Zobrazeno 1 - 10
of 757
pro vyhledávání: '"J, Konrad"'
Publikováno v:
Journal of Lipid Research, Vol 65, Iss 7, Pp 100578- (2024)
Apolipoprotein AV (APOA5) deficiency causes hypertriglyceridemia in mice and humans. For years, the cause remained a mystery, but the mechanisms have now come into focus. Here, we review progress in defining APOA5’s function in plasma triglyceride
Externí odkaz:
https://doaj.org/article/ba432e2b34da47a29cf2e0d0481cba7a
Autor:
William G. Hoffmann, Yan Q. Chen, Charles S. Schwartz, Jacob L. Barber, Prasun K. Dev, Riley J. Reasons, Juan S. Miranda Maravi, Bridget Armstrong, Robert E. Gerszten, Günther Silbernagel, Robert J. Konrad, Claude Bouchard, Mark A. Sarzynski
Publikováno v:
Journal of Lipid Research, Vol 65, Iss 2, Pp 100495- (2024)
Angiopoietin-like protein (ANGPTL) complexes 3/8 and 4/8 are established inhibitors of LPL and novel therapeutic targets for dyslipidemia. However, the effects of regular exercise on ANGPTL3/8 and ANGPTL4/8 are unknown. We characterized ANGPTL3/8 and
Externí odkaz:
https://doaj.org/article/c80e12bbb63f48e2af9a00413e84aaba
Publikováno v:
Journal of Lipid Research, Vol 64, Iss 12, Pp 100467- (2023)
Externí odkaz:
https://doaj.org/article/442ac65f7c3b48a9b5bac03a0dc81781
Autor:
Yan Q. Chen, Eugene Y. Zhen, Anna M. Russell, Mariam Ehsani, Robert W. Siegel, Yuewei Qian, Robert J. Konrad
Publikováno v:
Journal of Lipid Research, Vol 64, Iss 10, Pp 100441- (2023)
After feeding, adipose tissue lipoprotein lipase (LPL) activity should be maximized, therefore the potent LPL-inhibitory activity of angiopoietin-like protein 4 (ANGPTL4) must be blocked by ANGPTL8 through formation of ANGPTL4/8 complexes. ANGPTL4/8
Externí odkaz:
https://doaj.org/article/fd8e36108a9340d8926ab8efc7ceee8d
Autor:
F. Friedland, S. Babu, R. Springer, J. Konrad, Y. Herfs, S. Gerlach, J. Gehlen, H.-J. Krause, L. De Laporte, R. Merkel, E. Noetzel
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Epithelial cells of human breast glands are exposed to various mechanical ECM stresses that regulate tissue development and homeostasis. Mechanoadaptation of breast gland tissue to ECM-transmitted shear stress remained poorly investigated due to the
Externí odkaz:
https://doaj.org/article/5c97082c08664823989f4a7784147bdf
Publikováno v:
Swiss Medical Weekly, Vol 152, Iss 2526 (2022)
AIMS: Anaesthesia safety has improved over time with severe anaesthesia-related complications and death becoming rare events. We investigated anaesthesia-related complications over a period of 17 years in this single centre retrospective observationa
Externí odkaz:
https://doaj.org/article/8fc5e602989c4894868884f7a0ff035f
Autor:
Deepa Balasubramaniam, Oliver Schroeder, Anna M. Russell, Jonathan R. Fitchett, Aaron K. Austin, Thomas P. Beyer, Yan Q. Chen, Jonathan W. Day, Mariam Ehsani, Aik Roy Heng, Eugene Y. Zhen, Julian Davies, Wolfgang Glaesner, Bryan E. Jones, Robert W. Siegel, Yue-Wei Qian, Robert J. Konrad
Publikováno v:
Journal of Lipid Research, Vol 63, Iss 5, Pp 100198- (2022)
Triglycerides (TG) are required for fatty acid transport and storage and are essential for human health. Angiopoietin-like-protein 8 (ANGPTL8) has previously been shown to form a complex with ANGPTL3 that increases circulating TG by potently inhibiti
Externí odkaz:
https://doaj.org/article/26adf6a9de994f0db3750f1688a02589
Autor:
Yan Q. Chen, Thomas G. Pottanat, Robert W. Siegel, Mariam Ehsani, Yue-Wei Qian, Eugene Y. Zhen, Ajit Regmi, William C. Roell, Haihong Guo, M. Jane Luo, Ruth E. Gimeno, Ferdinand van't Hooft, Robert J. Konrad
Publikováno v:
Journal of Lipid Research, Vol 61, Iss 8, Pp 1203-1220 (2020)
Angiopoietin-like protein (ANGPTL)8 has been implicated in metabolic syndrome and reported to regulate adipose FA uptake through unknown mechanisms. Here, we studied how complex formation of ANGPTL8 with ANGPTL3 or ANGPTL4 varies with feeding to regu
Externí odkaz:
https://doaj.org/article/c72ea3f26d074f9c9c33cf92743a0709
Autor:
Yan Q. Chen, Thomas G. Pottanat, Robert W. Siegel, Mariam Ehsani, Yue-Wei Qian, Robert J. Konrad
Publikováno v:
Heliyon, Vol 7, Iss 9, Pp e07898- (2021)
We previously demonstrated that angiopoietin-like protein 8 (ANGPTL8) forms ANGPTL3/8 and ANGPTL4/8 complexes that increase with feeding to direct fatty acids (FA) toward adipose tissue through differential modulation of lipoprotein lipase (LPL) acti
Externí odkaz:
https://doaj.org/article/7dce298342ee4f6eb9cc6a9575c1bda2
Autor:
Yan Q. Chen, Thomas G. Pottanat, Eugene Y. Zhen, Robert W. Siegel, Mariam Ehsani, Yue-Wei Qian, Robert J. Konrad
Publikováno v:
Journal of Lipid Research, Vol 62, Iss , Pp 100068- (2021)
Abstract: Triglyceride (TG) molecules represent the major storage form of fatty acids, and TG metabolism is essential to human health. However, the mechanistic details surrounding TG metabolism are complex and incompletely elucidated. Although it is
Externí odkaz:
https://doaj.org/article/a91636415dd6420a9b605414ff71d7a8