Zobrazeno 1 - 10
of 2 424
pro vyhledávání: '"J, Lord"'
Autor:
M. T. Herrera-Abreu, J. Guan, U. Khalid, J. Ning, M. R. Costa, J. Chan, Q. Li, J-P. Fortin, W. R. Wong, P. Perampalam, A. Biton, W. Sandoval, J. Vijay, M. Hafner, R. Cutts, G. Wilson, J. Frankum, T. I. Roumeliotis, J. Alexander, O. Hickman, R. Brough, S. Haider, J. Choudhary, C. J. Lord, A. Swain, C. Metcalfe, N. C. Turner
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract CDK4/6 inhibition in combination with endocrine therapy is the standard of care for estrogen receptor (ER+) breast cancer, and although cytostasis is frequently observed, new treatment strategies that enhance efficacy are required. Here, we
Externí odkaz:
https://doaj.org/article/b017bcff889f48aab6b6f9fbfc965a35
Autor:
Arthur Charles-Orszag, Marleen van Wolferen, Samuel J. Lord, Sonja-Verena Albers, R. Dyche Mullins
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-9 (2024)
Abstract Type IV pili are filamentous appendages found in most bacteria and archaea, where they can support functions such as surface adhesion, DNA uptake, aggregation, and motility. In most bacteria, PilT-family ATPases disassemble adhesion pili, ca
Externí odkaz:
https://doaj.org/article/a10d82320d954b06a8f219d7120a8bbd
Autor:
Doah Cho, Sarah J. Lord, Robyn Ward, Maarten IJzerman, Andrew Mitchell, David M. Thomas, Saskia Cheyne, Andrew Martin, Rachael L. Morton, John Simes, Chee Khoon Lee
Publikováno v:
Therapeutic Advances in Medical Oncology, Vol 16 (2024)
Background: Advances in targeted therapy development and tumor sequencing technology are reclassifying cancers into smaller biomarker-defined diseases. Randomized controlled trials (RCTs) are often impractical in rare diseases, leading to calls for s
Externí odkaz:
https://doaj.org/article/01054442bb48485e8ed565d3f77224e0
Autor:
Joseph S. Baxter, Rachel Brough, Dragomir B. Krastev, Feifei Song, Sandhya Sridhar, Aditi Gulati, John Alexander, Theodoros I. Roumeliotis, Zuza Kozik, Jyoti S. Choudhary, Syed Haider, Stephen J. Pettitt, Andrew N. J. Tutt, Christopher J. Lord
Publikováno v:
Molecular Oncology, Vol 18, Iss 2, Pp 369-385 (2024)
The F‐box and WD repeat domain containing 7 (FBXW7) tumour suppressor gene encodes a substrate‐recognition subunit of Skp, cullin, F‐box (SCF)‐containing complexes. The tumour‐suppressive role of FBXW7 is ascribed to its ability to drive ub
Externí odkaz:
https://doaj.org/article/394126b61bef4541813ab49cbc06b55c
Autor:
Christian Müller, Richard Body, Allan S Jaffe, Gerard Devlin, Richard W Troughton, Sarah J Lord, Nicholas Mills, Peter Kavsak, Louise Cullen, Martin Than, Chris Frampton, John W Pickering, Suzanne Pitama, W Frank Peacock, Sally Aldous, Fred S Apple, Laura Joyce, Cameron James Lacey, Arthur M Richards
Publikováno v:
BMJ Open, Vol 14, Iss 6 (2024)
Introduction Clinical assessment in emergency departments (EDs) for possible acute myocardial infarction (AMI) requires at least one cardiac troponin (cTn) blood test. The turn-around time from blood draw to posting results in the clinical portal for
Externí odkaz:
https://doaj.org/article/14250be12aa0419fb2bc5a7b80448321
Publikováno v:
Trials, Vol 24, Iss 1, Pp 1-11 (2023)
Abstract Background Around 10% of school-aged children experience mental health difficulties. Many more are ‘vulnerable’: experiencing emotional and/or behavioural problems reaching clinical levels, and thus at greatest risk of future mental illn
Externí odkaz:
https://doaj.org/article/d7d7ba4cc22441628926755f27b63c2a
Publikováno v:
Molecular Oncology, Vol 16, Iss 21, Pp 3811-3827 (2022)
The DNA damage response (DDR) represents a complex network of proteins which detect and repair DNA damage, thereby maintaining the integrity of the genome and preventing the transmission of mutations and rearranged chromosomes to daughter cells. Faul
Externí odkaz:
https://doaj.org/article/e87726dbc3f540c286c4a2cae2a824aa
Autor:
Anabel Zelceski, Paola Francica, Lea Lingg, Merve Mutlu, Colin Stok, Martin Liptay, John Alexander, Joseph S. Baxter, Rachel Brough, Aditi Gulati, Syed Haider, Maya Raghunandan, Feifei Song, Sandhya Sridhar, Josep V. Forment, Mark J. O’Connor, Barry R. Davies, Marcel A.T.M. van Vugt, Dragomir B. Krastev, Stephen J. Pettitt, Andrew N.J. Tutt, Sven Rottenberg, Christopher J. Lord
Publikováno v:
Cell Reports, Vol 42, Iss 5, Pp 112484- (2023)
Summary: The PSMC3IP-MND1 heterodimer promotes meiotic D loop formation before DNA strand exchange. In genome-scale CRISPR-Cas9 mutagenesis and interference screens in mitotic cells, depletion of PSMC3IP or MND1 causes sensitivity to poly (ADP-Ribose
Externí odkaz:
https://doaj.org/article/9820d80912b4460eb12878b12cea41b1
Autor:
Christopher G Maher, Gustavo C Machado, Joshua Zadro, Danielle Coombs, Alla Melman, Harrison J Lord
Publikováno v:
BMJ Open, Vol 13, Iss 4 (2023)
Objectives To determine the proportion of low back pain presentations that are admitted to hospital from the emergency department (ED), the proportion of hospital admissions due to a primary diagnosis of low back pain and the mean hospital length of
Externí odkaz:
https://doaj.org/article/338ba3030a8542529b15640145416d99
Autor:
Divya K. Madhusudhan, Sharon A. Watts, Daniel J. Lord, Fiona Ding, David C. Lawrence, Austin Sheldon, James Leonard, Dena M. Bravata
Publikováno v:
Telemedicine Reports, Vol 2, Iss 1, Pp 247-257 (2021)
Background: Since the explosion of telemedicine resulting from the SARS-CoV2 pandemic, employers have been particularly interested in virtual primary care as a novel means of expanding primary care services. The purpose of this study is to describe a
Externí odkaz:
https://doaj.org/article/109af8f5dbe14611b5ef7bcbdcb1e82f