Zobrazeno 1 - 10
of 583
pro vyhledávání: '"J, Fornace A"'
Publikováno v:
DNA, Vol 4, Iss 3, Pp 221-238 (2024)
Oxidative stress-mediated biomolecular damage is a characteristic feature of ionizing radiation (IR) injury, leading to genomic instability and chronic health implications. Specifically, a dose- and linear energy transfer (LET)-dependent persistent i
Externí odkaz:
https://doaj.org/article/8a4d9ac376e940bf8cd8ee373c28b016
Autor:
Evan L. Pannkuk, Evagelia C. Laiakis, Guy Garty, Sunil Bansal, Meth M. Jayatilake, Yuewen Tan, Brian Ponnaiya, Xuefeng Wu, Sally A. Amundson, David J. Brenner, Albert J. Fornace
Publikováno v:
ACS Omega, Vol 9, Iss 32, Pp 35182-35196 (2024)
Externí odkaz:
https://doaj.org/article/c9ef3729879e4462a62c22eee403565f
Autor:
Igor Shuryak, Shanaz A. Ghandhi, Evagelia C. Laiakis, Guy Garty, Xuefeng Wu, Brian Ponnaiya, Emma Kosowski, Evan Pannkuk, Salan P. Kaur, Andrew D. Harken, Naresh Deoli, Albert J. Fornace, David J. Brenner, Sally A. Amundson
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract There is a persistent risk of a large-scale malicious or accidental exposure to ionizing radiation that may affect a large number of people. Exposure will consist of both a photon and neutron component, which will vary in magnitude between i
Externí odkaz:
https://doaj.org/article/2d5470e0716145d4af6f52e648b8df37
Autor:
Evan L. Pannkuk, Igor Shuryak, Anika Kot, Lorreta Yun-Tien Lin, Heng-Hong Li, Albert J. Fornace
Publikováno v:
PLoS ONE, Vol 19, Iss 5 (2024)
Externí odkaz:
https://doaj.org/article/be5147c65ccb47ba9a21b6f3d0f8b7a3
Publikováno v:
Current Oncology, Vol 30, Iss 6, Pp 5497-5514 (2023)
Ionizing radiation (IR) dose, dose rate, and linear energy transfer (LET) determine cellular DNA damage quality and quantity. High-LET heavy ions are prevalent in the deep space environment and can deposit a much greater fraction of total energy in a
Externí odkaz:
https://doaj.org/article/b0c29e15add4459cba9fe6389a3d8e22
Autor:
Jonathan P. Jacobs, Maryam Goudarzi, Venu Lagishetty, Dalin Li, Tytus Mak, Maomeng Tong, Paul Ruegger, Talin Haritunians, Carol Landers, Philip Fleshner, Eric Vasiliauskas, Andrew Ippoliti, Gil Melmed, David Shih, Stephan Targan, James Borneman, Albert J. Fornace, Dermot P. B. McGovern, Jonathan Braun
Publikováno v:
Genome Medicine, Vol 14, Iss 1, Pp 1-20 (2022)
Abstract Background Crohn’s disease (CD) patients demonstrate distinct intestinal microbial compositions and metabolic characteristics compared to unaffected controls. However, the impact of inflammation and underlying genetic risk on these microbi
Externí odkaz:
https://doaj.org/article/fe92c4592aad437cb5c862f197cb01d1
Autor:
Julie K. Buick, Andrea Rowan-Carroll, Rémi Gagné, Andrew Williams, Renxiang Chen, Heng-Hong Li, Albert J. Fornace, Christy Chao, Bevin P. Engelward, Roland Frötschl, Heidrun Ellinger-Ziegelbauer, Syril D. Pettit, Jiri Aubrecht, Carole L. Yauk
Publikováno v:
Frontiers in Toxicology, Vol 4 (2022)
Genotoxicity testing relies on the detection of gene mutations and chromosome damage and has been used in the genetic safety assessment of drugs and chemicals for decades. However, the results of standard genotoxicity tests are often difficult to int
Externí odkaz:
https://doaj.org/article/e639082783d548ec8aa9253661029295
Autor:
Evan L. Pannkuk, Nicole A. S.-Y. Dorville, Yvonne A. Dzal, Quinn E. Fletcher, Kaleigh J. O. Norquay, Craig K. R. Willis, Albert J. Fornace, Evagelia C. Laiakis
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract White-nose syndrome (WNS) is an emergent wildlife fungal disease of cave-dwelling, hibernating bats that has led to unprecedented mortalities throughout North America. A primary factor in WNS-associated bat mortality includes increased arous
Externí odkaz:
https://doaj.org/article/1f62c6b0986043c9945781a710ef9352
Publikováno v:
PLoS ONE, Vol 17, Iss 12, p e0279771 (2022)
Space radiation-induced gastrointestinal (GI) cancer risk models for future interplanetary astronauts are being developed that primarily rely on quantitative animal model studies to assess radiation-quality effects of heavy-ion space radiation exposu
Externí odkaz:
https://doaj.org/article/3637e374c8da45898a3dad39ffe26dbf
Publikováno v:
Heliyon, Vol 8, Iss 1, Pp e08691- (2022)
Low-LET photon radiation-induced persistent alterations in bone marrow (BM) cells are well documented in total-body irradiated (TBI) rodents and also among radiotherapy patients. However, the late effects of protons and high-LET heavy-ion radiation o
Externí odkaz:
https://doaj.org/article/004cbdc9e8b14df5907550fc4216339f