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Akademický článek

Banff Digital Pathology Working Group: Image Bank, Artificial Intelligence Algorithm, and Challenge Trial Developments

Publikováno v: Transplant International, Vol 36 (2023)

The Banff Digital Pathology Working Group (DPWG) was established with the goal to establish a digital pathology repository; develop, validate, and share models for image analysis; and foster collaborations using regular videoconferencing. During the

Externí odkaz: https://doaj.org/article/3787b1837f31459b8eb3bb03b6acf0fb

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Akademický článek

Detailed Analysis of Simultaneous Renal and Liver Allografts in the Presence of DSA

Autor: Jacqueline G. O’Leary, MD, MPH, Alton B. Farris, MD, Howard M. Gebel, PhD, Sumeet K. Asrani, MD, Medhat Askar, PhD, Vanessa Garcia, BS, George J. Snipes, MD, Denise J. Lo, MD, Stuart J. Knechtle, MD, Goran B. Klintmalm, MD, PhD, Anthony J. Demetris, MD

Publikováno v: Transplantation Direct, Vol 9, Iss 8, p e1500 (2023)

Background. Liver allografts protect renal allografts from the same donor from some, but not all, preformed donor specific alloantibodies (DSA). However, the precise mechanisms of protection and the potential for more subtle alterations/injuries with

Externí odkaz: https://doaj.org/article/c5d023d96c18455eb233152ff43e79d3

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Akademický článek

Perforin inhibition protects from lethal endothelial damage during fulminant viral hepatitis

Autor: M. Welz, S. Eickhoff, Z. Abdullah, J. Trebicka, K. H. Gartlan, J. A. Spicer, A. J. Demetris, H. Akhlaghi, M. Anton, K. Manske, D. Zehn, B. Nieswandt, C. Kurts, J. A. Trapani, P. Knolle, D. Wohlleber, W. Kastenmüller

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)

CD8 T cells can protect the liver from viral infection, but can also result in severe liver damage and organ failure. Here, the authors develop a mouse model reflecting fulminant CD8 T cell mediated viral hepatitis, which occurs in a perforin-depende

Externí odkaz: https://doaj.org/article/a16f075282c8487babc56ea336c15431

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Tissue-resident memory T cell maintenance during antigen persistence requires both cognate antigen and interleukin-15

Autor: Roger Tieu, Qiang Zeng, Daqiang Zhao, Gang Zhang, Neda Feizi, Priyanka Manandhar, Amanda L. Williams, Benjamin Popp, Michelle A. Wood-Trageser, Anthony J. Demetris, J. Yun Tso, Aaron J. Johnson, Lawrence P. Kane, Khodor I. Abou-Daya, Warren D. Shlomchik, Martin H. Oberbarnscheidt, Fadi G. Lakkis

Publikováno v: Science Immunology. 8

Our understanding of tissue-resident memory T (T RM ) cell biology has been largely developed from acute infection models in which antigen is cleared and sterilizing immunity is achieved. Less is known about T RM cells in the context of chronic antig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::00786e2566c98e1c677ee67679c6cc43
https://doi.org/10.1126/sciimmunol.add8454

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Data from Cyclooxygenase-2–Derived Prostaglandin E2 Activates β-Catenin in Human Cholangiocarcinoma Cells: Evidence for Inhibition of These Signaling Pathways by ω3 Polyunsaturated Fatty Acids

Autor: Tong Wu, Anthony J. Demetris, Kumiko Isse, Lihong Xu, Chang Han, Kyu Lim

Cholangiocarcinoma is a highly malignant neoplasm of the biliary tree. It has a high rate of mortality, and currently, there is no effective chemoprevention and treatment. This study was designed to investigate the potential effect of ω3 polyunsatur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::507166902919ee60cb3b105212edc47e
https://doi.org/10.1158/0008-5472.c.6497246

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