Zobrazeno 1 - 10
of 784
pro vyhledávání: '"J, Eck"'
Autor:
Zhengnian Li, Jie Jiang, Scott B. Ficarro, Tyler S. Beyett, Ciric To, Isidoro Tavares, Yingde Zhu, Jiaqi Li, Michael J. Eck, Pasi A. Jänne, Jarrod A. Marto, Tinghu Zhang, Jianwei Che, Nathanael S. Gray
Publikováno v:
ACS Central Science, Vol 10, Iss 6, Pp 1156-1166 (2024)
Externí odkaz:
https://doaj.org/article/d5c6dbf338584d8bbd4b0121b594a89f
Autor:
Florian Wittlinger, Blessing C. Ogboo, Ekaterina Shevchenko, Tahereh Damghani, Calvin D. Pham, Ilse K. Schaeffner, Brandon T. Oligny, Surbhi P. Chitnis, Tyler S. Beyett, Alexander Rasch, Brian Buckley, Daniel A. Urul, Tatiana Shaurova, Earl W. May, Erik M. Schaefer, Michael J. Eck, Pamela A. Hershberger, Antti Poso, Stefan A. Laufer, David E. Heppner
Publikováno v:
Communications Chemistry, Vol 7, Iss 1, Pp 1-14 (2024)
Abstract Bivalent molecules consisting of groups connected through bridging linkers often exhibit strong target binding and unique biological effects. However, developing bivalent inhibitors with the desired activity is challenging due to the dual mo
Externí odkaz:
https://doaj.org/article/4d98b317db4743c79540cdb1697614f4
Autor:
Vaishnavi S. Jadhav, Jade G. Stair, Randall J. Eck, Samuel N. Smukowski, Heather N. Currey, Laura Garcia Toscano, Joshua C. Hincks, Caitlin S. Latimer, Paul N. Valdmanis, Brian C. Kraemer, Nicole F. Liachko
Publikováno v:
Neurobiology of Disease, Vol 193, Iss , Pp 106441- (2024)
Alzheimer's disease (AD), the most common aging-associated neurodegenerative dementia disorder, is defined by the presence of amyloid beta (Aβ) and tau aggregates in the brain. However, more than half of patients also exhibit aggregates of the prote
Externí odkaz:
https://doaj.org/article/2d36b23e4d484bf4a6f3f2d1918e850e
Publikováno v:
Advancements in Agricultural Development, Vol 5, Iss 1 (2024)
Effective teaching is complex as it encapsulates professional, interpersonal, and intrapersonal knowledge. Professionalism is often tied to dispositions, although ambiguous definitions and cultural sensitivity make it a difficult task. Therefore, thi
Externí odkaz:
https://doaj.org/article/2414ab16400a4cabad48bfe07b738224
Autor:
Christopher J. Eck, Kevin Wagner
Publikováno v:
Advancements in Agricultural Development, Vol 5, Iss 1 (2024)
Adolescents’ (i.e., high school students) opinions and preferences are important and less likely to be influenced by political and social norms, especially considering natural resource and climate related issues. Therefore, this study sought to ide
Externí odkaz:
https://doaj.org/article/1eb10a94f23a4f4191dab8f98c61fed7
Autor:
Eunyoung Park, Shaun Rawson, Anna Schmoker, Byeong-Won Kim, Sehee Oh, Kangkang Song, Hyesung Jeon, Michael J. Eck
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract RAF-family kinases are activated by recruitment to the plasma membrane by GTP-bound RAS, whereupon they initiate signaling through the MAP kinase cascade. Prior structural studies of KRAS with RAF have focused on the isolated RAS-binding and
Externí odkaz:
https://doaj.org/article/024f9e85bb9c4c38ad6050e31be70692
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2024)
The nematode Caenorhabditis elegans are a powerful model system to study human disease, with numerous experimental advantages including significant genetic and cellular homology to vertebrate animals, a short lifespan, and tractable behavioral, molec
Externí odkaz:
https://doaj.org/article/b2c4b137fffb423cbccbd3de9ef9b2a5
Publikováno v:
Advancements in Agricultural Development, Vol 4, Iss 3 (2023)
The school-based agricultural education (SBAE) teacher attrition crisis dates back to the passing of the Smith-Hughes Act in 1917. For the past three decades, researchers have studied this phenomenon to better understand the needs of SBAE teachers in
Externí odkaz:
https://doaj.org/article/3a38b07d05e54209be2b395d2f4d1f7c
Autor:
R. J. Eck, J. J. C. M. van de Leur, R. Wiersema, E. G. M. Cox, W. Bult, A. J. Spanjersberg, I. C. C. van der Horst, M. V. Lukens, R. O. B. Gans, K. Meijer, F. Keus
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-9 (2022)
Abstract Our objective was to assess the incidence of drug bioaccumulation in critically ill COVID-19 patients with AKI receiving intermediate dose nadroparin for thrombosis prophylaxis. We conducted a Prospective cohort study of critically ill COVID
Externí odkaz:
https://doaj.org/article/36d5a44e8d34446fae6d52280adc1823
Autor:
Tyler S. Beyett, Ciric To, David E. Heppner, Jaimin K. Rana, Anna M. Schmoker, Jaebong Jang, Dries J. H. De Clercq, Gabriel Gomez, David A. Scott, Nathanael S. Gray, Pasi A. Jänne, Michael J. Eck
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Acquired drug resistance is common during chemotherapy. Here, the authors describe the structural basis and molecular mechanism by which allosteric and clinically approved, ATP-competitive inhibitors of EGFR synergize to overcome resistance in lung c
Externí odkaz:
https://doaj.org/article/b71e888015d54f3e90272f29edf5c334