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Akademický článek

Evaluating the performance of the Roche FEN2 fentanyl immunoassay and its clinical implementation: The role of LDT-based mass spectrometry testing

Autor: Marlen Menlyadiev, Raymond T. Suhandynata, Kyle Lund, Michael J. Kelner, Robert L. Fitzgerald

Publikováno v: Journal of Mass Spectrometry and Advances in the Clinical Lab, Vol 28, Iss , Pp 105-113 (2023)

Introduction: While laboratory-developed tests (LDTs) using liquid chromatography tandem mass spectrometry (LC-MS/MS) are widely employed to support the development of FDA-cleared drug immunoassays, their significance in the clinical implementation a

Externí odkaz: https://doaj.org/article/267ef71f9af64947b9fcdff71988ee5c

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Akademický článek

Comparison of two highly sensitive benzodiazepine immunoassay lab developed tests for urine drug testing in clinical specimens

Autor: Kyle Lund, Marlen Menlyadiev, Kyunghoon Lee, Michael J. Kelner, Robert L. Fitzgerald, Raymond T. Suhandynata

Publikováno v: Journal of Mass Spectrometry and Advances in the Clinical Lab, Vol 28, Iss , Pp 91-98 (2023)

Background: The VALID Act is a legislative effort that, if enacted, would alter the regulatory requirements of laboratory developed tests (LDTs) used for clinical testing in the United States. Benzodiazepines, which are primarily excreted into urine

Externí odkaz: https://doaj.org/article/6ccd9e7fe693441ab3323710600f0623

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Akademický článek

MGST1, a GSH transferase/peroxidase essential for development and hematopoietic stem cell differentiation

Autor: Lars Bräutigam, Jie Zhang, Kristian Dreij, Linda Spahiu, Arne Holmgren, Hiroshi Abe, Kenneth D. Tew, Danyelle M. Townsend, Michael J. Kelner, Ralf Morgenstern, Katarina Johansson

Publikováno v: Redox Biology, Vol 17, Iss , Pp 171-179 (2018)

We show for the first time that, in contrast to other glutathione transferases and peroxidases, deletion of microsomal glutathione transferase 1 (MGST1) in mice is embryonic lethal. To elucidate why, we used zebrafish development as a model system an

Externí odkaz: https://doaj.org/article/6112082f1b8143d8bfa088eb5a31f32c

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Akademický článek

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Akademický článek

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Akademický článek

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SARS-CoV-2 Serology Status Detected by Commercialized Platforms Distinguishes Previous Infection and Vaccination Adaptive Immune Responses

Autor: David Nemazee, Steven L. Gonias, Kyle Lund, Deli Huang, Melissa A Hoffman, Robert L. Fitzgerald, Ronald W. McLawhon, Nicholas J Bevins, Michael J. Kelner, Raymond T. Suhandynata, Jenny Tuyet Tran

Publikováno v: The Journal of Applied Laboratory Medicine
medRxiv
article-version (status) pre
article-version (number) 1

Background. The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has infected over 110 million individuals and led to 2.5 million deaths worldwide. As more individuals are vaccinated, the clinical performance and utility of SARS-CoV-2 ser

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ccf9242fa19f7777f0496e4f41d8b81
http://europepmc.org/articles/PMC8409063

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Abstract 5484: Preclinical evaluation of CAP-0121 for multidrug resistant cancers

Autor: Michael J. Kelner, Venkata R. Kotamraju

Publikováno v: Cancer Research. 82:5484-5484

CAP-0121 is a second generation illudofulvene agent that produces an unusual type of DNA damage and is being developed to treat ovarian cancer by Califia Pharma. CAP-0121 DNA damage, like other illudofulvenes, can only be recognized and repaired by t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bbc07f85c3a432219ea1a2904d99be96
https://doi.org/10.1158/1538-7445.am2022-5484

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Commercial Serology Assays Predict Neutralization Activity against SARS-CoV-2

Autor: Michael J. Kelner, Jenny Tuyet Tran, David Nemazee, James E. Voss, Deli Huang, Melissa A Hoffman, Raymond T. Suhandynata, Robert L. Fitzgerald, Ronald W. McLawhon, Sharon L. Reed

Publikováno v: Clinical chemistry, vol 67, iss 2
Clinical Chemistry

BackgroundCurrently it is unknown whether a positive serology results correlates with protective immunity against SARS-CoV-2. There are also concerns regarding the low positive predictive value of SARS-CoV-2 serology tests, especially when testing po

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5bf61e9484594832362e1aef782584c
https://escholarship.org/uc/item/7m37937r

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Real-World Clinical Performance Evaluation of a Fourth-Generation HIV Antigen/Antibody Differentiation Test

Autor: Matthew D. Krasowski, Sihe Wang, Michael J. Kelner, Yi Lauseker-Hao, Susan Smith, Dustin Wier, Alexander Riedel

Publikováno v: The journal of applied laboratory medicine. 6(6)

Background HIV testing is still an important component of routine sexual health screening, assessment of at-risk individuals and as part of the care of pregnant women. To prevent further transmission of infection, it is important that HIV tests are h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e18623428dc4b23056cc5d707d4fe79
https://pubmed.ncbi.nlm.nih.gov/34333654

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