Výsledky vyhledávání - "J, Engelhardt"

Akademický článek

Impact of protocol‐based physiotherapy on insulin sensitivity and peripheral glucose metabolism in critically ill patients

Autor: Niklas M. Carbon, Lilian J. Engelhardt, Tobias Wollersheim, Julius J. Grunow, Claudia D. Spies, Sven Märdian, Knut Mai, Joachim Spranger, Steffen Weber‐Carstens

Publikováno v: Journal of Cachexia, Sarcopenia and Muscle, Vol 13, Iss 2, Pp 1045-1053 (2022)

Abstract Background The impact of physiotherapy on insulin sensitivity and peripheral glucose metabolism in critically ill patients is not well understood. Methods This pooled analysis investigates the impact of different physiotherapeutic strategies

Externí odkaz: https://doaj.org/article/9be3cbebb51d46b3944c69fb725f3346

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Akademický článek

High‐diversity seed additions promote herb‐layer recovery during restoration of degraded oak woodland

Autor: Andrew D. Kaul, Noah D. Dell, Bradley M. Delfeld, Megan J. Engelhardt, Quinn G. Long, J. Leighton Reid, Michael L. Saxton, James C. Trager, Matthew A. Albrecht

Publikováno v: Ecological Solutions and Evidence, Vol 4, Iss 1, Pp n/a-n/a (2023)

Abstract Seed limitation represents a fundamental constraint to the restoration of native plant communities, and practitioners often apply seed additions to overcome this barrier. However, surprisingly few studies have experimentally tested whether s

Externí odkaz: https://doaj.org/article/dd8bde2c70f0430e87de8813f556b500

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Akademický článek

Neuromodulation of temporal prediction using tACS

Autor: Rebecca Burke, Jonas Misselhorn, Felix J. Engelhardt, Till R. Schneider, Andreas K. Engel

Publikováno v: Brain Stimulation, Vol 16, Iss 1, Pp 393- (2023)

Externí odkaz: https://doaj.org/article/d0fc2b10722242d0a37d16361a43afc7

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Akademický článek

Improved therapeutic index of an acidic pH-selective antibody

Autor: Peter S. Lee, Katherine G. MacDonald, Evan Massi, Pamela V. Chew, Christine Bee, Padma Perkins, Bryant Chau, Kent Thudium, Jack Lohre, Pradyot Nandi, Ekaterina G. Deyanova, Ishita Barman, Olafur Gudmundsson, Gavin Dollinger, Tim Sproul, John J. Engelhardt, Pavel Strop, Arvind Rajpal

Publikováno v: mAbs, Vol 14, Iss 1 (2022)

Although therapeutically efficacious, ipilimumab can exhibit dose-limiting toxicity that prevents maximal efficacious clinical outcomes and can lead to discontinuation of treatment. We hypothesized that an acidic pH-selective ipilimumab (pH Ipi), whi

Externí odkaz: https://doaj.org/article/691eb159503a4399a519acfc7748ae85

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Supplementary Figure Legend from Anti-CTLA-4 Antibodies of IgG2a Isotype Enhance Antitumor Activity through Reduction of Intratumoral Regulatory T Cells

Autor: Alan J. Korman, Mohan Srinivasan, Timothy Chen, Karla A. Henning, Michael Quigley, John J. Engelhardt, Mark J. Selby

PDF file - 102K

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a78834acb42bbd09b0c532e9cc23c8a
https://doi.org/10.1158/2326-6066.22536218.v1

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Supplementary Figures 1 - 4 from Anti-CTLA-4 Antibodies of IgG2a Isotype Enhance Antitumor Activity through Reduction of Intratumoral Regulatory T Cells

Autor: Alan J. Korman, Mohan Srinivasan, Timothy Chen, Karla A. Henning, Michael Quigley, John J. Engelhardt, Mark J. Selby

PDF file - 206K, Supplemental Figure S1. Equivalent binding of anti-CTLA-4 isotypes to cell surface CTLA-4. Supplemental Figure S2. Serum concentrations of anti-CTLA-4 isotypes in C57BL/6 mice. Supplemental Figure S3. Representative FACS plots for pe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2f18a019212133139aeaed992d67891
https://doi.org/10.1158/2326-6066.22536215

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Data from Anti-CTLA-4 Antibodies of IgG2a Isotype Enhance Antitumor Activity through Reduction of Intratumoral Regulatory T Cells

Autor: Alan J. Korman, Mohan Srinivasan, Timothy Chen, Karla A. Henning, Michael Quigley, John J. Engelhardt, Mark J. Selby

Antitumor activity of CTLA-4 antibody blockade is thought to be mediated by interfering with the negative regulation of T-effector cell (Teff) function resulting from CTLA-4 engagement by B7-ligands. In addition, a role for CTLA-4 on regulatory T cel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6011009163f523d370deaf09ace35c72
https://doi.org/10.1158/2326-6066.c.6548072

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Supplementary Tables 1 - 2 from Anti-CTLA-4 Antibodies of IgG2a Isotype Enhance Antitumor Activity through Reduction of Intratumoral Regulatory T Cells

Autor: Alan J. Korman, Mohan Srinivasan, Timothy Chen, Karla A. Henning, Michael Quigley, John J. Engelhardt, Mark J. Selby

PDF file - 94K, Supplemental Table S1. Binding affinities of anti-CTLA-4 isotypes to murine FcγR proteins as assessed by surface plasmon resonance. Supplemental Table S2. Summary of pharmacokinetic parameters of anti-CTLA4 isotypes following a singl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9402efd30c653fdbc8ddf8b449235fcc
https://doi.org/10.1158/2326-6066.22536212.v1

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Akademický článek

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