Zobrazeno 1 - 10
of 3 604
pro vyhledávání: '"J, Fitzpatrick"'
Autor:
E. Sethe Burgie, Katherine Basore, Michael J. Rau, Brock Summers, Alayna J. Mickles, Vadim Grigura, James A. J. Fitzpatrick, Richard D. Vierstra
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Phytochromes (Phys) are a divergent cohort of bili-proteins that detect light through reversible interconversion between dark-adapted Pr and photoactivated Pfr states. While our understandings of downstream events are emerging, it remains un
Externí odkaz:
https://doaj.org/article/5e15d9f98a49457186b4cb356d9007e0
Autor:
Roshan Sivakumar, Katherine Floyd, Jessey Erath, Alex Jacoby, Jenny Kim Kim, Peter O. Bayguinov, James A. J. Fitzpatrick, Dennis Goldfarb, Marko Jovanovic, Abhai Tripathi, Sergej Djuranovic, Slavica Pavlovic-Djuranovic
Publikováno v:
Malaria Journal, Vol 23, Iss 1, Pp 1-18 (2024)
Abstract Background Plasmodium falciparum, the malaria-causing parasite, is a leading cause of infection-induced deaths worldwide. The preferred treatment approach is artemisinin-based combination therapy, which couples fast-acting artemisinin deriva
Externí odkaz:
https://doaj.org/article/2d249f61461a4b818c93e42e4c485a6e
Autor:
Dhruva D. Dhavale, Alexander M. Barclay, Collin G. Borcik, Katherine Basore, Deborah A. Berthold, Isabelle R. Gordon, Jialu Liu, Moses H. Milchberg, Jennifer Y. O’Shea, Michael J. Rau, Zachary Smith, Soumyo Sen, Brock Summers, John Smith, Owen A. Warmuth, Richard J. Perrin, Joel S. Perlmutter, Qian Chen, James A. J. Fitzpatrick, Charles D. Schwieters, Emad Tajkhorshid, Chad M. Rienstra, Paul T. Kotzbauer
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract The defining feature of Parkinson disease (PD) and Lewy body dementia (LBD) is the accumulation of alpha-synuclein (Asyn) fibrils in Lewy bodies and Lewy neurites. Here we develop and validate a method to amplify Asyn fibrils extracted from
Externí odkaz:
https://doaj.org/article/34678621ec164ec7a36f533a9c6f2b2a
Autor:
Aura R. Garrison, Vanessa Moresco, Xiankun Zeng, Curtis R. Cline, Michael D. Ward, Keersten M. Ricks, Scott P. Olschner, Lisa H. Cazares, Elif Karaaslan, Collin J. Fitzpatrick, Éric Bergeron, Scott D. Pegan, Joseph W. Golden
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Crimean-Congo hemorrhagic fever virus (CCHFV) is a WHO priority pathogen. Antibody-based medical countermeasures offer an important strategy to mitigate severe disease caused by CCHFV. Most efforts have focused on targeting the viral glycopr
Externí odkaz:
https://doaj.org/article/a3c8734482f549baaa8a2f4d86fd797e
Autor:
Vikram Dalal, Mark J. Arcario, John T. Petroff, Brandon K. Tan, Noah M. Dietzen, Michael J. Rau, James A. J. Fitzpatrick, Grace Brannigan, Wayland W. L. Cheng
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)
Abstract Lipid nanodiscs have become a standard tool for studying membrane proteins, including using single particle cryo-electron microscopy (cryo-EM). We find that reconstituting the pentameric ligand-gated ion channel (pLGIC), Erwinia ligand-gated
Externí odkaz:
https://doaj.org/article/bb81c76ea0364e6bbfdacc3892a310a3
Autor:
Jaigeeth Deveryshetty, Rahul Chadda, Jenna R. Mattice, Simrithaa Karunakaran, Michael J. Rau, Katherine Basore, Nilisha Pokhrel, Noah Englander, James A. J. Fitzpatrick, Brian Bothner, Edwin Antony
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Homologous recombination (HR) is an essential double-stranded DNA break repair pathway. In HR, Rad52 facilitates the formation of Rad51 nucleoprotein filaments on RPA-coated ssDNA. Here, we decipher how Rad52 functions using single-particle
Externí odkaz:
https://doaj.org/article/01f000207b0349d299eef6c4244d2fbc
NewYork-Presbyterian Hospital, one of the nation's most comprehensive academic healthcare delivery systems, uses the evidence-based practice PEACE model to prepare all its nurses and position them as essential to improving patient and family-centered
Autor:
Scott J. Fitzpatrick, Heather Lamb, Erin Stewart, Amelia Gulliver, Alyssa R. Morse, Melanie Giugni, Michelle Banfield
Publikováno v:
Health Expectations, Vol 26, Iss 4, Pp 1738-1745 (2023)
Abstract Introduction Numerous frameworks for defining and supporting co‐created research exist. The practicalities of designing and conducting co‐created research are clearly important, yet the utility of these frameworks and their operationalis
Externí odkaz:
https://doaj.org/article/9932f94583a04881aee701972313cb83
Publikováno v:
Physical Review Research, Vol 6, Iss 1, p L012020 (2024)
Precisely synthesized driving fields for relativistic laser-plasma interactions are shown, using particle in cell simulations, to allow for the absolute control over the temporal structure, and efficiency, of emitted attosecond pulse trains. Using a
Externí odkaz:
https://doaj.org/article/1a2e588393c240b6aa11937273d1e29b
Publikováno v:
Koedoe: African Protected Area Conservation and Science, Vol 65, Iss 1, Pp e1-e7 (2023)
In order to contribute to spider diversity distribution records within Zimbabwe, spiders were sampled at a mixed wildlife and cattle ranch using pitfall traps and sweep-netting. Sampling was conducted from June 2017 to April 2018. A total of 2328 spi
Externí odkaz:
https://doaj.org/article/ec1e1a41fcbd460a8fccfe7e2d0c3824