Zobrazeno 1 - 10
of 2 131
pro vyhledávání: '"J, Ganem"'
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Whole-genome doubling (WGD) commonly occurs in many solid tumors. Here the authors use a zebrafish model of melanoma and in vitro models to show that BRAFV600E induces WGD via inhibition of RhoA and cytokinesis failure.
Externí odkaz:
https://doaj.org/article/310e40fe11654702911f7b011c1df3ce
Autor:
Marc A. Vittoria, Nathan Kingston, Kristyna Kotynkova, Eric Xia, Rui Hong, Lee Huang, Shayna McDonald, Andrew Tilston-Lunel, Revati Darp, Joshua D. Campbell, Deborah Lang, Xiaowei Xu, Craig J. Ceol, Xaralabos Varelas, Neil J. Ganem
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Activating mutations of BRAF alone are inadequate to drive melanoma formation. Here the authors show that activation of Hippo signalling by oncogenic BRAF represents an additional safeguard to limit BRAF-dependent human melanocyte growth and melanoma
Externí odkaz:
https://doaj.org/article/f742ba331c9e4c36a7f1fe1c4bdef362
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-19 (2021)
Abstract The cross-sections of deuteron-induced nuclear reactions suitable for ion beam analysis, measured in different laboratories, are often significantly different. In the present work, differential cross-sections of 27Al(d,p) and 27Al(d,α) reac
Externí odkaz:
https://doaj.org/article/9e970419ed294dd99f4d49ee483a51f4
Autor:
Fabrice J. F. Laroche, Sheng Li, Ning Shen, Soo Kyung Hwang, Gina Nguyen, Wenling Yu, Chen Khuan Wong, Ryan J. Quinton, Jason N. Berman, Ching-Ti Liu, Anurag Singh, Neil J. Ganem, Sam Thiagalingam, Hui Feng
Publikováno v:
Cells, Vol 12, Iss 7, p 980 (2023)
Hyperactive sphingosine 1-phosphate (S1P) signaling is associated with a poor prognosis of triple-negative breast cancer (TNBC). Despite recent evidence that links the S1P receptor 1 (S1P1) to TNBC cell survival, its role in TNBC invasion and the und
Externí odkaz:
https://doaj.org/article/70784a97dfd04f60a796970ef8bf43b7
Autor:
Sanghee Lim, Nicole Hermance, Tenny Mudianto, Hatim M. Mustaly, Ian Paolo Morelos Mauricio, Marc A. Vittoria, Ryan J. Quinton, Brian W. Howell, Hauke Cornils, Amity L. Manning, Neil J. Ganem
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Hippo pathway inactivation plays a role in many cancers, although how tumor cells depress signaling is unclear. Here, Lim et al. identify STK25, which activates LATS in a manner distinct from other upstream kinases and is focally deleted from a range
Externí odkaz:
https://doaj.org/article/fb44cfbe9f3a4df592b8189461124a06
Publikováno v:
Radiation Oncology, Vol 13, Iss 1, Pp 1-8 (2018)
Abstract Objectives To propose an easily applicable segmentation method (perPET-RT) for delineation of tumour volume during radiotherapy on interim fluorine 18 fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) in pati
Externí odkaz:
https://doaj.org/article/6f83fbaf3f9c4079a35d57e431e70390
Akademický článek
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Autor:
Ian Vickridge, M. Salimi, H. Rafi-kheiri, J. J. Ganem, O. Kakuee, Emrick Briand, S. F. Masoudi
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-19 (2021)
Scientific Reports
Scientific Reports, Nature Publishing Group, 2021, 11, pp.18036. ⟨10.1038/s41598-021-97372-7⟩
Scientific Reports
Scientific Reports, Nature Publishing Group, 2021, 11, pp.18036. ⟨10.1038/s41598-021-97372-7⟩
The cross-sections of deuteron-induced nuclear reactions suitable for ion beam analysis, measured in different laboratories, are often significantly different. In the present work, differential cross-sections of 27Al(d,p) and 27Al(d,α) reactions wer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74cee24ac258c94cf6908398412d2696
https://doaj.org/article/9e970419ed294dd99f4d49ee483a51f4
https://doaj.org/article/9e970419ed294dd99f4d49ee483a51f4
Autor:
Shawn M. Lyons, Jasbir S. Dalal, Abigail Metzger, Ching-Shyi Wu, Jess Floro, Alexandra Mora-Martin, Rachel Litman Flynn, Anqi Dai, Adam Labadorf, Daniel Cifuentes, Neil J. Ganem
Publikováno v:
Nucleic Acids Research
RNA provides the framework for the assembly of some of the most intricate macromolecular complexes within the cell, including the spliceosome and the mature ribosome. The assembly of these complexes relies on the coordinated association of RNA with h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbae52c58e92fbff3b8b456ef6cfd347
http://europepmc.org/articles/PMC8450105
http://europepmc.org/articles/PMC8450105
Akademický článek
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