Small-molecule activation of OGG1 increases oxidative DNA damage repair by gaining a new function

Autor: Maurice Michel, Carlos Benítez-Buelga, Patricia A. Calvo, Bishoy M. F. Hanna, Oliver Mortusewicz, Geoffrey Masuyer, Jonathan Davies, Olov Wallner, Kumar Sanjiv, Julian J. Albers, Sergio Castañeda-Zegarra, Ann-Sofie Jemth, Torkild Visnes, Ana Sastre-Perona, Akhilesh N. Danda, Evert J. Homan, Karthick Marimuthu, Zhao Zhenjun, Celestine N. Chi, Antonio Sarno, Elisée Wiita, Catharina von Nicolai, Anna J. Komor, Varshni Rajagopal, Sarah Müller, Emily C. Hank, Marek Varga, Emma R. Scaletti, Monica Pandey, Stella Karsten, Hanne Haslene-Hox, Simon Loevenich, Petra Marttila, Azita Rasti, Kirill Mamonov, Florian Ortis, Fritz Schömberg, Olga Loseva, Josephine Stewart, Nicholas D’Arcy-Evans, Tobias Koolmeister, Martin Henriksson, Dana Michel, Ana de Ory, Lucia Acero, Oriol Calvete, Martin Scobie, Christian Hertweck, Ivan Vilotijevic, Christina Kalderén, Ana Osorio, Rosario Perona, Alexandra Stolz, Pål Stenmark, Ulrika Warpman Berglund, Miguel de Vega, Thomas Helleday

Publikováno v: Science. 376:1471-1476

Oxidative DNA damage is recognized by 8-oxoguanine (8-oxoG) DNA glycosylase 1 (OGG1), which excises 8-oxoG, leaving a substrate for apurinic endonuclease 1 (APE1) and initiating repair. Here, we describe a small molecule (TH10785) that interacts with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3729c4fdd8e5f18775de3d2f9e81a847
https://doi.org/10.1126/science.abf8980

Ubiquitous bacterial polyketides induce cross-kingdom microbial interactions

Autor: Mario K. C. Krespach, Maria C. Stroe, Tina Netzker, Maira Rosin, Lukas M. Zehner, Anna J. Komor, Johanna M. Beilmann, Thomas Krüger, Olaf Kniemeyer, Volker Schroeckh, Christian Hertweck, Axel A. Brakhage

Although the interaction of prokaryotic and eukaryotic microorganisms is critical for the functioning of ecosystems, knowledge of the processes driving microbial interactions within communities is in its infancy. We previously reported that the soil

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3362ddf6268bf0ef424065e3013c7d9b
https://doi.org/10.1101/2022.05.09.491136

223 Development of Online Surgical Skills Education

Autor: P. Soleimani-Nouri, J. Komor, Bibek. Das, M. Fadel, M. Ahmad

Publikováno v: British Journal of Surgery. 109

Introduction Online teaching rapidly emerged as a viable alternative to traditional face-to-face education. However, how to teach surgical skills in the online environment has not been established nor evaluated yet. Method An international one-day on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::64ba9a46b717ffd46cd0dccc7f5fbcd6
https://doi.org/10.1093/bjs/znac039.139

Medical student engagement with surgery and research during the COVID-19 pandemic: supporting the future workforce for post-pandemic surgical recovery

Autor: Shiraz Q. Shafi, Samuel Brown, Rachel A. Khaw, Johnathan Hirniak, Joshua R. Burke, Lola Giwa, Lorna Marson, Arnold Hill, Dileep Lobo, James C. Glasbey, Kenneth A. McLean, T. Patel, G. Liu, A. Singal, R. Nam, A. Kathiravelupillai, W. L. Chia, S. Z.Y. Ooi, M. Matthews, Subbiah H. Ponniah, J. Komor, A. Heyes, S. Tushingham, D. S. Hettiarachchi, T K, S. Gaier, C. Jordan, A. Joyce, E. Johnston, K. Valentine, K. Nagassima, Rodrigues dos Reis, M. O’Sullivan, A. Tittawella, E. Geary, C. Thorpe, A. H.B. Jalal, M. Georgi, A. Mergo, E. Ramsay, J. Sheikh, A. Ashok, K. S. Lee, R. Risquet, S. Kathiravelupillai, D. Chia, S. Al Majid, Aafreen E. Matloob Ahmad, A. Hounat, S. Shafi, J. Wang, W. A. Cambridge, L. Kawar, T. Maseland, K. Sharma, J. Moses, M. A. Patsalides, S. Brown, A. Jaffer, K. Feeney, G. Richardson, Josiah P. Joseph, L. Argus, X. Sara, A. Antypas, M. de Andres Crespo, E. Daly, S. Abraha

Publikováno v: Shafi, S Q, Brown, S, Khaw, R A, Hirniak, J, Burke, J R, Giwa, L, Marson, L P, Hill, A, Lobo, D, Glasbey, J C, Mclean, K, Patel, T, Liu, G, Singal, A, Nam, R, Kathiravelupillai, A, Chia, W L, Ooi, S ZY, Mathews, M, Subbiah Ponniah, H, Komor, J, Heyes, A, Tushingham, S, Hettiarachchi, D S, K, T, Gaier, S, Jordan, C, Joyce, A, Johnston, E, Valentine, K, Nagassima Rodrigues dos Reis, K, O'Sullivan, M, Tittawella, A, Geary, E, Thorpe, C, Jalal, A HB, Georgi, M, Mergo, A, Ramsay, E, Sheikh, J, Ashok, A, Lee, KS, Al Majid, S, Aafreen Matloob Ahmad, E, Hounat, A, Shafi, S, Wang, J, Cambridge, W A, Kawar, L, Maseland, T, Sharma, K, Moses, J, Patsalides, M A, Brown, S, Jaffer, A, Feeney, K, Richardson, G, Josiah Joseph, P, Argus, L, Sara, X, Antypas, A, de Andres Crespo, M, Daly, E & Abraha, S 2021, ' Medical student engagement with surgery and research during the COVID-19 pandemic: supporting the future workforce for post-pandemic surgical recovery. ', International Journal of Surgery . https://doi.org/10.1016/j.ijsu.2021.106105

Medical students have lost invaluable exposure to surgery and research during the COVID-19 pandemic, with the majority of placements being cancelled or converted online 1. As such, they have been denied opportunities and mentorship which have histori

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https://www.pure.ed.ac.uk/ws/files/225837175/1_ase_full.docx

245 An Introduction to Surgery: Effectiveness of An Online, Lecture-Based Programme in Providing Surgical Career Guidance for Pre-Clinical Students

Autor: Michal Kawka, M Kelada, J Komor

Publikováno v: British Journal of Surgery. 108

Aim Early exposure to surgery has been found to impact medical students’ decisions to pursue a career in surgery. Despite this, students are often not exposed to surgical specialties until senior years of medical school. The aim of this study was t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1613b2f535bd800f810aa3f3c570131b
https://doi.org/10.1093/bjs/znab259.847