Zobrazeno 1 - 10
of 218
pro vyhledávání: '"J, Kahler"'
Autor:
Veronica Davalos, Claudia D. Lovell, Richard Von Itter, Igor Dolgalev, Praveen Agrawal, Gillian Baptiste, David J. Kahler, Elena Sokolova, Sebastian Moran, Laia Piqué, Eleazar Vega-Saenz de Miera, Barbara Fontanals-Cirera, Alcida Karz, Aristotelis Tsirigos, Chi Yun, Farbod Darvishian, Heather C. Etchevers, Iman Osman, Manel Esteller, Markus Schober, Eva Hernando
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Melanocytes can de-differentiate into neural crest cell (NCC)- like states during metastatic melanoma progression. Here the authors compare DNA methylation profiles of NCCs and melanocytes, as well as primary and metastatic patient tissues and identi
Externí odkaz:
https://doaj.org/article/8185f7446ad34fda88510e094a1353e3
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 8, Iss 10, Pp 3293-3309 (2018)
The proper accumulation and maintenance of stem cells is critical for organ development and homeostasis. The Notch signaling pathway maintains stem cells in diverse organisms and organ systems. In Caenorhabditis elegans, GLP-1/Notch activity prevents
Externí odkaz:
https://doaj.org/article/fb3cd279919a447e9a6b942593584252
Publikováno v:
C24. DISPARITIES IN THE HEALTH EFFECTS OF CLIMATE CHANGE AND POLLUTANTS.
Autor:
Yolande Grobler, Chi Y Yun, David J Kahler, Casey M Bergman, Hangnoh Lee, Brian Oliver, Ruth Lehmann
Publikováno v:
PLoS Pathogens, Vol 14, Iss 11, p e1007445 (2018)
Wolbachia is an intracellular bacterium that infects a remarkable range of insect hosts. Insects such as mosquitos act as vectors for many devastating human viruses such as Dengue, West Nile, and Zika. Remarkably, Wolbachia infection provides insect
Externí odkaz:
https://doaj.org/article/4d0e38f144204acd90c8603675d8dff4
Autor:
Paolo Mita, Aleksandra Wudzinska, Xiaoji Sun, Joshua Andrade, Shruti Nayak, David J Kahler, Sana Badri, John LaCava, Beatrix Ueberheide, Chi Y Yun, David Fenyö, Jef D Boeke
Publikováno v:
eLife, Vol 7 (2018)
LINE-1/L1 retrotransposon sequences comprise 17% of the human genome. Among the many classes of mobile genetic elements, L1 is the only autonomous retrotransposon that still drives human genomic plasticity today. Through its co-evolution with the hum
Externí odkaz:
https://doaj.org/article/9d332732d565496f82ee6f605aab31f6
Autor:
Ariadna Giro-Perafita, Marion Failler, Brian David Dynlacht, Mikito Owa, David J. Kahler, Irma Sánchez, Derya Unutmaz, Francisco J. Esteva, Shalini Srivastava, Chi Yun
Publikováno v:
Molecular Biology of the Cell. 32:169-185
We performed a high-throughput whole-genome RNAi screen to identify novel inhibitors of ciliogenesis in normal and basal breast cancer cells. Our screen uncovered a previously undisclosed, extensive network of genes linking integrin signaling and cel
Autor:
Jef D. Boeke, Paolo Mita, David J. Kahler, Chi Yun, Aleksandra Wudzinska, David Fenyö, Xiaoji Sun, Neta Agmon, Donghui Li, Sarah Keegan, Joel S. Bader
Publikováno v:
Nature structural & molecular biology
Long interspersed element-1 (LINE-1, or L1) is the only autonomous retrotransposon that is active in human cells. Different host factors have been shown to influence L1 mobility; however, systematic analyses of these factors are limited. Here, we dev
Autor:
Andrew A Sproul, Samson Jacob, Deborah Pre, Soong Ho Kim, Michael W Nestor, Miriam Navarro-Sobrino, Ismael Santa-Maria, Matthew Zimmer, Soline Aubry, John W Steele, David J Kahler, Alex Dranovsky, Ottavio Arancio, John F Crary, Sam Gandy, Scott A Noggle
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e84547 (2014)
Presenilin 1 (PSEN1) encodes the catalytic subunit of γ-secretase, and PSEN1 mutations are the most common cause of early onset familial Alzheimer's disease (FAD). In order to elucidate pathways downstream of PSEN1, we characterized neural progenito
Externí odkaz:
https://doaj.org/article/044e69604c744103bad968cd9a9fb4bc
Autor:
David J Kahler, Faizzan S Ahmad, Anita Ritz, Haiqing Hua, Dorota N Moroziewicz, Andrew A Sproul, Carmen R Dusenberry, Linshan Shang, Daniel Paull, Matthew Zimmer, Keren A Weiss, Dieter Egli, Scott A Noggle
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e59867 (2013)
Current methods to derive induced pluripotent stem cell (iPSC) lines from human dermal fibroblasts by viral infection rely on expensive and lengthy protocols. One major factor contributing to the time required to derive lines is the ability of resear
Externí odkaz:
https://doaj.org/article/c9bef5c817a749b6994f51cfff61a697
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 8, Iss 10, Pp 3293-3309 (2018)
G3: Genes|Genomes|Genetics
G3: Genes|Genomes|Genetics
The proper accumulation and maintenance of stem cells is critical for organ development and homeostasis. The Notch signaling pathway maintains stem cells in diverse organisms and organ systems. In Caenorhabditis elegans, GLP-1/Notch activity prevents