finland and worldwide. Cancer-related malnutrition is a well-known risk factor for increased morbidity and mortality after surgery, and it is associated with complications and long
Externí odkaz:
https://doaj.org/article/44f2036728704e769e467ae9305efc74
Autor:
Janne J. Mäkinen, Yeonoh Shin, Eeva Vieras, Pasi Virta, Mikko Metsä-Ketelä, Katsuhiko S. Murakami, Georgiy A. Belogurov
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
RNA and DNA polymerases need to discriminate efficiently against closely related nucleotide triphosphate substrates. Here, the authors show that a conserved Arg residue is the major determinant of selectivity against deoxyribonucleoside substrates by
Externí odkaz:
https://doaj.org/article/1a267789452f415e8760bfc2fe901636
Autor:
Emerik Osterlund, Ari Ristimäki, Soili Kytölä, Teijo Kuopio, Eetu Heervä, Timo Muhonen, Päivi Halonen, Raija Kallio, Leena-Maija Soveri, Jari Sundström, Mauri Keinänen, Annika Ålgars, Raija Ristamäki, Halfdan Sorbye, Per Pfeiffer, Luís Nunes, Tapio Salminen, Annamarja Lamminmäki, Markus J. Mäkinen, Tobias Sjöblom, Helena Isoniemi, Bengt Glimelius, Pia Osterlund
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
BackgroundKRAS mutations, present in over 40% of metastatic colorectal cancer (mCRC), are negative predictive factors for anti-EGFR therapy. Mutations in KRAS-G12C have a cysteine residue for which drugs have been developed. Published data on this sp
Externí odkaz:
https://doaj.org/article/decb120b6a4a470ea68f4e7d8f7c7d6d
Autor:
Saku J. Mäkinen
Publikováno v:
CERN IdeaSquare Journal of Experimental Innovation, Vol 5, Iss 2 (2021)
The papers presented in this issue have multiple implications for Universities wishing to innovate their offering to respond to new and pressing societal challenges; for policymakers that have the responsibility to promote more impactful open science
Externí odkaz:
https://doaj.org/article/2d4ddd5f81db4ca7ae16ac48a482c81d
Autor:
Joonas Iivanainen, Antti J. Mäkinen, Rasmus Zetter, Matti Stenroos, Risto J. Ilmoniemi, Lauri Parkkonen
Publikováno v:
NeuroImage, Vol 245, Iss , Pp 118747- (2021)
In this paper, we analyze spatial sampling of electro- (EEG) and magnetoencephalography (MEG), where the electric or magnetic field is typically sampled on a curved surface such as the scalp. By simulating fields originating from a representative adu
Externí odkaz:
https://doaj.org/article/c76707be7d064028b2f5ef440d8736b5
Platelet count, aspirin use, and characteristics of host inflammatory responses in colorectal cancer
Autor:
Juha P. Väyrynen, Sara A. Väyrynen, Päivi Sirniö, Ilkka Minkkinen, Kai Klintrup, Toni Karhu, Jyrki Mäkelä, Karl-Heinz Herzig, Tuomo J. Karttunen, Anne Tuomisto, Markus J. Mäkinen
Publikováno v:
Journal of Translational Medicine, Vol 17, Iss 1, Pp 1-13 (2019)
Abstract Background Platelets not only contribute to hemostasis but also to the regulation of inflammatory reactions and cancer pathogenesis. We hypothesized that blood platelet count would be associated with systemic inflammation, the densities of t
Externí odkaz:
https://doaj.org/article/cdb7cee9f9f1423098398a7819b66244
Autor:
Peter Hömmen, Antti J. Mäkinen, Alexander Hunold, René Machts, Jens Haueisen, Koos C. J. Zevenhoven, Risto J. Ilmoniemi, Rainer Körber
Publikováno v:
Frontiers in Physics, Vol 8 (2020)
Magnetic fields associated with currents flowing in tissue can be measured non-invasively by means of zero-field-encoded ultra-low-field magnetic resonance imaging (ULF MRI) enabling current-density imaging (CDI) and possibly conductivity mapping of
Externí odkaz:
https://doaj.org/article/f4cb61c9620f4feabd2c87a6ea529ca9
Autor:
Päivi Sirniö, Juha P. Väyrynen, Shivaprakash J. Mutt, Karl-Heinz Herzig, Jaroslaw Walkowiak, Kai Klintrup, Jyrki Mäkelä, Tuomo J. Karttunen, Markus J. Mäkinen, Anne Tuomisto
Publikováno v:
OncoImmunology, Vol 9, Iss 1 (2020)
Systemic inflammation is a stage-independent marker of poor prognosis in colorectal cancer (CRC), activated in a complex, multifactorial process. It has been proposed that one of the main factors driving systemic inflammation may be tumor necrosis. K
Externí odkaz:
https://doaj.org/article/981aba4ffc464dab9d0d7e328a794ded