Zobrazeno 1 - 10
of 1 585
pro vyhledávání: '"J, Lacroix"'
Autor:
Osita U. Ezenwosu, John O. Olawepo, Lorraine J. Lacroix-Willliamson, Ijeoma U. Itanyi, Amaka Ogidi, Tonia C. Onyeka, Madeline Gully, Maisha Gregory, Janis L. Breeze, Stephanie Ibemere, Ngozi Idemili-Aronu, Beth E. Molnar, Echezona E. Ezeanolue
Publikováno v:
BMC Pregnancy and Childbirth, Vol 24, Iss 1, Pp 1-9 (2024)
Abstract Background Pregnancy presents a critical period for any maternal and child health intervention that may impact the health of the newborn. With low antenatal care attendance by pregnant women in health facilities in Nigeria, community-based p
Externí odkaz:
https://doaj.org/article/78bc802ea7aa4f0abeef24aadba3e8dd
Publikováno v:
Cell Reports, Vol 42, Iss 8, Pp 112837- (2023)
Summary: Mechanical forces are thought to activate mechanosensitive PIEZO channels by changing the conformation of a large transmembrane blade domain. Yet, whether different stimuli induce identical conformational changes in this domain remains uncle
Externí odkaz:
https://doaj.org/article/5cc7e352908f4168a7b3e3597a0ccdf1
Autor:
Harriet Dashnow, Brent S. Pedersen, Laurel Hiatt, Joe Brown, Sarah J. Beecroft, Gianina Ravenscroft, Amy J. LaCroix, Phillipa Lamont, Richard H. Roxburgh, Miriam J. Rodrigues, Mark Davis, Heather C. Mefford, Nigel G. Laing, Aaron R. Quinlan
Publikováno v:
Genome Biology, Vol 23, Iss 1, Pp 1-20 (2022)
Abstract Expansions of short tandem repeats (STRs) cause many rare diseases. Expansion detection is challenging with short-read DNA sequencing data since supporting reads are often mapped incorrectly. Detection is particularly difficult for “novel
Externí odkaz:
https://doaj.org/article/b354d34ff2e44f32a24f0158d94420d9
Autor:
Wesley M. Botello-Smith, Wenjuan Jiang, Han Zhang, Alper D. Ozkan, Yi-Chun Lin, Christine N. Pham, Jérôme J. Lacroix, Yun Luo
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Besides mechanical forces, the mechanosensitive channel Piezo1 is activated by the small molecule Yoda1 through an unknown mechanism. Here, using molecular dynamics simulations, calcium imaging and electrophysiology, the authors identify an allosteri
Externí odkaz:
https://doaj.org/article/8c1aeda44ea9466cae5d0b05d2bf2fe1
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Piezo ion channels transduce mechanical stimuli into biological signals but the underlying mechanism has remained elusive. Here, the authors use the selective agonist Yoda1 to identify molecular determinants of Piezo activation, providing mechanistic
Externí odkaz:
https://doaj.org/article/3a4609bc5a3f476f90902b6c75f467b5
Autor:
F. Leclerc, J. Lacroix
Publikováno v:
Perfectionnement en Pédiatrie. 5:151-158
Publikováno v:
Current Sports Medicine Reports. 21:355-357
Publikováno v:
Journal of General Physiology. 155
Mechanosensitive PIEZO1 ion channels open in response to membrane stretch. Yet, the underlying microscopic mechanism of this activation remains unknown. To probe this mechanism, we used cell-attached pressure-clamp recordings to measure single channe
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(29)
Piezo1 channels are essential mechanically activated ion channels in vertebrates. Their selective activation by the synthetic chemical activator Yoda1 opened new avenues to probe their gating mechanisms and develop novel pharmaceuticals. Yet, the nat
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