Zobrazeno 1 - 10
of 1 842
pro vyhledávání: '"J, FAURE"'
Autor:
Andre J. Faure, Ben Lehner
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-26 (2024)
Abstract We present MoCHI, a tool to fit interpretable models using deep mutational scanning data. MoCHI infers free energy changes, as well as interaction terms (energetic couplings) for specified biophysical models, including from multimodal phenot
Externí odkaz:
https://doaj.org/article/2fa79b0b87d44dd4ba3f6222a5e82f13
Autor:
Alexandra M. Bendel, Andre J. Faure, Dominique Klein, Kenji Shimada, Romane Lyautey, Nicole Schiffelholz, Georg Kempf, Simone Cavadini, Ben Lehner, Guillaume Diss
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract The encoding and evolution of specificity and affinity in protein-protein interactions is poorly understood. Here, we address this question by quantifying how all mutations in one protein, JUN, alter binding to all other members of a protein
Externí odkaz:
https://doaj.org/article/94b0ef1f5243491094d86a12969bca01
Autor:
J. Monzac, S. Smartsev, J. Huijts, L. Rovige, I. A. Andriyash, A. Vernier, V. Tomkus, V. Girdauskas, G. Raciukaitis, M. Mackevičiūtė, V. Stankevic, A. Cavagna, J. Kaur, A. Kalouguine, R. Lopez-Martens, J. Faure
Publikováno v:
Physical Review Research, Vol 6, Iss 4, p 043099 (2024)
We present significant advances in laser wakefield acceleration (LWFA) operating at a 1 kHz repetition rate, employing a sub-TW, few-femtosecond laser and a continuously flowing hydrogen gas target. We conducted a comprehensive study assessing how th
Externí odkaz:
https://doaj.org/article/1e71899621cf4301bf08ef95e209d988
Publikováno v:
Geoscientific Model Development, Vol 16, Pp 7339-7355 (2023)
A key challenge in paleoseismology is constraining the timing and occurrence of past earthquakes to create an earthquake history along faults that can be used for testing or building fault-based seismic hazard assessments. We present a new methodolog
Externí odkaz:
https://doaj.org/article/a3adc0e9a9414c9cb0eb2f829967c70d
Autor:
Meschis, M., Roberts, G.P., Robertson, J., Mildon, Z.K., Sahy, D., Goswami, R., Sgambato, C., Walker, J. Faure, Michetti, A.M., Iezzi, F.
Publikováno v:
In Geomorphology 1 November 2022 416
Publikováno v:
Genome Biology, Vol 21, Iss 1, Pp 1-23 (2020)
Abstract Deep mutational scanning (DMS) enables multiplexed measurement of the effects of thousands of variants of proteins, RNAs, and regulatory elements. Here, we present a customizable pipeline, DiMSum, that represents an end-to-end solution for o
Externí odkaz:
https://doaj.org/article/00c2de803bfe4d1cb9a45d70315f62d2
Autor:
I. Gonzalez-Vallejo, V. L. R. Jacques, D. Boschetto, G. Rizza, A. Hadj-Azzem, J. Faure, D. Le Bolloc'h
Publikováno v:
Structural Dynamics, Vol 9, Iss 1, Pp 014502-014502-9 (2022)
We use ultrafast electron diffraction to study the out-of-equilibrium dynamics of the charge density wave (CDW) phase transition in GdTe3, a quasi-two-dimensional compound displaying a unidirectional CDW state. Experiments were conducted at different
Externí odkaz:
https://doaj.org/article/5799e00da5444d24bf9c4ea542a5e8c6
Autor:
Benedetta Bolognesi, Andre J. Faure, Mireia Seuma, Jörn M. Schmiedel, Gian Gaetano Tartaglia, Ben Lehner
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
TDP43 aggregates are a hallmark of amyotrophic lateral sclerosis. By using deep mutagenesis to measure the toxicity of more than 50,000 mutations in the prion domain of TDP43, the authors conclude that mutations that increase toxicity promote formati
Externí odkaz:
https://doaj.org/article/0fca2a044c88458bacfb8b409c6af5b7
Publikováno v:
PLoS Genetics, Vol 17, Iss 2, p e1009353 (2021)
RNA structures are dynamic. As a consequence, mutational effects can be hard to rationalize with reference to a single static native structure. We reasoned that deep mutational scanning experiments, which couple molecular function to fitness, should
Externí odkaz:
https://doaj.org/article/d33c6671e55f46499cd5307506c2944d
Publikováno v:
eLife, Vol 10 (2021)
Plaques of the amyloid beta (Aß) peptide are a pathological hallmark of Alzheimer’s disease (AD), the most common form of dementia. Mutations in Aß also cause familial forms of AD (fAD). Here, we use deep mutational scanning to quantify the effec
Externí odkaz:
https://doaj.org/article/70aa61e788c243829de236a89dae4fc6