Zobrazeno 1 - 10
of 2 399
pro vyhledávání: '"J, Houghton"'
Autor:
Isabelle R. Onley, Melissa J. Houghton, Kirsten Leggett, Phill Cassey, Zachary T. Carter, Justine Shaw
Publikováno v:
NeoBiota, Vol 95, Iss , Pp 133-147 (2024)
The continent of Antarctica has remained relatively free of the impacts of invasive species to date. However, Antarctica is under increasing anthropogenic pressure from human activity and climate change, elevating the risk of alien species introducti
Externí odkaz:
https://doaj.org/article/4637c062e2954dd3bd527795e3c56985
Publikováno v:
eLife, Vol 12 (2024)
Biological synaptic transmission is unreliable, and this unreliability likely degrades neural circuit performance. While there are biophysical mechanisms that can increase reliability, for instance by increasing vesicle release probability, these mec
Externí odkaz:
https://doaj.org/article/08dbd6104404401eaf5e610ced0ffb47
Autor:
Kruthi Suvarna, Panneerselvam Jayabal, Xiuye Ma, Hu Wang, Yidong Chen, Susan T. Weintraub, Xianlin Han, Peter J. Houghton, Yuzuru Shiio
Publikováno v:
Cell Reports, Vol 43, Iss 8, Pp 114497- (2024)
Summary: Ewing sarcoma is a cancer of bone and soft tissue in children and young adults primarily driven by the EWS-FLI1 fusion oncoprotein, which has been undruggable. Here, we report that Ewing sarcoma depends on secreted sphingomyelin phosphodiest
Externí odkaz:
https://doaj.org/article/27da5815e62a4b5a8646c0cebf73abc7
Autor:
Isabel G. Martinez, Michael J. Houghton, Matteo Forte, Gary Williamson, Jessica R. Biesiekierski, Ricardo J.S. Costa
Publikováno v:
Heliyon, Vol 10, Iss 13, Pp e33497- (2024)
This study aimed to develop a low-fructose (
Externí odkaz:
https://doaj.org/article/b6de218711bd4da1bfaaeb0179213306
Autor:
Silvia Pomella, Matteo Cassandri, Lucrezia D’Archivio, Antonella Porrazzo, Cristina Cossetti, Doris Phelps, Clara Perrone, Michele Pezzella, Antonella Cardinale, Marco Wachtel, Sara Aloisi, David Milewski, Marta Colletti, Prethish Sreenivas, Zoë S. Walters, Giovanni Barillari, Angela Di Giannatale, Giuseppe Maria Milano, Cristiano De Stefanis, Rita Alaggio, Sonia Rodriguez-Rodriguez, Nadia Carlesso, Christopher R. Vakoc, Enrico Velardi, Beat W. Schafer, Ernesto Guccione, Susanne A. Gatz, Ajla Wasti, Marielle Yohe, Myron Ignatius, Concetta Quintarelli, Janet Shipley, Lucio Miele, Javed Khan, Peter J. Houghton, Francesco Marampon, Berkley E. Gryder, Biagio De Angelis, Franco Locatelli, Rossella Rota
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-23 (2023)
Abstract Rhabdomyosarcomas (RMS) are pediatric mesenchymal-derived malignancies encompassing PAX3/7-FOXO1 Fusion Positive (FP)-RMS, and Fusion Negative (FN)-RMS with frequent RAS pathway mutations. RMS express the master myogenic transcription factor
Externí odkaz:
https://doaj.org/article/b02d638fdabc4c31acb1630b1acf4c96
Autor:
Funan He, Abhik M. Bandyopadhyay, Laura J. Klesse, Anna Rogojina, Sang H. Chun, Erin Butler, Taylor Hartshorne, Trevor Holland, Dawn Garcia, Korri Weldon, Luz-Nereida Perez Prado, Anne-Marie Langevin, Allison C. Grimes, Aaron Sugalski, Shafqat Shah, Chatchawin Assanasen, Zhao Lai, Yi Zou, Dias Kurmashev, Lin Xu, Yang Xie, Yidong Chen, Xiaojing Wang, Gail E. Tomlinson, Stephen X. Skapek, Peter J. Houghton, Raushan T. Kurmasheva, Siyuan Zheng
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Subcutaneous patient-derived xenografts (PDXs) are an important tool for childhood cancer research. Here, we describe a resource of 68 early passage PDXs established from 65 pediatric solid tumor patients. Through genomic profiling of paired
Externí odkaz:
https://doaj.org/article/7acada1d5c1a4ea691eda4a7f049f2e0
Autor:
Rapson Gomez, Stephen J Houghton
Publikováno v:
Behavioral Sciences, Vol 14, Iss 7, p 598 (2024)
Difficulties in emotion regulation (DER) is a defining feature of attention deficit hyperactivity disorder (ADHD), and arguments are being made for it to be considered as a defining feature of oppositional defiant disorder (ODD). However, the consens
Externí odkaz:
https://doaj.org/article/ae535ae0e1634d91ae336e580d5bdac3
Autor:
Anna Rogojina, Laura J. Klesse, Erin Butler, Jiwoong Kim, He Zhang, Xue Xiao, Lei Guo, Qinbo Zhou, Taylor Hartshorne, Dawn Garcia, Korri Weldon, Trevor Holland, Abhik Bandyopadhyay, Luz Perez Prado, Shidan Wang, Donghan M. Yang, Anne-Marie Langevan, Yi Zou, Allison C. Grimes, Chatchawin Assanasen, Vinod Gidvani-Diaz, Siyuan Zheng, Zhao Lai, Yidong Chen, Yang Xie, Gail E. Tomlinson, Stephen X. Skapek, Raushan T. Kurmasheva, Peter J. Houghton, Lin Xu
Publikováno v:
iScience, Vol 26, Iss 11, Pp 108171- (2023)
Summary: Patient-derived xenografts (PDX) remain valuable models for understanding the biology and for developing novel therapeutics. To expand current PDX models of childhood leukemia, we have developed new PDX models from Hispanic patients, a subgr
Externí odkaz:
https://doaj.org/article/22cacf03f3b04f17bc8080bce501067f
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
The biological underpinnings underlying the increased mortality and morbidity in adolescents and young adults (AYA) remains poorly understood. Here, the authors investigate the clinical and genomic disparities in AYA and older adults in a cohort of m
Externí odkaz:
https://doaj.org/article/d9847abffbf94c4b90a7503c8725b748
Publikováno v:
Cell Reports, Vol 42, Iss 6, Pp 112568- (2023)
Summary: The centromere is essential for ensuring high-fidelity transmission of chromosomes. CENP-A, the centromeric histone H3 variant, is thought to be the epigenetic mark of centromere identity. CENP-A deposition at the centromere is crucial for p
Externí odkaz:
https://doaj.org/article/419be356bb984dfd8fb34254d914bb6a