Zobrazeno 1 - 10
of 39
pro vyhledávání: '"J, Kunchandy"'
Publikováno v:
Anti-cancer drug design. 10(4)
In an effort to prepare effective non-steroidal antiestrogens without intrinsic estrogenicity and with greater antagonism than those of the triarylethylenes (tamoxifen; TAM) four N-substituted (Z)-1,1-dichloro-2-[4-(2-aminoethoxy)phenyl]-3-phenylcycl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::19744a8c174be1d7600fa4acd4695254
https://pubmed.ncbi.nlm.nih.gov/7786397
https://pubmed.ncbi.nlm.nih.gov/7786397
Autor:
Shrinivas K. Kulkarni, J. Kunchandy
Publikováno v:
Psychopharmacology. 93:113-117
The protective effect of various alpha 2 adrenoceptor agonists such as clonidine, guanfacine, B-HT 920 and ICI 106270 was investigated against Ro 5-4864-induced convulsions in mice and rats. Clonidine and ICI 106270 exhibited a profound anticonvulsan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09704e054ddc7936f64f4c374f7973d9
https://doi.org/10.1007/bf02439596
https://doi.org/10.1007/bf02439596
Autor:
J, Kunchandy, S K, Kulkarni
Publikováno v:
Archives internationales de pharmacodynamie et de therapie. 292
Various alpha 2-agonists such as clonidine, guanfacine, B-HT 920 and ICI 106270 were investigated for their effect in hypoxic stress in rats and mice. Pretreatment with alpha 2-adrenoceptor agonists exhibited a yohimbine sensitive antistress effect a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6b2554973078d459a234aab31ff7afe9
https://pubmed.ncbi.nlm.nih.gov/2899423
https://pubmed.ncbi.nlm.nih.gov/2899423
Publikováno v:
Archives internationales de pharmacodynamie et de therapie. 279(2)
Clonidine (0.1-1.0 mg/kg, i.p.) exhibited anti-inflammatory activity in carrageenan-, formalin-, 5-HT- and histamine-induced paw oedema in rats. Similarly, other two alpha 2-adrenoceptor agonists, guanfacine and B-HT 920, also displayed an anti-infla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::15c4c1b6ee75c7af724febfe7b704e5d
https://pubmed.ncbi.nlm.nih.gov/3516094
https://pubmed.ncbi.nlm.nih.gov/3516094
Publikováno v:
Archives internationales de pharmacodynamie et de therapie. 294
Effect of acute administration of a benzodiazepine-inverse agonist, FG-7142, on forced swimming-induced depression was investigated in mice. A single injection of FG-7142 (40 mg/kg) showed a delayed increase in behavioral despair, the peak effect bei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e6c3a293a512772a636f1805c7b13cd9
https://pubmed.ncbi.nlm.nih.gov/2852932
https://pubmed.ncbi.nlm.nih.gov/2852932
Autor:
J, Kunchandy, S K, Kulkarni
Publikováno v:
Methods and findings in experimental and clinical pharmacology. 9(2)
Various benzodiazepines (BZs) were investigated for their analgesic effect by the tail-flick method in mice. Central type BZ-receptor agonists such as clonazepam, chlordiazepoxide and diazepam showed analgesia while the peripheral BZ-receptor binding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8a8bc94630d875eee9af9fed31f6314b
https://pubmed.ncbi.nlm.nih.gov/3035297
https://pubmed.ncbi.nlm.nih.gov/3035297
Publikováno v:
Indian journal of experimental biology. 25(2)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3af5f6f57f4ea73925bcd72fea040ce3
https://pubmed.ncbi.nlm.nih.gov/3666805
https://pubmed.ncbi.nlm.nih.gov/3666805
Autor:
J, Kunchandy, S K, Kulkarni
Publikováno v:
Indian journal of experimental biology. 26(8)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7117b76998a3855aed60adca0cc8cc34
https://pubmed.ncbi.nlm.nih.gov/2904410
https://pubmed.ncbi.nlm.nih.gov/2904410
Autor:
J, Kunchandy, S K, Kulkarni
Publikováno v:
Methods and findings in experimental and clinical pharmacology. 8(9)
The in vivo equivalent pA2 values for benzodiazepine (BZ) antagonists Ro15-1788 and CGS 8216 were estimated using diazepam as agonist. ED50 value of diazepam was established against pentylenetetrazole-induced seizures in rats. This value was raised b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e999111a469303ea67f173e8e79c1507
https://pubmed.ncbi.nlm.nih.gov/3022084
https://pubmed.ncbi.nlm.nih.gov/3022084
Publikováno v:
Archives internationales de pharmacodynamie et de therapie. 275(1)
The antisecretory and gastric ulcer protective effects of clonidine were studied in four different experimental models in rats. The effects were compared with two other alpha2 agonists guanfacine and B-HT 920 at equimolar dose basis. Clonidine (0.05-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f70ab4c4018b5f6bccb34afa248bc936
https://pubmed.ncbi.nlm.nih.gov/2862848
https://pubmed.ncbi.nlm.nih.gov/2862848