Zobrazeno 1 - 10
of 246
pro vyhledávání: '"J, Coope"'
Autor:
Daniel Lewis, Ka-Loh Li, Mueez Waqar, David J. Coope, Omar N. Pathmanaban, Andrew T. King, Ibrahim Djoukhadar, Sha Zhao, Timothy F. Cootes, Alan Jackson, Xiaoping Zhu
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract A key limitation of current dynamic contrast enhanced (DCE) MRI techniques is the requirement for full-dose gadolinium-based contrast agent (GBCA) administration. The purpose of this feasibility study was to develop and assess a new low GBCA
Externí odkaz:
https://doaj.org/article/7176190d36954bfc8936ef0f28e62558
Autor:
Daniel Lewis, Xiaoping Zhu, David J. Coope, Sha Zhao, Andrew T. King, Timothy Cootes, Alan Jackson, Ka-loh Li
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Accurate vascular input function (VIF) derivation is essential in brain dynamic contrast-enhanced (DCE) MRI. The optimum site for VIF estimation is, however, debated. This study sought to compare VIFs extracted from the internal carotid arte
Externí odkaz:
https://doaj.org/article/f5f0fd600e9044c2aae76b9af6408220
Autor:
Mueez Waqar, Federico Roncaroli, Ibrahim Djoukhadar, Leila Akkari, Claire O'Leary, Lauren Hewitt, Gabriella Forte, Richard Jackson, Eline Hessen, Lisa Withington, William Beasley, Jenny Richardson, Christopher Golby, Philip Whitehurst, Rovel Colaco, Matthew Bailey, Konstantina Karabatsou, Pietro I. D'Urso, Catherine McBain, David J. Coope, Gerben R. Borst
Publikováno v:
Clinical and Translational Radiation Oncology, Vol 39, Iss , Pp 100585- (2023)
Background: Glioblastoma is a high-grade aggressive neoplasm whose outcomes have not changed in decades. In the current treatment pathway, tumour growth continues and remains untreated for several weeks post-diagnosis. Intensified upfront therapy cou
Externí odkaz:
https://doaj.org/article/a0c1d9a40fee4794b2b2595cd357ed30
Autor:
Mueez Waqar, Petra J. Van Houdt, Eline Hessen, Ka-Loh Li, Xiaoping Zhu, Alan Jackson, Mudassar Iqbal, James O’Connor, Ibrahim Djoukhadar, Uulke A. van der Heide, David J. Coope, Gerben R. Borst
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Glioblastoma is a high-grade aggressive neoplasm characterised by significant intra-tumoral spatial heterogeneity. Personalising therapy for this tumour requires non-invasive tools to visualise its heterogeneity to monitor treatment response on a reg
Externí odkaz:
https://doaj.org/article/04932a6b6fd0422188ec508b96921eaa
Autor:
Ka-Loh Li, Daniel Lewis, Xiaoping Zhu, David J. Coope, Ibrahim Djoukhadar, Andrew T. King, Timothy Cootes, Alan Jackson
Publikováno v:
Pharmaceuticals, Vol 16, Iss 9, p 1282 (2023)
This study aimed to develop and evaluate a new DCE-MRI processing technique that combines LEGATOS, a dual-temporal resolution DCE-MRI technique, with multi-kinetic models. This technique enables high spatial resolution interrogation of flow and perme
Externí odkaz:
https://doaj.org/article/2dfb13c82ea24b10b0f0c2b39bad6a9a
Autor:
Daniel Lewis, Damien J. McHugh, Ka-loh Li, Xiaoping Zhu, Catherine Mcbain, Simon K. Lloyd, Alan Jackson, Omar N. Pathmanaban, Andrew T. King, David J. Coope
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Stereotactic radiosurgery (SRS) is an established, effective therapy against vestibular schwannoma (VS). The mechanisms of tumour response are, however, unknown and in this study we sought to evaluate changes in the irradiated VS tumour micr
Externí odkaz:
https://doaj.org/article/abc5338c782846e3994c05568021a4d2
Autor:
Simon Haile, Richard D. Corbett, Tina MacLeod, Steve Bilobram, Duane Smailus, Philip Tsao, Heather Kirk, Helen McDonald, Pawan Pandoh, Miruna Bala, Martin Hirst, Diane Miller, Richard A. Moore, Andrew J. Mungall, Jacquie Schein, Robin J. Coope, Yussanne Ma, Yongjun Zhao, Rob A. Holt, Steven J. Jones, Marco A. Marra
Publikováno v:
BMC Genomics, Vol 18, Iss 1, Pp 1-14 (2017)
Abstract Background RNA-Sequencing (RNA-seq) is now commonly used to reveal quantitative spatiotemporal snapshots of the transcriptome, the structures of transcripts (splice variants and fusions) and landscapes of expressed mutations. However, standa
Externí odkaz:
https://doaj.org/article/0567feec5d9240578c381c3fcd372ebe
Autor:
Simon Haile, Richard D Corbett, Steve Bilobram, Karen Mungall, Bruno M Grande, Heather Kirk, Pawan Pandoh, Tina MacLeod, Helen McDonald, Miruna Bala, Robin J Coope, Richard A Moore, Andrew J Mungall, Yongjun Zhao, Ryan D Morin, Steven J Jones, Marco A Marra
Publikováno v:
PLoS ONE, Vol 14, Iss 10, p e0224578 (2019)
Next generation RNA-sequencing (RNA-seq) is a flexible approach that can be applied to a range of applications including global quantification of transcript expression, the characterization of RNA structure such as splicing patterns and profiling of
Externí odkaz:
https://doaj.org/article/9968d3d49a8b44408b7c991245913ad8
Autor:
Simon Haile, Pawan Pandoh, Helen McDonald, Richard D Corbett, Philip Tsao, Heather Kirk, Tina MacLeod, Martin Jones, Steve Bilobram, Denise Brooks, Duane Smailus, Christian Steidl, David W Scott, Miruna Bala, Martin Hirst, Diane Miller, Richard A Moore, Andrew J Mungall, Robin J Coope, Yussanne Ma, Yongjun Zhao, Rob A Holt, Steven J Jones, Marco A Marra
Publikováno v:
PLoS ONE, Vol 12, Iss 6, p e0178706 (2017)
Curation and storage of formalin-fixed, paraffin-embedded (FFPE) samples are standard procedures in hospital pathology laboratories around the world. Many thousands of such samples exist and could be used for next generation sequencing analysis. Retr
Externí odkaz:
https://doaj.org/article/b12c07735fcc4b01b1aaaa704c35b598
Autor:
Deborah P Merke, Ashwini Mallappa, Wiebke Arlt, Aude Brac De La Perriere, Angelica Linden Hirschberg, Anders Juul, John D C Newell-Price, Colin G Perry, Alessandro Prete, Aled Rees, Nicole Reisch, Monica Stikkelbroeck, Philippe A Touraine, Helen J Coope, John Porter, Richard J Ross
Publikováno v:
Journal of the Endocrine Society. 6:A130-A131
Background Prednisolone and prednisone have a longer plasma elimination half-life after oral administration than hydrocortisone: 2.1 to 3.5 vs ∼1.5hrs1,2. For this reason, prednis(ol)one has been used in Congenital Adrenal Hyperplasia (CAH) by givi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::daf36aa83aeb5e13e4fe4508a294c0e7
https://doi.org/10.1210/jendso/bvac150.266
https://doi.org/10.1210/jendso/bvac150.266