Zobrazeno 1 - 10
of 566
pro vyhledávání: '"J, HELMAN"'
Comprehensive, authoritative, and up to date, Pizzo and Poplack's Pediatric Oncology, 8th Edition, remains your most trusted source of information on the care and research of children with cancer. This award-winning text is the single most comprehens
Autor:
Danit G. Saks, Beata Bajorek, Vibeke S. Catts, Adam C. Bentvelzen, Jiyang Jiang, Wei Wen, Karen A. Mather, Anbupalam Thalamuthu, Jessie Huang-Lung, Lisa Nivison-Smith, Lyn R. Griffiths, Robert A. Smith, Adrienne Sexton, Paul James, Tharusha Jayasena, Anne Poljak, Gurpreet K. Hansra, Satoshi Hosoki, Ashley Park, Claudia M. Hillenbrand, Peter van Wijngaarden, Russell J. Chander, Sam Humphrey, Rory Chen, Nicole A. Kochan, Tessa J. Helman, Christopher Levi, Amy Brodtmann, Michael J. O'Sullivan, Romesh Markus, Ken Butcher, Mark Parsons, Jason C. Kovacic, Perminder S. Sachdev
Publikováno v:
Cerebral Circulation - Cognition and Behavior, Vol 6, Iss , Pp 100225- (2024)
Introduction: Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) is a rare genetic condition with a broad phenotypic presentation. This study aims to establish the first Australian cohort of individua
Externí odkaz:
https://doaj.org/article/526edede2535460a845731b93a501cc1
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 10 (2023)
Stress is an important risk factor for modern chronic diseases, with distinct influences in males and females. The sex specificity of the mammalian stress response contributes to the sex-dependent development and impacts of coronary artery disease (C
Externí odkaz:
https://doaj.org/article/6dcce0db950249dbbf0d8a7349dc6bea
Autor:
Emad Darvishi, Katherine Slemmons, Zesheng Wan, Sheetal Mitra, Xiaogang Hou, Jean Hugues Parmentier, Yong-Hwee Eddie Loh, Lee J. Helman
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 22, Iss 7, Pp 274-282 (2020)
Fibroblast growth factor receptor 4 (FGFR4) aberrant expression and activity have been linked to the pathogenesis of a variety of cancers including rhabdomyosarcomas (RMS). We found that treatment of alveolar rhabdomyosarcoma (aRMS) cells with Guadec
Externí odkaz:
https://doaj.org/article/e8a5345bdc5d48c5b2b326717e165c49
Autor:
John A. Ligon, R. Taylor Sundby, Mary F. Wedekind, Fernanda I. Arnaldez, Jaydira Del Rivero, Lori Wiener, Ramaprasad Srinivasan, Melissa Spencer, Amanda Carbonell, Haiyan Lei, John Shern, Seth M. Steinberg, William D. Figg, Cody J. Peer, Sara Zimmerman, Josquin Moraly, Xia Xu, Stephen Fox, King Chan, Michael I. Barbato, Thorkell Andresson, Naomi Taylor, Karel Pacak, J. Keith Killian, Eva Dombi, W. Marston Linehan, Markku Miettinen, Richard Piekarz, Lee J. Helman, Paul Meltzer, Brigitte Widemann, John Glod
Publikováno v:
Clinical Cancer Research. 29:341-348
Purpose: Succinate dehydrogenase (dSDH)-deficient tumors, including pheochromocytoma/paraganglioma, hereditary leiomyomatosis and renal cell cancer–associated renal cell carcinoma (HLRCC-RCC), and gastrointestinal stromal tumors (GIST) without KIT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adba6ac0002d53a36292dcf689273726
https://doi.org/10.1158/1078-0432.ccr-22-2168
https://doi.org/10.1158/1078-0432.ccr-22-2168
Autor:
Brigitte C. Widemann, Yao Lu, Denise Reinke, Scott H. Okuno, Christian F. Meyer, Gregory M. Cote, Rashmi Chugh, Mohammed M. Milhem, Angela C. Hirbe, AeRang Kim, Brian Turpin, Joseph G. Pressey, Eva Dombi, Nalini Jayaprakash, Lee J. Helman, Ndidi Onwudiwe, Karen Cichowski, John P. Perentesis
Publikováno v:
Sarcoma, Vol 2019 (2019)
Purpose. There are no known effective medical treatments for refractory MPNST. Inactivation of the NF1 tumor suppressor in MPNST results in upregulation of mTOR (mammalian target of rapamycin) signaling and angiogenesis, which contributes to disease
Externí odkaz:
https://doaj.org/article/401c98540a2a455a8f01beecb09b82fe
Autor:
Patrick J. Grohar, Lee J. Helman, Natasha J. Caplen, Scott E. Martin, Susan M. Kitchen-Goosen, Carleen A. Klumpp-Thomas, Marie Adams, Sergey Dikalov, Ian Beddows, Zachary B. Madaj, Brandon M. Oswald, Elissa A. Boguslawski, Joel H. Everett, Guillermo Flores
Laboratory values
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::501062fa1daa46709fce14f79900fb92
https://doi.org/10.1158/1535-7163.22518997.v1
https://doi.org/10.1158/1535-7163.22518997.v1
Autor:
Lee J. Helman, Ralph J. DeBerardinis, Craig J. Thomas, Matthew B. Boxer, Jason M. Rohde, Christine M. Heske, Damien Y. Duveau, Tracy I. Rosales, Ria Kidner, Arnulfo Mendoza, Sameer H. Issaq
Supplementary Figure S1. PHGDH is highly expressed in Ewing sarcoma cell lines; Supplementary Figure S2. Measurement of PHGDH protein expression. Immunoblot analysis of PHGDH in the specified cell lines expressing lentiviral control shRNA (shControl)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a681c9199fbfb4fe63d72894a4e78e5a
https://doi.org/10.1158/1535-7163.22521393
https://doi.org/10.1158/1535-7163.22521393
Autor:
Patrick J. Grohar, Lee J. Helman, Natasha J. Caplen, Scott E. Martin, Susan M. Kitchen-Goosen, Carleen A. Klumpp-Thomas, Marie Adams, Sergey Dikalov, Ian Beddows, Zachary B. Madaj, Brandon M. Oswald, Elissa A. Boguslawski, Joel H. Everett, Guillermo Flores
There is a need to develop novel approaches to improve the balance between efficacy and toxicity for transcription factor–targeted therapies. In this study, we exploit context-dependent differences in RNA polymerase II processivity as an approach t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4559f9c6213c0d59a323d14e5f5e7acc
https://doi.org/10.1158/1535-7163.c.6542218
https://doi.org/10.1158/1535-7163.c.6542218
Autor:
Lee J. Helman, Ralph J. DeBerardinis, Craig J. Thomas, Matthew B. Boxer, Jason M. Rohde, Christine M. Heske, Damien Y. Duveau, Tracy I. Rosales, Ria Kidner, Arnulfo Mendoza, Sameer H. Issaq
Supplementary Table S1. Evaluation of drug combinations in TC32 and TC71 Ewing sarcoma cells; Supplementary Table S2. Evaluation of drug combinations in EW8 Ewing sarcoma cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b612de2600080070053fb080f2ff2d4
https://doi.org/10.1158/1535-7163.22521390
https://doi.org/10.1158/1535-7163.22521390