Zobrazeno 1 - 10
of 510
pro vyhledávání: '"J, LEIN"'
Autor:
Peter M. Andrew, Jeremy A. MacMahon, Pedro N. Bernardino, Yi-Hua Tsai, Brad A. Hobson, Valerie A. Porter, Sydney L. Huddleston, Audrey S. Luo, Donald A. Bruun, Naomi H. Saito, Danielle J. Harvey, Amy Brooks-Kayal, Abhijit J. Chaudhari, Pamela J. Lein
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-20 (2024)
Abstract Acute intoxication with cholinesterase inhibiting organophosphates (OP) can produce life-threatening cholinergic crisis and status epilepticus (SE). Survivors often develop long-term neurological consequences, including spontaneous recurrent
Externí odkaz:
https://doaj.org/article/3f99993abd09479a92b74806ea8f1398
Autor:
Melanie A. Reuter, Madelynn Tucker, Zara Marfori, Rahaf Shishani, Jessica Miranda Bustamante, Rosalinda Moreno, Michael L. Goodson, Allison Ehrlich, Ameer Y. Taha, Pamela J. Lein, Nikhil Joshi, Ilana Brito, Blythe Durbin-Johnson, Renu Nandakumar, Bethany P. Cummings
Publikováno v:
Gut Microbes, Vol 16, Iss 1 (2024)
ABSTRACTBile acids (BA) are among the most abundant metabolites produced by the gut microbiome. Primary BAs produced in the liver are converted by gut bacterial 7-α-dehydroxylation into secondary BAs, which can differentially regulate host health vi
Externí odkaz:
https://doaj.org/article/a2e0617ddb494a5099979126d2fc15aa
Autor:
Yi-Hua Tsai, Eduardo A. González, Ana C. G. Grodzki, Donald A. Bruun, Naomi H. Saito, Danielle J. Harvey, Pamela J. Lein
Publikováno v:
Frontiers in Toxicology, Vol 6 (2024)
Acute intoxication with high levels of organophosphate (OP) cholinesterase inhibitors can cause cholinergic crisis, which is associated with acute, life-threatening parasympathomimetic symptoms, respiratory depression and seizures that can rapidly pr
Externí odkaz:
https://doaj.org/article/9804b0244b1e40a5a4918862ce904b52
Autor:
Donald A. Bruun, Betty Ma, Yi‐Je Chen, Chun‐Yi Wu, Monica Aleman, Dorota Zolkowska, Suzette M. Smiley‐Jewell, Michael A. Rogawski, Pamela J. Lein
Publikováno v:
Epilepsia Open, Vol 8, Iss 2, Pp 666-672 (2023)
Abstract The neurosteroid allopregnanolone (ALLO) is under investigation as a treatment for benzodiazepine‐refractory status epilepticus (SE). Here, we assess the cardiopulmonary safety of intravenous ALLO by itself and after a clinically recommend
Externí odkaz:
https://doaj.org/article/b46ab8137891425b998225dccd024a77
Autor:
Simone Sandoval, Keegan Malany, Krista Thongphanh, Clarisa A. Martinez, Michael L. Goodson, Felipe Da Costa Souza, Lo-Wei Lin, Nicolle Sweeney, Jamie Pennington, Pamela J. Lein, Nancy I. Kerkvliet, Allison K. Ehrlich
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Neuropilin-1 (Nrp1), a transmembrane protein expressed on CD4+ T cells, is mostly studied in the context of regulatory T cell (Treg) function. More recently, there is increasing evidence that Nrp1 is also highly expressed on activated effector T cell
Externí odkaz:
https://doaj.org/article/d48b9f3552214f5a9ed92d0bdbd37bc0
Autor:
Pedro N. Bernardino, Brad A. Hobson, Sydney L. Huddleston, Peter M. Andrew, Jeremy A. MacMahon, Naomi H. Saito, Valerie A. Porter, Donald A. Bruun, Danielle J. Harvey, Joel R. Garbow, Angie Gelli, Abhijit J. Chaudhari, Pamela J. Lein
Publikováno v:
Neurobiology of Disease, Vol 187, Iss , Pp 106316- (2023)
Acute organophosphate (OP) intoxication can trigger seizures that progress to status epilepticus (SE), and survivors often develop chronic morbidities, including spontaneous recurrent seizures (SRS). The pathogenic mechanisms underlying OP-induced SR
Externí odkaz:
https://doaj.org/article/cf4eedabf6fd4818801f2e454472f2db
Publikováno v:
Frontiers in Neurology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/1ee78bb3ea3e42ada6d102dd7c43b80c
Autor:
Peter M. Andrew, Wei Feng, Jonas J. Calsbeek, Shane P. Antrobus, Gennady A. Cherednychenko, Jeremy A. MacMahon, Pedro N. Bernardino, Xiuzhen Liu, Danielle J. Harvey, Pamela J. Lein, Isaac N. Pessah
Publikováno v:
Toxics, Vol 12, Iss 4, p 263 (2024)
Acute intoxication with organophosphorus (OP) cholinesterase inhibitors can produce seizures that rapidly progress to life-threatening status epilepticus. Significant research effort has been focused on investigating the involvement of muscarinic ace
Externí odkaz:
https://doaj.org/article/7fb803086fdf4bbcb9efc66337280bca
Autor:
Moumita Dutta, Kris M. Weigel, Kelley T. Patten, Anthony E. Valenzuela, Christopher Wallis, Keith J. Bein, Anthony S. Wexler, Pamela J. Lein, Julia Yue Cui
Publikováno v:
Toxicology Reports, Vol 9, Iss , Pp 432-444 (2022)
Background: Traffic-related air pollution (TRAP) is linked to increased risk for age-related dementia, including Alzheimer’s disease (AD). The gut microbiome is posited to influence AD risk, and an increase in microbial-derived secondary bile acids
Externí odkaz:
https://doaj.org/article/e56d621f192d432a847ebf3988b119c5
Autor:
Michelle Guignet, Martin Schmuck, Danielle J. Harvey, Danh Nguyen, Donald Bruun, Angela Echeverri, Gene Gurkoff, Pamela J. Lein
Publikováno v:
Heliyon, Vol 9, Iss 2, Pp e13449- (2023)
The field of cell biology has seen major advances in both cellular imaging modalities and the development of automated image analysis platforms that increase rigor, reproducibility, and throughput for large imaging data sets. However, there remains a
Externí odkaz:
https://doaj.org/article/9ba4d4a422c3426f9c9ab8e78480b2c1