Zobrazeno 1 - 10
of 355
pro vyhledávání: '"J, Grierson"'
Autor:
Claudia S. Bauer, Christopher P. Webster, Allan C. Shaw, Jannigje R. Kok, Lydia M. Castelli, Ya-Hui Lin, Emma F. Smith, Francisco Illanes-Álvarez, Adrian Higginbottom, Pamela J. Shaw, Mimoun Azzouz, Laura Ferraiuolo, Guillaume M. Hautbergue, Andrew J. Grierson, Kurt J. De Vos
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 16 (2022)
Disruption to protein homeostasis caused by lysosomal dysfunction and associated impairment of autophagy is a prominent pathology in amyotrophic lateral sclerosis and frontotemporal dementia (ALS/FTD). The most common genetic cause of ALS/FTD is a G4
Externí odkaz:
https://doaj.org/article/a7f7ea91bf69440699e3334d2a8e3cbe
Autor:
Paweł K. Łysyganicz, Niedharsan Pooranachandran, Xinming Liu, Kathryn I. Adamson, Katarzyna Zielonka, Stone Elworthy, Fredericus J. van Eeden, Andrew J. Grierson, Jarema J. Malicki
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Cilia are evolutionarily highly conserved organelles with important functions in many organs. The extracellular component of the cilium protruding from the plasma membrane comprises an axoneme composed of microtubule doublets, arranged in a 9 + 0 con
Externí odkaz:
https://doaj.org/article/21b982de488b4869aecf37b8f7e0e109
An interaction between synapsin and C9orf72 regulates excitatory synapses and is impaired in ALS/FTD
Autor:
Claudia S. Bauer, Rebecca N. Cohen, Francesca Sironi, Matthew R. Livesey, Thomas H. Gillingwater, J. Robin Highley, Daniel J. Fillingham, Ian Coldicott, Emma F. Smith, Yolanda B. Gibson, Christopher P. Webster, Andrew J. Grierson, Caterina Bendotti, Kurt J. De Vos
Publikováno v:
Bauer, C S, Cohen, R N, Sironi, F, Livesey, M R, Gillingwater, T H, Highley, J R, Fillingham, D J, Coldicott, I, Smith, E F, Gibson, Y B, Webster, C P, Grierson, A J, Bendotti, C & De Vos, K J 2022, ' An interaction between synapsin and C9orf72 regulates excitatory synapses and is impaired in ALS/FTD ', Acta Neuropathologica, vol. 144, pp. 437–464 .
Dysfunction and degeneration of synapses is a common feature of amyotrophic lateral sclerosis and frontotemporal dementia (ALS/FTD). A GGGGCC hexanucleotide repeat expansion in the C9ORF72 gene is the main genetic cause of ALS/FTD (C9ALS/FTD). The re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e62b958cdd3f8be1dbf86bcad7b19440
https://doi.org/10.1007/s00401-022-02470-z
https://doi.org/10.1007/s00401-022-02470-z
Autor:
Larissa Butler, Kathryn I. Adamson, Stuart L. Johnson, Lydia H. Jestice, Christopher J. Price, Dylan Stavish, Niedharsan Pooranachandran, Jarema J. Malicki, Anestis Tsakiridis, Andrew J. Grierson, Ivana Barbaric
Charcot Marie Tooth Disease (CMT) is a group of inherited progressive conditions affecting distal motor and sensory neurons, leading to muscle weakness, pain and loss of sensation in limbs. There are currently no treatments for this debilitating dise
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::147b706e897137d824f66e7cd774f94a
https://doi.org/10.1101/2022.07.05.498819
https://doi.org/10.1101/2022.07.05.498819
Autor:
Laura Ferraiuolo, Noemi Gatto, Andrew J. Grierson, Chloe F. Allen, Richard J. Mead, Yuri Ciervo, Pamela J. Shaw
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 21, Iss, Pp 413-433 (2021)
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative condition for which new therapeutic options are urgently needed. We injected GFP+ adipose-derived stem cells (EGFP-ADSCs) directly into the cerebrospinal fluid (CSF) of transgenic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57359c003f4b582ff31dd68c8abd43f5
http://www.sciencedirect.com/science/article/pii/S2329050121000577
http://www.sciencedirect.com/science/article/pii/S2329050121000577
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 3, Iss C (2016)
Current barriers to the use of adeno-associated virus serotype 9 (AAV9) in clinical trials for treating neurological disorders are its high expression in many off-target tissues such as liver and heart, and lack of cell specificity within the central
Externí odkaz:
https://doaj.org/article/277aebb8e4f840fda98da39b9a8b4cff
Autor:
Eric J. G. Pollitt, Andrew J. Grierson, Christopher J Derrick, Emily S. Noël, Farah Hussein, Ashley Sanchez Sevilla Uruchurtu
Publikováno v:
Development. 148
During early vertebrate heart development, the heart transitions from a linear tube to a complex asymmetric structure, a morphogenetic process that occurs simultaneously with growth of the heart. Cardiac growth during early heart morphogenesis is dri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01c7da5f9727c5357458d65f8b0b6a7f
https://doi.org/10.1242/dev.199691
https://doi.org/10.1242/dev.199691
Autor:
Kurt J. De Vos, Marco Destro, Andrew J. Grierson, Raffaele Marroccella, Emma F. Smith, Victor Alfred, Darren Robinson, Guillaume M. Hautbergue, Luc Bousset, Laurent Brasseur, Allan C. Shaw, Ronald Melki, Stephen J. Ebbens, Christopher P. Webster, Laura Ferraiuolo, Christa G. Walther, Mimoun Azzouz, Lai Mei Wan, Paolo M. Marchi, Lara Marrone
Dipeptide repeat proteins (DPRs) are aggregation-prone polypeptides encoded by the pathogenic G4C2 repeat expansion in the C9orf72 gene, the most common genetic cause of amyotrophic lateral sclerosis and frontotemporal dementia (ALS/FTD). In this stu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a6426a970417041b495e4e719d1d7e1f
https://doi.org/10.1101/2021.10.11.463891
https://doi.org/10.1101/2021.10.11.463891
Autor:
R. Almeida-Magana, J. Grierson, H. Maroof, R. Clow, E. Dineen, T. Al-Hammouri, N. Muirhead, C. Brew-Graves, J. Kelly, G. Shaw
Publikováno v:
European Urology. 81:S503-S504
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4ddfd538ee15c39eab1030d2037faae1
https://doi.org/10.1016/s0302-2838(22)00411-0
https://doi.org/10.1016/s0302-2838(22)00411-0
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e107918 (2014)
The SOD1G93A mouse has been used since 1994 for preclinical testing in amyotrophic lateral sclerosis (ALS). Despite recent genetic advances in our understanding of ALS, transgenic mice expressing mutant SOD1 remain the best available, and most widely
Externí odkaz:
https://doaj.org/article/b709dfb8daa244d18969cc921db5730c