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Akademický článek

ABCC6 deficiency is associated with activation of BMP signaling in liver and kidney

Autor: Ana M. Blazquez-Medela, Pierre J. Guihard, Jiayi Yao, Medet Jumabay, Aldons J. Lusis, Kristina I. Boström, Yucheng Yao

Publikováno v: FEBS Open Bio, Vol 5, Iss 1, Pp 257-263 (2015)

Mutations in ABCC6 (ATP‐binding cassette, subfamily C, member 6), an orphan transporter expressed in the liver, are the cause of pseudoxanthoma elasticum. Since ABCC6 was reported to affect matrix Gla protein (MGP), an inhibitor of bone morphogenet

Externí odkaz: https://doaj.org/article/3bd194daa9ff4b87a1a39579a254721b

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Akademický článek

Endothelial-Mesenchymal Transition in Vascular Calcification of Ins2Akita/+ Mice.

Autor: Pierre J Guihard, Jiayi Yao, Ana M Blazquez-Medela, Luisa Iruela-Arispe, Kristina I Boström, Yucheng Yao

Publikováno v: PLoS ONE, Vol 11, Iss 12, p e0167936 (2016)

Endothelial-mesenchymal transition (EndMT) drives endothelium to contribute to normal development and disease processes. Here, we report that EndMTs occur in the diabetic endothelium of Ins2Akita/wt mouse, and show that induction of sex determining r

Externí odkaz: https://doaj.org/article/ce5ad2853d6f45e2a05b7676a07a7dd2

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Shaping Waves of Bone Morphogenetic Protein Inhibition During Vascular Growth

Autor: Kristina I. Boström, Yucheng Yao, Lily Zhang, Medet Jumabay, Pierre J. Guihard, Yina Guo, Alan Garfinkel, Jiayi Yao, Xiuju Wu

Publikováno v: Circ Res

Rationale: The BMPs (bone morphogenetic proteins) are essential morphogens in angiogenesis and vascular development. Disruption of BMP signaling can trigger cardiovascular diseases, such as arteriovenous malformations. Objective: A computational mode

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00d70bf3a4a722b555031aee7bfe21a2
https://doi.org/10.1161/circresaha.120.317439

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Three-dimensional Imaging Coupled with Topological Quantification Uncovers Retinal Vascular Plexuses Undergoing Obliteration

Autor: Tzung K. Hsiai, Pierre J. Guihard, Kristina I. Boström, Lynn K. Gordon, Song Li, Alison Chu, Parinaz Abiri, Varun Gudapati, Jie Zheng, Kyung In Baek, Michel M. Sun, Xili Ding, Yichen Ding, Chih-Chiang Chang, Scott Meyer

Publikováno v: Theranostics, vol 11, iss 3
Theranostics

Introduction: Murine models provide microvascular insights into the 3-D network disarray seen in retinopathy and cardiovascular diseases. Light-sheet fluorescence microscopy (LSFM) has emerged to capture retinal vasculature in 3-D, allowing for asses

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ddd3ddd5a3741a9d8620f9a3c2b74f7
https://resolver.caltech.edu/CaltechAUTHORS:20201216-100504535

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Selective Plane Illumination Microscopy and Computing Reveal Differential Obliteration of Retinal Vascular Plexuses

Autor: Tzung K. Hsiai, Pierre J. Guihard, Yichen Ding, Michel M. Sun, Chih-Chiang Chang, Varun Gudapati, Alison Chu, Scott Meyer, Jie Zheng, Parinaz Abiri, Lynn K. Gordon, Xili Ding, Kyung In Baek, Song Li, Kristina I. Boström

Murine models of visual impairment provide micro-vascular insights into the 3-D network disarray in retinopathy. Current imaging and analysis tend to be confined to the 2-D retinal vasculature. We hereby integrated selective plane illumination imagin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae570e7e3aed5bca37bef2f320f8fbc7
https://doi.org/10.1101/2020.05.06.081463

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Vascular endothelium plays a key role in directing pulmonary epithelial cell differentiation

Autor: Xiuju Wu, Melissa J. Spencer, Medet Jumabay, Pierre J. Guihard, Ana M. Blazquez-Medela, Yucheng Yao, Jiayi Yao, Peter Tontonoz, Kristina I. Boström, Alan M. Fogelman

Publikováno v: The Journal of Cell Biology
The Journal of cell biology, vol 216, iss 10

J. Yao et al. demonstrate that loss of MGP, a BMP inhibitor, causes abnormal hepatic differentiation in lungs. They find that interactions between endothelium and epithelium separate pulmonary from hepatic differentiation during development. Lack of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20e6074f84bc8d5b00bd0846df06fe0e
https://doi.org/10.1083/jcb.201612122

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Combined effects of bone morphogenetic protein 10 and crossveinless-2 on cardiomyocyte differentiation in mouse adipocyte-derived stem cells

Autor: Jiayinaguli Zhumabai, Arman Saparov, Pierre J. Guihard, Luisa Iruela-Arispe, Katharine C Niklason, Mark R. Cubberly, Alan M. Fogelman, Kristina I. Boström, Yucheng Yao, Medet Jumabay, Nurlan Mansurov

Publikováno v: Journal of Cellular Physiology. 233:1812-1822

Bone morphogenetic protein (BMP) 10, a cardiac-restricted BMP family member, is essential in cardiomyogenesis, especially during trabeculation. Crossveinless-2 [CV2, also known as BMP endothelial cell precursor derived regulator (BMPER) ] is a BMP-bi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83749fa1a7aed88b109b40d0528d1569
https://doi.org/10.1002/jcp.25983

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Angiopoietin-2 predicts morbidity in adults with Fontan physiology

Autor: Ludmila Pawlikowska, Pierre J. Guihard, Aditya S. Shirali, Kristina I. Boström, Gentian Lluri, Jamil Aboulhosn, M. Luisa Iruela-Arispe, Helen Kim, Miles Conrad

Publikováno v: Scientific reports, vol 9, iss 1
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-8 (2019)

Morbidity in patients with single-ventricle Fontan circulation is common and includes arrhythmias, edema, and pulmonary arteriovenous malformations (PAVM) among others. We sought to identify biomarkers that may predict such complications. Twenty-five

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7b95bf8a90329c490c520424c5ff3bf
https://escholarship.org/uc/item/957894vd

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