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NIA BEHAVIORAL AND SOCIAL SCIENCE ADVANCES AND PRIORITIES

Autor: J. Haaga, M.A. Bernard

Dr. John Haaga, director of the NIA Division of Behavioral and Social Science Research (BSR), will briefly outline BSR research priorities and recent science advances, many of which involve international collaborations and comparisons.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a539598730637aff7ecadf8fdd4155e
https://europepmc.org/articles/PMC6248501/

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Dose Escalation to 60 Gy in 3 Fractions with Stereotactic Body Radiation Therapy (SBRT) for Poor Surgical Candidates with Localized Renal Cell Carcinoma: Expansion of a Phase I Study

Autor: Bryan Traughber, Y. Liu, Scott M. Welford, J. Haaga, Mitchell Machtay, Robert Abouassaly, V. Gulani, William Grubb, Rodney J. Ellis, L. Ponsky, Y. Zhang, Simon S. Lo

Publikováno v: International Journal of Radiation Oncology*Biology*Physics. 102:e91

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6d76585b25c58d26246a35f111288df6
https://doi.org/10.1016/j.ijrobp.2018.07.360

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The Response of the Portal Vein to an Oral Glucose Load

Autor: S. Minkin, C. Rada, J. Haaga, M. Knelson, R. E. A. Goldberg

Publikováno v: Journal of Clinical Ultrasound. 18:691-695

Changes of total blood flow, velocities, and cross-sectional area in the portal vein before and after oral glucose administration were studied using image-directed Doppler ultrasonography. Portal vein cross-sectional area, flow velocity, and total bl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::52da966cee97c6059663276ccebd7880
https://doi.org/10.1002/jcu.1990.18.9.691

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Sequential tumor biopsies in early phase clinical trials of anticancer agents for pharmacodynamic evaluation

Autor: A, Dowlati, J, Haaga, S C, Remick, T P, Spiro, S L, Gerson, L, Liu, S J, Berger, N A, Berger, J K, Willson

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 7(10)

In the setting of target-based anticancer drug development, it is critical to establish that the observed preclinical activity can be attributed to modulation of the intended target in early phase trials in human subjects. This paradigm of target mod

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fa0fb63943e250e04c733ea454fc3575
https://pubmed.ncbi.nlm.nih.gov/11595684

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Differential degradation rates of inactivated alkyltransferase in blood mononuclear cells and tumors of patients after treatment with O(6)-benzylguanine

Autor: L, Liu, T P, Spiro, X, Qin, S, Majka, J, Haaga, J, Schupp, J K, Willson, S L, Gerson

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 7(8)

O(6)-Alkylguanine-DNA alkyltransferase (AGT) repairs O(6)-alkylating DNA adducts generated by alkylating therapeutic agents. Therefore, AGT activity may be an important marker of tumor and normal tissue sensitivity to chemotherapeutic agents and a pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b6d11db5c718914eb4cfb9ec3adeeca8
https://pubmed.ncbi.nlm.nih.gov/11489807

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Temozolomide: the effect of once- and twice-a-day dosing on tumor tissue levels of the DNA repair protein O(6)-alkylguanine-DNA-alkyltransferase

Autor: T P, Spiro, L, Liu, S, Majka, J, Haaga, J K, Willson, S L, Gerson

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 7(8)

Temozolomide (TMZ) is a methylating agent of the imidotetrazine class, whose cytotoxic product is O(6)-methylguanine DNA adducts, which initiate a futile recycling of the mismatch repair pathway causing DNA strand breaks and apoptotic cell death in m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::87aa107cabdf845e82cbeaf6fa2ec6ee
https://pubmed.ncbi.nlm.nih.gov/11489806

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O6-benzylguanine: a clinical trial establishing the biochemical modulatory dose in tumor tissue for alkyltransferase-directed DNA repair

Autor: T P, Spiro, S L, Gerson, L, Liu, S, Majka, J, Haaga, C L, Hoppel, S T, Ingalls, J M, Pluda, J K, Willson

Publikováno v: Cancer research. 59(10)

Early phase evaluation of anticancer drugs has traditionally used toxicity (usually hematological) rather than efficacy end points to establish appropriate dosing schedules. To establish a biochemical efficacy end point for overcoming alkylguanine DN

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8010eb1ad8a111844d619c60f49d4e11
https://pubmed.ncbi.nlm.nih.gov/10344750

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Twelve-year follow-up of respondents in a sample survey in Peninsular Malaysia

Autor: J, Haaga, J, Davanzo, C, Peterson, N P, Tey

Publikováno v: Asia-Pacific population journal. 9(2)

"This note reports the experience of an attempt to find and re-interview in late 1988 and early 1989, as part of the Second Malaysian Family Life Survey (MFLS-2), the female respondents to the 1976-77 Malaysian Family Life Survey (MFLS-1) and a sampl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4b770fc6c32199681ccb093c1bcdc2c2
https://pubmed.ncbi.nlm.nih.gov/12288227

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The response of the portal vein to an oral glucose load

Autor: R E, Goldberg, C, Rada, M, Knelson, J, Haaga, S, Minkin

Publikováno v: Journal of clinical ultrasound : JCU. 18(9)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::514641040aec277eb8e7fbfedd8a4987
https://pubmed.ncbi.nlm.nih.gov/2174919

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