Zobrazeno 1 - 10
of 128
pro vyhledávání: '"J, Litherland"'
Autor:
Sabha Asghar, Gary J. Litherland, John J. Cole, Iain B. McInnes, R. M. D. Meek, John C. Lockhart, Carl S. Goodyear, Anne Crilly
Publikováno v:
Arthritis Research & Therapy, Vol 26, Iss 1, Pp 1-14 (2024)
Abstract Background Small extracellular vesicles (sEV) derived from synovial fibroblasts (SF) represent a novel molecular mechanism regulating cartilage erosion in osteoarthritis (OA). However, a comprehensive evaluation using disease relevant cells
Externí odkaz:
https://doaj.org/article/3b5cf59e34534e7c8772f11be34ab22f
Autor:
C. Huesa, L. Dunning, K. MacDougall, M. Fegen, A. Ortiz, K. McCulloch, S. McGrath, G. J. Litherland, A. Crilly, R. J. Van ‘T Hof, W. R. Ferrell, C. S. Goodyear, J. C. Lockhart
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Exercise is recommended as a non-pharmacological therapy for osteoarthritis (OA). Various exercise regimes, with differing intensities and duration, have been used in a range of OA rodent models. These studies show gentle or moderate exercise reduces
Externí odkaz:
https://doaj.org/article/b2684c9205a84ffe9ae3356f5bf96f44
Autor:
Bryn Short, Christopher Delaney, Emily McKloud, Jason L. Brown, Ryan Kean, Gary J. Litherland, Craig Williams, S. Lorraine Martin, William G. MacKay, Gordon Ramage
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 11 (2021)
Candida albicans is an opportunistic pathogen found throughout multiple body sites and is frequently co-isolated from infections of the respiratory tract and oral cavity with Staphylococcus aureus. Herein we present the first report of the effects th
Externí odkaz:
https://doaj.org/article/79c41a5b8cea492a9446c40ef919642d
Autor:
Gillian A. Kelly-Robinson, James A. Reihill, Fionnuala T. Lundy, Lorcan P. McGarvey, John C. Lockhart, Gary J. Litherland, Keith D. Thornbury, S. Lorraine Martin
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 12, p 6351 (2021)
Chronic obstructive pulmonary disease (COPD) is a debilitating heterogeneous disease characterised by unregulated proteolytic destruction of lung tissue mediated via a protease-antiprotease imbalance. In COPD, the relationship between the neutrophil
Externí odkaz:
https://doaj.org/article/21c93c68852c4eeca0215a3ab6951ea2
Autor:
Emma L. Carroll, Mariarca Bailo, James A. Reihill, Anne Crilly, John C. Lockhart, Gary J. Litherland, Fionnuala T. Lundy, Lorcan P. McGarvey, Mark A. Hollywood, S. Lorraine Martin
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 11, p 5817 (2021)
Trypsin-like proteases (TLPs) belong to a family of serine enzymes with primary substrate specificities for the basic residues, lysine and arginine, in the P1 position. Whilst initially perceived as soluble enzymes that are extracellularly secreted,
Externí odkaz:
https://doaj.org/article/16bc085f972941f9af4ac4ef3a584d65
Autor:
Jonathan Baker, Adrian M D Falconer, David J Wilkinson, G Nicholas Europe-Finner, Gary J Litherland, Andrew D Rowan
Publikováno v:
PLoS ONE, Vol 13, Iss 4, p e0195864 (2018)
Many catabolic stimuli, including interleukin-1 (IL-1) in combination with oncostatin M (OSM), promote cartilage breakdown via the induction of collagen-degrading collagenases such as matrix metalloproteinase 1 (MMP1) and MMP13 in human articular cho
Externí odkaz:
https://doaj.org/article/dd7b44edb653406f81df8918086f1e74
Autor:
Christopher D Macdonald, Adrian M D Falconer, Chun Ming Chan, David J Wilkinson, Andrew Skelton, Louise Reynard, Gary J Litherland, G Nicholas Europe-Finner, Andrew D Rowan
Publikováno v:
PLoS ONE, Vol 13, Iss 11, p e0207240 (2018)
Irreversible cartilage collagen breakdown by the collagenolytic matrix metalloproteinases (MMPs)-1 and MMP-13 represents a key event in pathologies associated with tissue destruction such as arthritis. Inflammation is closely associated with such pat
Externí odkaz:
https://doaj.org/article/6794cdb9cbfc432f992af1601bd2260d
Autor:
Rob van 't Hof, Kendall McCulloch, Kayleigh MacDougal, Carl S. Goodyear, William R. Ferrell, Sarah McGrath, Lynette Dunning, John C. Lockhart, Ana C. Ortiz, Margaret Fegen, Carmen Huesa, Anne Crilly, Gary J. Litherland
Exercise is recommended as a non-pharmacological therapy for osteoarthritis (OA). Clinical studies investigating the impact of exercise on OA have primarily focussed on the assessment of joint pain and mobilisation, where positive outcomes have been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e95591aacebde0d7cc039d36fc4ddad8
https://doi.org/10.21203/rs.3.rs-1054109/v1
https://doi.org/10.21203/rs.3.rs-1054109/v1
Autor:
MC Butcher, Lorraine Martin, Gary J. Litherland, C Delaney, G Ramage, C. Williams, B Short, WG Mackay, Keith D. Thornbury
Publikováno v:
New insights into airways disease.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c5de15c580bbc2809758ab34ee6335fe
https://doi.org/10.1136/thorax-2021-btsabstracts.95
https://doi.org/10.1136/thorax-2021-btsabstracts.95
Autor:
Joanna Brzeszczynska, Lorcan McGarvey, Gary J. Litherland, Anne Crilly, Kimberly Black, John C. Lockhart, Keith D. Thornbury, Lynette Dunning, Carl S. Goodyear, Andrew MacKenzie
Publikováno v:
Irish Journal of Medical Science (1971 -). 188:255-320
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::328b81c6798c8026ce5d152ab5c36a37
https://doi.org/10.1007/s11845-019-02123-3
https://doi.org/10.1007/s11845-019-02123-3