Zobrazeno 1 - 10
of 12 572
pro vyhledávání: '"J, Cox"'
Autor:
Carli M. Stewart, Elizabeth L. Siegler, R. Leo Sakemura, Michelle J. Cox, Truc Huynh, Brooke Kimball, Long Mai, Ismail Can, Claudia Manriquez Roman, Kun Yun, Olivia Sirpilla, James H. Girsch, Ekene Ogbodo, Wazim Mohammed Ismail, Alexandre Gaspar-Maia, Justin Budka, Jenny Kim, Nathalie Scholler, Mike Mattie, Simone Filosto, Saad S. Kenderian
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Durable response to chimeric antigen receptor T (CART) cell therapy remains limited in part due to CART cell exhaustion. Here, we investigate the regulation of CART cell exhaustion with three independent approaches including: a genome-wide C
Externí odkaz:
https://doaj.org/article/9385e305f428439ba7536b1503dee2fa
Publikováno v:
Applied Water Science, Vol 14, Iss 9, Pp 1-18 (2024)
Abstract The emerging pollutant paracetamol (APAP) is one of the most prescribed drugs worldwide. In addition, APAP and its main metabolites, namely, 4-aminophenol (4-AP), hydroquinone (H2Q), benzoquinone (BQ), and 2,5-dihydroxy-1,4-benzoquinone (2,5
Externí odkaz:
https://doaj.org/article/8e7d106968bd4d10b58bcbdba8009040
Autor:
Aarzoo Dhiman, Elad Yom-Tov, Lorenzo Pellis, Michael Edelstein, Richard Pebody, Andrew Hayward, Thomas House, Thomas Finnie, David Guzman, Vasileios Lampos, Virus Watch Consortium, Ingemar J. Cox
Publikováno v:
npj Digital Medicine, Vol 7, Iss 1, Pp 1-10 (2024)
Abstract We propose a method to estimate the household secondary attack rate (hSAR) of COVID-19 in the United Kingdom based on activity on the social media platform X, formerly known as Twitter. Conventional methods of hSAR estimation are resource in
Externí odkaz:
https://doaj.org/article/a96e2a74849649fbba53010cc60558aa
Autor:
T. Uttal, L. M. Hartten, S. J. Khalsa, B. Casati, G. Svensson, J. Day, J. Holt, E. Akish, S. Morris, E. O'Connor, R. Pirazzini, L. X. Huang, R. Crawford, Z. Mariani, Ø. Godøy, J. A. K. Tjernström, G. Prakash, N. Hickmon, M. Maturilli, C. J. Cox
Publikováno v:
Geoscientific Model Development, Vol 17, Pp 5225-5247 (2024)
A large and ever-growing body of geophysical information is measured in campaigns and at specialized observatories as a part of scientific expeditions and experiments. These collections of observed data include many essential climate variables (as de
Externí odkaz:
https://doaj.org/article/b0b6e95974d2487eacffcaf70a19e9f2
Autor:
Z. Mariani, S. M. Morris, T. Uttal, E. Akish, R. Crawford, L. Huang, J. Day, J. Tjernström, Ø. Godøy, L. Ferrighi, L. M. Hartten, J. Holt, C. J. Cox, E. O'Connor, R. Pirazzini, M. Maturilli, G. Prakash, J. Mather, K. Strong, P. Fogal, V. Kustov, G. Svensson, M. Gallagher, B. Vasel
Publikováno v:
Earth System Science Data, Vol 16, Pp 3083-3124 (2024)
The rapid changes occurring in the polar regions require an improved understanding of the processes that are driving these changes. At the same time, increased human activities such as marine navigation, resource exploitation, aviation, commercial fi
Externí odkaz:
https://doaj.org/article/c827a7ccd88a4f35bd429137bb841a17
Autor:
Saba Naghipour, Amanda J. Cox, Joshua J. Fisher, Manuel Plan, Terra Stark, Nic West, Jason N. Peart, John P. Headrick, Eugene F. Du Toit
Publikováno v:
Diabetology & Metabolic Syndrome, Vol 16, Iss 1, Pp 1-16 (2024)
Abstract Background Elevations in the gut metabolite trimethylamine-N-oxide (TMAO) have been linked to cardiovascular and metabolic diseases. Whether elevated TMAO levels reflect early mechanistic involvement or a sequela of evolving disease awaits e
Externí odkaz:
https://doaj.org/article/923a727145144a42a62bb33516abf139
Autor:
Yash Pershad, Taralynn Mack, Hannah Poisner, Yasminka A. Jakubek, Adrienne M. Stilp, Braxton D. Mitchell, Joshua P. Lewis, Eric Boerwinkle, Ruth J. F. Loos, Nathalie Chami, Zhe Wang, Kathleen Barnes, Nathan Pankratz, Myriam Fornage, Susan Redline, Bruce M. Psaty, Joshua C. Bis, Ali Shojaie, Edwin K. Silverman, Michael H. Cho, Jeong H. Yun, Dawn DeMeo, Daniel Levy, Andrew D. Johnson, Rasika A. Mathias, Margaret A. Taub, Donna Arnett, Kari E. North, Laura M. Raffield, April P. Carson, Margaret F. Doyle, Stephen S. Rich, Jerome I. Rotter, Xiuqing Guo, Nancy J. Cox, Dan M. Roden, Nora Franceschini, Pinkal Desai, Alex P. Reiner, Paul L. Auer, Paul A. Scheet, Siddhartha Jaiswal, Joshua S. Weinstock, Alexander G. Bick
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)
Abstract Clonal hematopoiesis (CH) is characterized by the acquisition of a somatic mutation in a hematopoietic stem cell that results in a clonal expansion. These driver mutations can be single nucleotide variants in cancer driver genes or larger st
Externí odkaz:
https://doaj.org/article/1250c0a2d37c41cbad1c671a34d1b82b
Autor:
Jonathan D. Mosley, John P. Shelley, Alyson L. Dickson, Jacy Zanussi, Laura L. Daniel, Neil S. Zheng, Lisa Bastarache, Wei-Qi Wei, Mingjian Shi, Gail P. Jarvik, Elisabeth A. Rosenthal, Atlas Khan, Alborz Sherafati, Iftikhar J. Kullo, Theresa L. Walunas, Joseph Glessner, Hakon Hakonarson, Nancy J. Cox, Dan M. Roden, Stephan G. Frangakis, Brett Vanderwerff, C. Michael Stein, Sara L. Van Driest, Scott C. Borinstein, Xiao-Ou Shu, Matthew Zawistowski, Cecilia P. Chung, Vivian K. Kawai
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Polygenic variation unrelated to disease contributes to interindividual variation in baseline white blood cell (WBC) counts, but its clinical significance is uncharacterized. We investigated the clinical consequences of a genetic predisposit
Externí odkaz:
https://doaj.org/article/aac9cb1b2aa64c909fbdd66e307ed326
Autor:
David Carmona-Berrio, Isabel Adarve-Rengifo, Andrea G. Marshall, Zer Vue, Duane D. Hall, Tyne W. Miller-Fleming, Ky’Era V. Actkins, Heather K. Beasley, Paula M. Almonacid, Pierina Barturen-Larrea, Quinn S. Wells, Marcos G. Lopez, Edgar Garza-Lopez, Dao-Fu Dai, Jianqiang Shao, Kit Neikirk, Frederic T. Billings, IV, John A. Curci, Nancy J. Cox, Vivian Gama, Antentor Hinton, Jr., Jose A. Gomez
Publikováno v:
iScience, Vol 27, Iss 9, Pp 110436- (2024)
Summary: Abdominal and thoracic aortic aneurysms (AAAs, TAAs) remain a major cause of deaths worldwide, in part due to the lack of reliable prognostic markers or early warning signs. Sox6 has been found to regulate renin controlling blood pressure. W
Externí odkaz:
https://doaj.org/article/10fbddafdd5e4e57aba0f987d45fef4e
Autor:
M. Ali Bangash, Cankut Cubuk, Federico Iseppon, Rayan Haroun, Chloe Garcia, Ana P. Luiz, Manuel Arcangeletti, Samuel J. Gossage, Sonia Santana-Varela, James J. Cox, Myles J. Lewis, John N. Wood, Jing Zhao
Publikováno v:
Cell Reports, Vol 43, Iss 8, Pp 114614- (2024)
Summary: The relationship between transcription and protein expression is complex. We identified polysome-associated RNA transcripts in the somata and central terminals of mouse sensory neurons in control, painful (plus nerve growth factor), and pain
Externí odkaz:
https://doaj.org/article/cd2c68f5fde8412d87e766b66f097032