Zobrazeno 1 - 10
of 389
pro vyhledávání: '"J, Junge"'
Autor:
Lingling Zhang, Md. Abedin, Ha-Neul Jo, Jacklyn Levey, Quynh Chau Dinh, Zhe Chen, Stephane Angers, Harald J. Junge
Publikováno v:
iScience, Vol 26, Iss 8, Pp 107415- (2023)
Summary: Norrin (NDP) and WNT7A/B induce and maintain the blood-brain and blood-retina barrier (BBB, BRB) by stimulating the Frizzled4-LDL receptor related protein 5/6 (FZD4-LRP5/6) complex to induce beta-catenin-dependent signaling in endothelial ce
Externí odkaz:
https://doaj.org/article/fffa45f051214dd5a60a83b32119997b
Publikováno v:
Cell Reports, Vol 42, Iss 5, Pp 112455- (2023)
Summary: Dynamic and coordinated axonal responses to changing environments are critical for establishing neural connections. As commissural axons migrate across the CNS midline, they are suggested to switch from being attracted to being repelled in o
Externí odkaz:
https://doaj.org/article/997150ea60df4c439948c8504190c75c
A Norrin/Wnt surrogate antibody stimulates endothelial cell barrier function and rescues retinopathy
Autor:
Rony Chidiac, Md. Abedin, Graham Macleod, Andy Yang, Pierre E Thibeault, Levi L Blazer, Jarrett J Adams, Lingling Zhang, Heidi Roehrich, Ha‐Neul Jo, Somasekar Seshagiri, Sachdev S Sidhu, Harald J Junge, Stephane Angers
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 7, Pp 1-16 (2021)
Abstract The FZD4:LRP5:TSPAN12 receptor complex is activated by the secreted protein Norrin in retinal endothelial cells and leads to βcatenin‐dependent formation of the blood–retina–barrier during development and its homeostasis in adults. Mu
Externí odkaz:
https://doaj.org/article/823716d920524f3b8debfe84b49df873
Autor:
Hongryeol Park, Hiroyuki Yamamoto, Lucas Mohn, Lea Ambühl, Kenichi Kanai, Inga Schmidt, Kee-Pyo Kim, Alessia Fraccaroli, Silke Feil, Harald J. Junge, Eloi Montanez, Wolfgang Berger, Ralf H. Adams
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Integrin-linked kinase (ILK) is an important mediator of integrin signaling. Here Park et al. show that mice with endothelial-specific deletion of Ilk develop vascular defects that resemble familial exudative vitreoretinopathy, and identify mutations
Externí odkaz:
https://doaj.org/article/584556069c6146ea98a94e8f212f9037
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Multiple mechanisms regulate Wnt/ß-catenin signalling. Zhanget al. describe a novel regulatory pathway and show that the activator of canonical Wnt signalling, Norrin, triggers endocytosis of its receptor Frizzled4 by promoting Frizzled4 ubiquitinat
Externí odkaz:
https://doaj.org/article/42e7520136c84382908bf58215d8f91e
Autor:
Maria B. Lai, Chi Zhang, Jianli Shi, Verity Johnson, Lavan Khandan, John McVey, Michael W. Klymkowsky, Zhe Chen, Harald J. Junge
Publikováno v:
Cell Reports, Vol 19, Iss 13, Pp 2809-2822 (2017)
Accessory proteins in Frizzled (FZD) receptor complexes are thought to determine ligand selectivity and signaling amplitude. Genetic evidence indicates that specific combinations of accessory proteins and ligands mediate vascular β-catenin signaling
Externí odkaz:
https://doaj.org/article/af24154b07914062a601ee51ffff3106
Publikováno v:
eLife, Vol 8 (2019)
Proper connectivity of the nervous system requires temporal and spatial control of axon guidance signaling. As commissural axons navigate across the CNS midline, ROBO-mediated repulsion has traditionally been thought to be repressed before crossing,
Externí odkaz:
https://doaj.org/article/88d77f9eb01d40d1ab8413c685b5b857
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Publikováno v:
New Journal of Chemistry. 46:572-581
This work investigated the properties of a four-component molecular ensemble, in which a carbazole (CBz) donor and a benzothiadiazole (BTD) acceptor are connected through a phenylthiophene (PT) bridge. The multiple rotational freedoms at the C--C sin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3d3ae95943552d0cfb60ec9582abc7ba
https://doi.org/10.1039/d1nj04274b
https://doi.org/10.1039/d1nj04274b
Autor:
Yuhki Saito, Soledad Miranda-Rottmann, Matteo Ruggiu, Christopher Y Park, John J Fak, Ru Zhong, Jeremy S Duncan, Brian A Fabella, Harald J Junge, Zhe Chen, Roberto Araya, Bernd Fritzsch, A J Hudspeth, Robert B Darnell
Publikováno v:
eLife, Vol 5 (2016)
The neuron specific RNA-binding proteins NOVA1 and NOVA2 are highly homologous alternative splicing regulators. NOVA proteins regulate at least 700 alternative splicing events in vivo, yet relatively little is known about the biologic consequences of
Externí odkaz:
https://doaj.org/article/53a008d0115a4c659aae01c373fb5e9f