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Autor:
Sue Malcolm, J Furth-Lavi, Maria Bitner-Glindzicz, Khalid Hussain, Diana Blaydon, Virpi V. Smith, Albert Aynsley-Green, Peter A. Farndon, Matthew J. Scanlan, RM Shepherd, Peter J. Milla, Keith J. Lindley, Mark J. Dunne, Paul Rutland, Rachel E. O'Brien, Philippa D. Barnes, Xue Zhong Liu, Jane C. Sowden, Karen E. Cosgrove, Benjamin Glaser
Publikováno v:
Nature Genetics. 26:56-60
Usher syndrome type 1 describes the association of profound, congenital sensorineural deafness, vestibular hypofunction and childhood onset retinitis pigmentosa. It is an autosomal recessive condition and is subdivided on the basis of linkage analysi
Publikováno v:
Journal of Cellular Physiology. 176:624-633
We have examined the effects of three structurally distinct antioxidants (N-acetylcysteine [NAC], Trolox C [a water-soluble vitamin E derivative], and nordihydroguaiaretic acid [NGA]) on the expression of the c-fos gene over a 2-hour period. Determin
Autor:
Daniela Dadon, Ayat Hija, Benjamin Glaser, Kevan C. Herold, Rachel Schyr-Ben Haroush, Miri Stolovich-Rain, Tricia R. Bhatti, Oren Ziv, Tehila Kadosh, Sharona Tornovsky-Babeay, Frances M. Ashcroft, Louis H. Philipson, Peter In 'T Veld, Charles A. Stanley, Zvi Granot, Shay Porat, Elhanan Tzipilevich, Mark A. Magnuson, Yuval Dor, J Furth-Lavi, Ann Saada
Publikováno v:
Cell Metabolism; Vol 19
Summaryβ cell failure in type 2 diabetes (T2D) is associated with hyperglycemia, but the mechanisms are not fully understood. Congenital hyperinsulinism caused by glucokinase mutations (GCK-CHI) is associated with β cell replication and apoptosis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e39b18635a1f3e5ac624339a0d52c40
https://hdl.handle.net/20.500.14017/72a36fd2-5503-4f1a-b231-a822b5c6fbc3
https://hdl.handle.net/20.500.14017/72a36fd2-5503-4f1a-b231-a822b5c6fbc3
Autor:
Anna J. Furth, Jason Liggins
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1361:123-130
Several mechanisms have been postulated for the formation of advanced glycation endproducts (AGEs) from glycated proteins; they all feature protein-bound carbonyl intermediates. Using 2,4-dinitrophenylhydrazine (DNPH), we have detected these intermed
Autor:
Jason Liggins, Anna J. Furth
Publikováno v:
Biochemical and Biophysical Research Communications. 219:186-190
After a hyperglycaemic episode, glycated proteins remain in the body until removed by protein turnover. We have shown that in the absence of free sugar, such proteins can crosslink to native proteins, forming mixed dimers. They can also induce native
Autor:
Ayat Hija, Shay Porat, Zvi Granot, Danny Ben-Zvi, Noa Weinberg-Corem, Miri Stolovich-Rain, J Furth-Lavi, Benjamin Glaser, Sharona Tornovsky-Babaey, Daniela Dadon, Yuval Dor, R. Schyr-Ben-Haroush, Oren Ziv
Publikováno v:
Diabetes, Obesity and Metabolism; Vol 14
Recent studies in mice have shown that pancreatic β-cells have a significant potential for regeneration, suggesting that regenerative therapy for diabetes is feasible. Genetic lineage tracing studies indicate that β-cell regeneration is based on th
Publikováno v:
Blood. 1
Publikováno v:
Journal of the National Cancer Institute. 7(3)