Zobrazeno 1 - 10
of 36
pro vyhledávání: '"J, De Los Angeles"'
Autor:
J. De Los Angeles, Victor I. Nikulin, Anish A. Konkar, Richard H. Fertel, Duane D. Miller, Dennis R. Feller, Seoung-Soo Hong
Publikováno v:
Pharmacology. 62:45-55
The biochemical activities of trimetoquinol (TMQ) analogs were evaluated at the human β1- and β3-adrenergic receptor (AR) subtypes expressed in Chinese hamster ovary cells. In radioligand binding assays, the 1-benzyl iodine-substituted analogs exhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb112c7877b9d565e7e5dcb8f526aae0
https://doi.org/10.1159/000056071
https://doi.org/10.1159/000056071
Autor:
Pal L. Vaghy, B.A. Smith, Meri Slavica, Duane D. Miller, J. De Los Angeles, Longping Lei, Dennis R. Feller
Publikováno v:
Journal of Cardiovascular Pharmacology. 31:721-733
Studies have investigated the pharmacologic mechanism of 2-(4'-isothiocyanatobenzyl) imidazoline (IBI) and analogs for interaction with imidazoline receptors (IRs), alpha-adrenergic receptors (alpha-ARs), and calcium channels in cardiovascular muscle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::976d682f284bd22c1f1b5e1dabdae29f
https://doi.org/10.1097/00005344-199805000-00011
https://doi.org/10.1097/00005344-199805000-00011
Autor:
J. De Los Angeles, G. Shams, Duane D. Miller, Victor I. Nikulin, R Mehta, Anish Konkar, Dennis R. Feller
Publikováno v:
Journal of Medicinal Chemistry. 39:3701-3711
A series of trimetoquinol (1, TMQ) analogs were designed and synthesized based on the lead compound 2, a diiodinated analog of trimetoquinol which exhibits improved selectivity for beta 2-versus beta 1-adrenoceptors (AR). To determine the influence o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::022d27a417c143bb4f5593c6854d2ed9
https://doi.org/10.1021/jm960208o
https://doi.org/10.1021/jm960208o
Akademický článek
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Autor:
A A, Konkar, V I, Nikulin, J, De Los Angeles, S S, Hong, R H, Fertel, D D, Miller, D R, Feller
Publikováno v:
Pharmacology. 62(1)
The biochemical activities of trimetoquinol (TMQ) analogs were evaluated at the human beta(1)- and beta(3)-adrenergic receptor (AR) subtypes expressed in Chinese hamster ovary cells. In radioligand binding assays, the 1-benzyl iodine-substituted anal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8808040e647a1b46a8852542d54a1a36
https://pubmed.ncbi.nlm.nih.gov/11150922
https://pubmed.ncbi.nlm.nih.gov/11150922
Publikováno v:
Naunyn-Schmiedeberg's archives of pharmacology. 360(3)
Isothiocyanatobenzyl imidazoline (IBI) produces characteristic slowly developing contraction of many smooth muscle preparations including the circular smooth muscle of the guinea-pig stomach. Changes in the membrane potential were recorded intracellu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a37029f7ffd35fe2d6fa956b640c66d8
https://pubmed.ncbi.nlm.nih.gov/10543437
https://pubmed.ncbi.nlm.nih.gov/10543437
Autor:
A A, Konkar, S S, Vansal, G, Shams, P F, Fraundorfer, W P, Zheng, V I, Nikulin, J, De Los Angeles, R H, Fertel, D D, Miller, D R, Feller
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 291(2)
The beta-adrenoceptor activities of trimetoquinol (TMQ) isomers and selected derivatives were evaluated on human beta-adrenoceptor subtypes expressed in Chinese hamster ovary cells. In cAMP accumulation assays, (-)-TMQ was 214-, 281-, and 776-fold mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e3922a05c86100bfc8cdb53520f59185
https://pubmed.ncbi.nlm.nih.gov/10525112
https://pubmed.ncbi.nlm.nih.gov/10525112
Publikováno v:
Journal of medicinal chemistry. 36(17)
DOM [i.e., 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane] is a 5-HT1C/2 serotonin agonist that exerts stimulus control of behavior in animals. In order to determine if the discriminative stimulus effect of DOM is 5-HT1C- or 5-HT2-mediated, it would
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b424c666096a0ffe7bacad6de4a8b20b
https://pubmed.ncbi.nlm.nih.gov/8355253
https://pubmed.ncbi.nlm.nih.gov/8355253
Conference
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Akademický článek
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