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United States open-label glatiramer acetate extension trial for relapsing multiple sclerosis: MRI and clinical correlates

Autor: S. Duncil, R. Baumhefner, V. Gausche, L. Tvardek, G. Shifroni, E. Cerreta, S. Remo, J. H. Parnell, D. Lefkowitz, S. J. Bird, L. Needham, B. Borowski, M. Shepard, Y. Stark, S. Craig, L. Pardo, T. Vollmer, E. Katz, G. W. Ellison, C Jr Bever, A. C. Tselis, R. Grossman, P. M. Colletti, S. R. Schwid, I. Pinchasi, M. Singh, Staley A. Brod, W. Badger, Andrew D. Goodman, J. B. Guarnaccia, A. Gudusky, H. Panitch, M. A. Burns, J. Tsuruda, Jerry S. Wolinsky, J. W. Rose, D. Lisak, M. Gorbova, C. J. Becker, L. P. Weiner, E. W C Kwok, Dennis L. Kolson, B. Peters, C. Kawai, J. W. Lindsey, N. Carr, I. Vainrub, R. Misnick, K. McCarthy, R. Lewis, M. D. Petrie, J. Flemming, M. Viswanathan, C. Halvorson, K. P. Johnson, P. Turski, G. Sze, O. Khan, B. R. Brooks, D. Ladkani, D. Pfohl, A. Wallace, K. Martin, A. A. Pruitt, Francisco Gonzalez-Scarano, Ponnada A. Narayana, J. Kamholtz, R. Padilla, R. P. Lisak, L. Mannon, S. Kadosh, C. C. Ford, K. Conway, G. Hunter, S. Bhat, S. Jalbut, L. Medina, L. Rosner, L. W. Myers, G. Moore, J. B. Burns, S. Sinha, E. Greinel, J. Garbern, D. A. Shrier, M. Boykins, J. R. Bentson, N. Kachuck, M. Nessaiver

Publikováno v: Multiple Sclerosis. 7:33-41

After the placebo-controlled extension of the pivotal US trial of glatiramer acetate for the treatment of relapsing multiple sclerosis ended, 208 participants entered an open-label, long-term treatment protocol. Magnetic resonance imaging (MRI) was a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a0a63205d214a1f405d85fd63875403c
https://doi.org/10.1191/135245801667520627

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Iron stores and cerebral veins in MS studied by susceptibility weighted imaging

Autor: E M, Haacke, J, Garbern, Y, Miao, C, Habib, M, Liu

Publikováno v: International angiology : a journal of the International Union of Angiology. 29(2)

In this paper, we seek to determine whether the iron deposition as seen by susceptibility weighted imaging (SWI) in the basal ganglia and thalamus of patients with multiple sclerosis is greater than the iron content measured in normal subjects (indiv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::54202e4a19caaae731a230e71b0d4aed
https://pubmed.ncbi.nlm.nih.gov/20351671

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Evidence for neuroaxonal injury in patients with proteolipid gene mutations

Autor: J. Garbern, M. Shy, K. Krajewski, J. Kamholz, G. Hobson, F. Cambi, R. Schiffmann, S. Bonavita, D. F. Moore, K. Freir, B. Choir, N. Patronas, A. Virta, O. Buespflug--Tanguy, G. Tedeschi

Publikováno v: Neurology. 57(10)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c79ec9d74dd856941e9ddd0eb05808c
https://pubmed.ncbi.nlm.nih.gov/11274318

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Sterols in blood of normal and Smith-Lemli-Opitz subjects

Autor: B, Ruan, W K, Wilson, J, Pang, N, Gerst, F D, Pinkerton, J, Tsai, R I, Kelley, F G, Whitby, D M, Milewicz, J, Garbern, G J, Schroepfer

Publikováno v: Journal of lipid research. 42(5)

Smith-Lemli-Opitz syndrome (SLOS) is a hereditary disorder in which a defective gene encoding 7-dehydrocholesterol reductase causes the accumulation of noncholesterol sterols, such as 7- and 8-dehydrocholesterol. Using rigorous analytical methods in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6839319f44fd8b5e07b3652540e12831
https://pubmed.ncbi.nlm.nih.gov/11352988

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Gtx, an oligodendrocyte-specific homeodomain protein, has repressor activity

Autor: R, Awatramani, J, Beesley, H, Yang, H, Jiang, F, Cambi, J, Grinspan, J, Garbern, J, Kamholz

Publikováno v: Journal of neuroscience research. 61(4)

Myelin, a multilamellar membrane structure that facilitates nerve conduction, is synthesized in the central nervous system (CNS) by oligodendrocytes. Gtx, a member of the homeodomain family of transcriptional factors, is a candidate regulator of myel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9bb3f2e0f8cc22beda62eb63a247a55f
https://pubmed.ncbi.nlm.nih.gov/10931524

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Proteolipid protein mRNA stability is regulated by axonal contact in the rodent peripheral nervous system

Autor: H, Jiang, C S, Duchala, R, Awatramani, S, Shumas, L, Carlock, J, Kamholz, J, Garbern, S S, Scherer, M E, Shy, W B, Macklin

Publikováno v: Journal of neurobiology. 44(1)

Proteolipid protein (PLP) and its alternatively spliced isoform, DM20, are the main intrinsic membrane proteins of compact myelin in the CNS. PLP and DM20 are also expressed by Schwann cells, the myelin-forming cells in the PNS, and are necessary for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d375ce9568dc52cfa8e4b6e9e17a24a3
https://pubmed.ncbi.nlm.nih.gov/10880128

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Charcot-Marie-Tooth disease type 1: molecular pathogenesis to gene therapy

Autor: J, Kamholz, D, Menichella, A, Jani, J, Garbern, R A, Lewis, K M, Krajewski, J, Lilien, S S, Scherer, M E, Shy

Publikováno v: Brain : a journal of neurology. 123

Charcot-Marie-Tooth disease type 1 (CMT1) is caused by mutations in the peripheral myelin protein, 22 kDa (PMP22) gene, protein zero (P0) gene, early growth response gene 2 (EGR-2) and connexin-32 gene, which are expressed in Schwann cells, the myeli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9063b4ce69e565bb2ba4631ed0dea03b
https://pubmed.ncbi.nlm.nih.gov/10648431

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