Zobrazeno 1 - 10
of 5 799
pro vyhledávání: '"J, Kaufman"'
Autor:
Michael L. van de Weijer, Krishna Samanta, Nikita Sergejevs, LuLin Jiang, Maria Emilia Dueñas, Tiaan Heunis, Timothy Y. Huang, Randal J. Kaufman, Matthias Trost, Sumana Sanyal, Sally A. Cowley, Pedro Carvalho
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Immune surveillance by cytotoxic T cells eliminates tumor cells and cells infected by intracellular pathogens. This process relies on the presentation of antigenic peptides by Major Histocompatibility Complex class I (MHC-I) at the cell surf
Externí odkaz:
https://doaj.org/article/48a91d8bd1874f4caa6ab396c81c07b0
Autor:
Aline Raquel Vieira Nunes, Sinara Borborema, Caio Marcello F. Azevedo Cossú, Leonardo Sales Araújo, Jean Dille, Loïc Malet, Michael J. Kaufman, Luiz Henrique de Almeida
Publikováno v:
Journal of Materials Research and Technology, Vol 31, Iss , Pp 4104-4112 (2024)
In this study, the influence of thermomechanical treatments on the microstructure and mechanical properties of a new metastable β-titanium Ti-23.6Nb-5.1Mo-6.7Zr alloy was assessed. The objective was to determine if the alloy is a potential candidate
Externí odkaz:
https://doaj.org/article/968481667e544ab289ce64af44bd1740
Autor:
Samuel N Smukowski, Cassidy Danyko, Jenna Somberg, Eli J Kaufman, Meredith M Course, Nadia Postupna, Melissa Barker-Haliski, C Dirk Keene, Paul N Valdmanis
Publikováno v:
PLoS Genetics, Vol 20, Iss 7, p e1011359 (2024)
Proper transport of RNAs to synapses is essential for localized translation of proteins in response to synaptic signals and synaptic plasticity. Alzheimer's disease (AD) is a neurodegenerative disease characterized by accumulation of amyloid aggregat
Externí odkaz:
https://doaj.org/article/2df89832c2e746d691e31f7e13071a67
Publikováno v:
Journal of Family Medicine and Primary Care, Vol 13, Iss 2, Pp 787-791 (2024)
Moderate to severe hypertensive retinopathies are more likely to correlate with uncontrolled blood pressure in all ages. Mild microvascular changes are expected with natural aging and are therefore more concerning in patients younger than 40. Risk as
Externí odkaz:
https://doaj.org/article/86dd19adbcbd44baab0120c217db1483
Autor:
Fang Fang, Pingting Liu, Haoliang Huang, Xue Feng, Liang Li, Yang Sun, Randal J. Kaufman, Yang Hu
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 33, Iss , Pp 286-295 (2023)
Endoplasmic reticulum (ER) stress has been linked with various acute and chronic neurodegenerative diseases. We previously found that optic nerve (ON) injury and diseases induce neuronal ER stress in retinal ganglion cells (RGCs). We further demonstr
Externí odkaz:
https://doaj.org/article/75c581605dcd46cf894c558e0d0ef6d6
Autor:
Rachel C. Avard, Megan L. Broad, Fereshteh Zandkarimi, Alexander J. Devanny, Joseph L. Hammer, Karen Yu, Asja Guzman, Laura J. Kaufman
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-18 (2023)
Abstract Multicellular tumor spheroids embedded in collagen I matrices are common in vitro systems for the study of solid tumors that reflect the physiological environment and complexities of the in vivo environment. While collagen I environments are
Externí odkaz:
https://doaj.org/article/2a3fb023fa5049ce85739b32a3a53e4a
Autor:
James I. Hudson, Yaakov Hudson, Gen Kanyama, Jiana Schnabel, Kristin N. Javaras, Marc J. Kaufman, Harrison G. Pope, Jr.
Publikováno v:
Drug and Alcohol Dependence Reports, Vol 10, Iss , Pp 100215- (2024)
Background: Prior research has demonstrated associations between anabolic-androgenic steroid (AAS) use and features from several childhood and adolescent psychosocial domains including body image concerns, antisocial traits, and low levels of parenta
Externí odkaz:
https://doaj.org/article/b78a2ef5448a4e04a2f975701e14baaa
Autor:
Zhouji Chen, Shiyu Wang, Anita Pottekat, Alec Duffey, Insook Jang, Benny H. Chang, Jaehyung Cho, Brian N. Finck, Nicholas O. Davidson, Randal J. Kaufman
Publikováno v:
Molecular Metabolism, Vol 80, Iss , Pp 101874- (2024)
Objectives: The assembly and secretion of hepatic very low-density lipoprotein (VLDL) plays pivotal roles in hepatic and plasma lipid homeostasis. Protein disulfide isomerase A1 (PDIA1/P4HB) is a molecular chaperone whose functions are essential for
Externí odkaz:
https://doaj.org/article/2eb00029f7a54fa383e62a065aa4cf9b
Autor:
Mehdi Amiri, Stephen J. Kiniry, Anthony P. Possemato, Niaz Mahmood, Tayebeh Basiri, Catherine R. Dufour, Negar Tabatabaei, Qiyun Deng, Michael A. Bellucci, Keerthana Harwalkar, Matthew P. Stokes, Vincent Giguère, Randal J. Kaufman, Yojiro Yamanaka, Pavel V. Baranov, Soroush Tahmasebi, Nahum Sonenberg
Publikováno v:
Cell Reports, Vol 43, Iss 1, Pp 113615- (2024)
Summary: The integrated stress response (ISR) is critical for cell survival under stress. In response to diverse environmental cues, eIF2α becomes phosphorylated, engendering a dramatic change in mRNA translation. The activation of ISR plays a pivot
Externí odkaz:
https://doaj.org/article/18af2fe7b35548578596dd8ed96f88ce
Autor:
Gaëlle Mawambo, Malika Oubaha, Yusuke Ichiyama, Guillaume Blot, Sergio Crespo-Garcia, Agnieszka Dejda, François Binet, Roberto Diaz-Marin, Christina Sawchyn, Mikhail Sergeev, Rachel Juneau, Randal J. Kaufman, El Bachir Affar, Frédérick A. Mallette, Ariel M. Wilson, Przemyslaw Sapieha
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-14 (2023)
Abstract Cellular adaptation to low oxygen tension triggers primitive pathways that ensure proper cell function. Conditions of hypoxia and low glucose are characteristic of injured tissues and hence successive waves of inflammatory cells must be suit
Externí odkaz:
https://doaj.org/article/43e12a5532544c0686ece219c67a0571