Zobrazeno 1 - 10
of 265
pro vyhledávání: '"J, Lasch"'
Publikováno v:
Journal of Lipid Research, Vol 38, Iss 11, Pp 2374-2379 (1997)
In the presence of ortho-phthalaldehyde and glucosamine, thiolipids form fluorescent isoindole derivatives. This reaction can be used to quantify single- and double-chain mercaptans in membranes (liposomes) and micellar solutions. The lower detection
Externí odkaz:
https://doaj.org/article/a8b35b0cc39d457fb193201a083fbe21
Autor:
Pamela A. Trail, Harold Mastalerz, Raymond A. Firestone, David Willner, Hofstead Sandra J, Shirley J. Lasch, Dalton King, Gene M. Dubowchik
Publikováno v:
Journal of Medicinal Chemistry. 45:4336-4343
High mole ratio BR96 immunoconjugates were synthesized using branched peptide-doxorubicin linkers designed to liberate doxorubicin following antigen-specific internalization into lysosomes. However, these immunoconjugates are highly prone to noncoval
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d29fb0884a9989d4a2ec907eb30cf07f
https://doi.org/10.1021/jm020149g
https://doi.org/10.1021/jm020149g
Autor:
Michael A. Walker, Shilpa Radia, Dalton King, Shirley J. Lasch, David Willner, Hofstead Sandra J, Gene M. Dubowchik, Harold Mastalerz, Raymond A. Firestone, Pamela A. Trail
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 12:1529-1532
Bivalent doxorubicin (DOX)-dipeptides ( 16a – c ) were prepared and conjugated to the monoclonal antibody BR96. The dipeptides are cleaved by lysosomal proteases following internalization of the resulting immunoconjugates. Conjugate 18b demonstrate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::933401d420d7b01374ef7d812e2fa84b
https://doi.org/10.1016/s0960-894x(02)00194-4
https://doi.org/10.1016/s0960-894x(02)00194-4
Autor:
Karl Erik Hellström, Yurgaitis D, David Willner, King Hd, Pamela A. Trail, Raymond A. Firestone, Yang Mb, Shirley J. Lasch
Publikováno v:
Bioconjugate Chemistry. 10:279-288
Immunoconjugates of monoclonal antibody BR96 and Doxorubicin have been prepared using a novel series of branched hydrazone linkers. Since each linker bound to the mAb carries two DOX molecules, the DOX/mAb molar ratios of these conjugates were approx
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81f98627ed9d52e720395d8f7c140b81
https://doi.org/10.1021/bc980100i
https://doi.org/10.1021/bc980100i
Publikováno v:
Journal of Microscopy. 191:177-186
We used cryo-TEM to examine the morphology of vesicles formed from lipids of the human stratum corneum (hSC). Human stratum corneum lipid liposomes (hSCLLs) were prepared in buffer at various pH values, using different preparation methods (film metho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::90af6a5935b8ba45cc49992607ddc1ec
https://doi.org/10.1046/j.1365-2818.1998.00369.x
https://doi.org/10.1046/j.1365-2818.1998.00369.x
Autor:
David Willner, Gary R. Braslawsky, Greenfield Robert S, Shirley J. Lasch, Anna Maria Casazza, Hofstead Sandra J, Ingegerd Hellström, Raymond A. Firestone, Karl Erik Hellström, Pamela A. Trail, Arris J. Henderson, Takushi Kaneko, King Hd
Publikováno v:
Journal of Controlled Release. 39:251-259
BR96-Dox is an immunoconjugate (IC) in which doxorubicin (8 equivalents) is linked via an acid-labile hydrazone to the chimeric MAb BR96. It binds to a modified Le y Ag on tumor cells, which then internalize it via endocytosis into lysosomes. There,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5c9bd0cf5063635932136c3bfc6102d4
https://doi.org/10.1016/0168-3659(95)00160-3
https://doi.org/10.1016/0168-3659(95)00160-3
Publikováno v:
Der Pathologe. 16:120-127
HHV-6-infizierte Zellkulturlinien (HSB 2 T-Zellen; HDLM 2-Hodgkin-Zellen) sowie Biopsieproben von HHV-6-positiven Hodgkin(HD)- und Kikuchi-Lymphomen (KL) wurden immunhistologisch auf eine Expression der Genprodukte ras, bcl-2 und p 53 untersucht und
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc1d10f03a7205ec3c9637ad2e501aea
https://doi.org/10.1007/s002920050084
https://doi.org/10.1007/s002920050084
Autor:
P. Kwiatkowski, J. Lasch, T.Q Flood, L. Chiang, Raj K. Chadha, D. Knowles, J. Crano, Gary Siuzdak, R. Ross
Publikováno v:
Acta Crystallographica Section B Structural Science. 50:772-779
Dimethoxy-l',3',3'-trimethylspiro(2H- 1,4- benzoxazine-2,2'-indoline), C2oH=N203, Mr = 338.4, monoclinic, P2~/c, a = 12.151 (2), b = 12.090 (4), c = 24.836 (4) A, fl = 90.31 (1) °, V = 3648 (2) A 3, Z= 8, Dx = 1.23 Mg m- 3, a(Cu Ka) = 1.54178 A, /x
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1150771213b39dbe8dc21874001c24de
https://doi.org/10.1107/s0108768194005938
https://doi.org/10.1107/s0108768194005938
Autor:
David Willner, Greenfield Robert S, Shirley J. Lasch, Hofstead Sandra J, Pamela A. Trail, King Hd, Raymond A. Firestone, Takushi Kaneko, Braslawsky Gary R
Publikováno v:
Bioconjugate Chemistry. 4:521-527
The (6-maleimidocaproyl)hydrazone of doxorubicin was synthesized and conjugated to several mAbs, including chimeric BR96, via a Michael addition reaction to thiol-containing mAbs. DTT reduction of disulfides present in the mAb was a reliable and gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d376fa23fd2adcf44afcec9d99262a04
https://doi.org/10.1021/bc00024a015
https://doi.org/10.1021/bc00024a015
Autor:
Andrew J. Staab, Derek Yurgaitis, Kahnie Pham-Kaplita, Shirley J. Lasch, Pamela A. Trail, Dalton King, Raymond A. Firestone
Publikováno v:
Bioorganicmedicinal chemistry letters. 13(13)
The 6-maleimidocaproylhydrazone derivatives of highly potent antitumor agents 5-Diacetoxypentyldoxorubicin and Morpholinodoxorubicin were synthesized and conjugated to monoclonal antibody BR96 and control IgG. Immunoconjugate molar ratios were genera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd5e2e3a63413bd4817a3ceafebe1ad2
https://pubmed.ncbi.nlm.nih.gov/12798317
https://pubmed.ncbi.nlm.nih.gov/12798317