Zobrazeno 1 - 10
of 73
pro vyhledávání: '"J, Hamzik"'
Publikováno v:
The Journal of Organic Chemistry. 85:548-563
A convergent strategy for the synthesis of multisubstituted pyridines is described. Vinylallenes combine with commercially available arylsulfonyl cyanides in Diels-Alder cycloadditions to generate isopyridine cycloadducts that are converted to pyridi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e13a3363a9c39d6d9d64756ae3f5188
https://doi.org/10.1021/acs.joc.9b02628
https://doi.org/10.1021/acs.joc.9b02628
Publikováno v:
Organic Letters. 20:6244-6249
Two methods for the synthesis of multisubstituted pyridines are described. In each strategy, a highly reactive vinylallene is generated via an intramolecular propargylic ene reaction in the presence of an azadienophile. Reactions employing ethyl N-(t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5679c70cb6bd0ebaf5c45bae36a38641
https://doi.org/10.1021/acs.orglett.8b02728
https://doi.org/10.1021/acs.orglett.8b02728
Publikováno v:
The Journal of Organic Chemistry. 82:12975-12991
Metal-free, formal [2 + 2 + 2] cycloaddition strategies for the synthesis of polycyclic pyridine derivatives are described. The overall transformation proceeds via a two-stage pericyclic cascade mechanism. In the first step, an intramolecular proparg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60c1455de3beed3204dea9a2d8100847
https://doi.org/10.1021/acs.joc.7b02503
https://doi.org/10.1021/acs.joc.7b02503
Publikováno v:
Acta Medica Martiniana, Vol 15, Iss 3, Pp 21-29 (2015)
There are many theories that attempt to explain the mechanisms of the effects of inhalation anesthetics - from simpler, pursuing individual effects of anesthetics on the level of the ion channels, to more complex that are looking for uniform global c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17ccb7aa2c228001b5b907dd039c9b23
https://doi.org/10.1515/acm-2015-0014
https://doi.org/10.1515/acm-2015-0014
Autor:
E, Halasova, T, Matakova, M, Skerenova, M, Krutakova, P, Slovakova, A, Dzian, S, Javorkova, M, Pec, K, Kypusova, J, Hamzik
Publikováno v:
Advances in experimental medicine and biology. 911
Chromium is a well-known mutagen and carcinogen involved in lung cancer development. DNA repair genes play an important role in the elimination of genetic changes caused by chromium exposure. In the present study, we investigated the polymorphisms of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::64ecb6e9ef0bb1ed4d340fa753e1b882
https://pubmed.ncbi.nlm.nih.gov/26987333
https://pubmed.ncbi.nlm.nih.gov/26987333
Autor:
M, Krutakova, M, Sarlinova, T, Matakova, A, Dzian, J, Hamzik, M, Pec, S, Javorkova, E, Halasova
Publikováno v:
Advances in experimental medicine and biology. 911
MicroRNAs (miRNAs) are a class of small single-stranded non-protein-coding RNAs that play important regulatory roles in many cellular processes including cell proliferation, differentiation, growth control, and apoptosis. They regulate gene expressio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::89d23d218d8d81f91320e9ad5f7e3a58
https://pubmed.ncbi.nlm.nih.gov/26987328
https://pubmed.ncbi.nlm.nih.gov/26987328
Autor:
Philip J. Hamzik, Jason D. Brubaker
Publikováno v:
Organic Letters. 12:1116-1119
The oxetane ring is useful in drug discovery as a bioisostere for both the geminal dimethyl group and the carbonyl group. A convenient, straightforward approach to access structurally diverse 3-aminooxetanes through the reactivity of oxetan-3-tert-bu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd7695fab3c960ec8608b607bb94cd27
https://doi.org/10.1021/ol100119e
https://doi.org/10.1021/ol100119e
Autor:
Jason D. Brubaker, Philip J. Hamzik
Publikováno v:
ChemInform. 41
The oxetane ring is useful in drug discovery as a bioisostere for both the geminal dimethyl group and the carbonyl group. A convenient, straightforward approach to access structurally diverse 3-aminooxetanes through the reactivity of oxetan-3-tert-bu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::31fb78da011bbd4e3d9831c7bba268a9
https://doi.org/10.1002/chin.201029115
https://doi.org/10.1002/chin.201029115
Publikováno v:
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. 59
The present study was aimed at the assessment of the impact of mother smoking during pregnancy on changes of phase angle (phi) and T(me)/T(E) index in healthy children. A hundred and twenty seven children, divided according to age (6 months and6 mont
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::54f29c87d01d6ff30fda4b7d66d5ce8e
https://pubmed.ncbi.nlm.nih.gov/19218677
https://pubmed.ncbi.nlm.nih.gov/19218677
Autor:
J. Erzen, A.P. Kappetein, G. Gotti, T. Horvat, P. Hostrup, T. Orlowski, V.M.sa Vieira, Gabriel Mihai Marta, A. Petricevic, Richard G. Berrisford, I. Drescik, N. Ilic, G. Maggi, Thomas F. Molnar, Ph. Noirhomme, Semih Halezeroglu, G. Ramos Seisdedos, Tomasz Grodzki, A. Thorpe, L. Kecskes, P. Van Schil, J. Hasse, C. Ahren, P. Goldstraw, T. Laisaar, K. Moghissi, S. Harustiak, Torkel Åberg, A. Csekeö, Jean-Louis Pujol, J. Hamzik, J. Bibicic, H. Toomes, I. Bellenis, G. Magnanelli, Gilbert Massard, Ralph A. Schmid, Walter Weder, Hans-Beat Ris, A. Arsovski, F. Furmanik, Pavel Pafko, Piero Zannini, Walter Klepetko, D. Branscheid, Andrés Varela, Antoon Lerut, J. Dussek, L. Lampl, Federico Venuta, Gonzalo Varela, Ph. Levasseur, Jean-François Velly, M.T. Godinho, S. Bequiri, K. Jeyasingham, J. Salo, William S. Walker, Jean-Marie Wihlm, E.M. van Raemdonck, P. Hartl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::056efe9978339486399e6914b50c3bc7
http://hdl.handle.net/11573/111356
http://hdl.handle.net/11573/111356
