Zobrazeno 1 - 10
of 897
pro vyhledávání: '"J, Fell"'
Autor:
Noah Lubben, Julia K. Brynildsen, Connor M. Webb, Howard L. Li, Cheryl E. G. Leyns, Lakshmi Changolkar, Bin Zhang, Emily S. Meymand, Mia O’Reilly, Zach Madaj, Daniella DeWeerd, Matthew J. Fell, Virginia M. Y. Lee, Dani S. Bassett, Michael X. Henderson
Publikováno v:
Translational Neurodegeneration, Vol 13, Iss 1, Pp 1-20 (2024)
Abstract Background Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common cause of familial Parkinson’s disease (PD). These mutations elevate the LRRK2 kinase activity, making LRRK2 kinase inhibitors an attractive therapeutic. LRRK2
Externí odkaz:
https://doaj.org/article/1f84f0e37fc14d51a4c531d8dca9e20e
Autor:
Cheryl E. G. Leyns, Alice Prigent, Brenna Beezhold, Lihang Yao, Nathan G. Hatcher, Peining Tao, John Kang, EunRan Suh, Vivianna M. Van Deerlin, John Q. Trojanowski, Virginia M. Y. Lee, Matthew E. Kennedy, Matthew J. Fell, Michael X. Henderson
Publikováno v:
npj Parkinson's Disease, Vol 9, Iss 1, Pp 1-14 (2023)
Abstract Parkinson’s disease (PD) and dementia with Lewy bodies (DLB) are progressive neurodegenerative diseases characterized by the accumulation of misfolded α-synuclein in the form of Lewy pathology. While most cases are sporadic, there are rar
Externí odkaz:
https://doaj.org/article/ffdac8823595475f8729dc4c771b2777
Autor:
Richard M. Gunner, Mark D. Holton, David M. Scantlebury, Phil Hopkins, Emily L. C. Shepard, Adam J. Fell, Baptiste Garde, Flavio Quintana, Agustina Gómez-Laich, Ken Yoda, Takashi Yamamoto, Holly English, Sam Ferreira, Danny Govender, Pauli Viljoen, Angela Bruns, O. Louis van Schalkwyk, Nik C. Cole, Vikash Tatayah, Luca Börger, James Redcliffe, Stephen H. Bell, Nikki J. Marks, Nigel C. Bennett, Mariano H. Tonini, Hannah J. Williams, Carlos M. Duarte, Martin C. van Rooyen, Mads F. Bertelsen, Craig J. Tambling, Rory P. Wilson
Publikováno v:
Animal Biotelemetry, Vol 9, Iss 1, Pp 1-22 (2021)
Abstract Background Understanding what animals do in time and space is important for a range of ecological questions, however accurate estimates of how animals use space is challenging. Within the use of animal-attached tags, radio telemetry (includi
Externí odkaz:
https://doaj.org/article/59ec8e5e88d84e46ad3829b8c2c01dc1
Autor:
Michael J. Fell
Publikováno v:
Cleaner and Responsible Consumption, Vol 2, Iss , Pp 100013- (2021)
Peer-to-peer (P2P) energy trading – where energy prosumers transact directly between each other – could help enable transition to a low-carbon energy system. If it is to be supported in policy and regulation, it is important to anticipate the dis
Externí odkaz:
https://doaj.org/article/89fd4ed9a87f4f19aa8a85774d3434d6
Publikováno v:
Buildings & Cities, Vol 2, Iss 1 (2021)
Energy use is of crucial importance for the global challenge of climate change, and also is an essential part of daily life. Hence, research on energy needs to be robust and valid. Other scientific disciplines have experienced a reproducibility crisi
Externí odkaz:
https://doaj.org/article/8ba1aa675b8d44cf80a1c1e639ac84cb
Autor:
M. Derner, G. Dehnen, L. Chaieb, T.P. Reber, V. Borger, R. Surges, B.P. Staresina, F. Mormann, J. Fell
Publikováno v:
NeuroImage, Vol 221, Iss , Pp 117214- (2020)
Electrophysiological activity in medial temporal lobe (MTL) structures is pivotal for declarative long-term memory. Single-neuron and microcircuit findings capitalizing on human microwire recordings from the medial temporal lobe are still fragmentary
Externí odkaz:
https://doaj.org/article/1ea38a6bd04c4eccb75ec31ba9c4e5ca
Autor:
David A. Candito, Vladimir Simov, Anmol Gulati, Solomon Kattar, Ryan W. Chau, Blair T. Lapointe, Joey L. Methot, Duane E. DeMong, Thomas H. Graham, Ravi Kurukulasuriya, Mitchell H. Keylor, Ling Tong, Gregori J. Morriello, John J. Acton, Barbara Pio, Weiguo Liu, Jack D. Scott, Michael J. Ardolino, Theodore A. Martinot, Matthew L. Maddess, Xin Yan, Hakan Gunaydin, Rachel L. Palte, Spencer E. McMinn, Lisa Nogle, Hongshi Yu, Ellen C. Minnihan, Charles A. Lesburg, Ping Liu, Jing Su, Laxminarayan G. Hegde, Lily Y. Moy, Janice D. Woodhouse, Robert Faltus, Tina Xiong, Paul Ciaccio, Jennifer A. Piesvaux, Karin M. Otte, Matthew E. Kennedy, David Jonathan Bennett, Erin F. DiMauro, Matthew J. Fell, Santhosh Neelamkavil, Harold B. Wood, Peter H. Fuller, J. Michael Ellis
Publikováno v:
Journal of Medicinal Chemistry. 65:16801-16817
Autor:
Hardy J. Rideout, Marie-Christine Chartier-Harlin, Matthew J. Fell, Warren D. Hirst, Sarah Huntwork-Rodriguez, Cheryl E. G. Leyns, Omar S. Mabrouk, Jean-Marc Taymans
Publikováno v:
Frontiers in Neuroscience, Vol 14 (2020)
Evidence is mounting that LRRK2 function, particularly its kinase activity, is elevated in multiple forms of Parkinson’s disease, both idiopathic as well as familial forms linked to mutations in the LRRK2 gene. However, sensitive quantitative marke
Externí odkaz:
https://doaj.org/article/9b99a1e11ad44ba693fc6e89a5f08950
Autor:
Alexandra Beilina, Luis Bonet-Ponce, Ravindran Kumaran, Jennifer J. Kordich, Morié Ishida, Adamantios Mamais, Alice Kaganovich, Sara Saez-Atienzar, David C. Gershlick, Dorien A. Roosen, Laura Pellegrini, Vlad Malkov, Matthew J. Fell, Kirsten Harvey, Juan S. Bonifacino, Darren J. Moore, Mark R. Cookson
Publikováno v:
Cell Reports, Vol 31, Iss 5, Pp - (2020)
Summary: Mutations in Leucine-rich repeat kinase 2 (LRRK2) cause Parkinson’s disease (PD). However, the precise function of LRRK2 remains unclear. We report an interaction between LRRK2 and VPS52, a subunit of the Golgi-associated retrograde protei
Externí odkaz:
https://doaj.org/article/8f3645a2b68b47bab2889e3c6b78354d
Autor:
Lindsey M. Crown, Mitchell J. Bartlett, Jean-Paul L. Wiegand, Allison J. Eby, Emily J. Monroe, Kathleen Gies, Luke Wohlford, Matthew J. Fell, Torsten Falk, Stephen L. Cowen
Publikováno v:
Frontiers in Neurology, Vol 11 (2020)
Sleep disturbances co-occur with and precede the onset of motor symptoms in Parkinson's disease (PD). We evaluated sleep fragmentation and thalamocortical sleep spindles in mice expressing the p.G2019S mutation of the leucine-rich repeat kinase 2 (LR
Externí odkaz:
https://doaj.org/article/9a9f3bac1f204f1b8953da46c419f8bd