Zobrazeno 1 - 10
of 283
pro vyhledávání: '"J, Chenoweth"'
Autor:
Meghan J. Chenoweth, Lisa Sanderson Cox, Nikki L. Nollen, Jasjit S. Ahluwalia, Neal L. Benowitz, Caryn Lerman, Jo Knight, Rachel F. Tyndale
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Nicotine is inactivated by the polymorphic CYP2A6 enzyme to cotinine and then to 3′hydroxycotinine. The Nicotine Metabolite Ratio (NMR; 3′hydroxycotinine/cotinine) is a heritable nicotine metabolism biomarker, varies with sex and ancestr
Externí odkaz:
https://doaj.org/article/aa651533193346aaa160147f48f32988
Autor:
Alec W. R. Langlois, Ahmed El-Boraie, Jennie G. Pouget, Lisa Sanderson Cox, Jasjit S. Ahluwalia, Koya Fukunaga, Taisei Mushiroda, Jo Knight, Meghan J. Chenoweth, Rachel F. Tyndale
CYP2A6 metabolically inactivates nicotine. Faster CYP2A6 activity is associated with heavier smoking and higher lung cancer risk. The CYP2A6 gene is polymorphic, including functional structural variants (SV) such as gene deletions (CYP2A6*4), duplica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fefaa08f367ed6bac9bf50e0b275975
https://doi.org/10.1038/s10038-023-01148-y
https://doi.org/10.1038/s10038-023-01148-y
Autor:
Antonio J. Landaeta‐Hernández, Mario Castellanos, Marcelo Gil‐Araujo, María E. Peña‐Marcano, Eleazar Soto‐Belloso, Rafaela Dios‐Palomares, D. Owen Rae, Louis F. Archbald, Peter J. Chenoweth
Publikováno v:
Reproduction in Domestic Animals.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d90dea4cac3698d20f6e9fa09a349ed
https://doi.org/10.1111/rda.14356
https://doi.org/10.1111/rda.14356
Akademický článek
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Publikováno v:
Nicotine Tob Res
Introduction Varenicline is the most efficacious drug for smoking cessation; saliva varenicline concentrations can be useful for the evaluation of adherence in smoking cessation trials. Saliva is a useful noninvasive matrix for mail-in specimen colle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59542bffc9b335c3a6942c6ca5560970
https://doi.org/10.1093/ntr/ntab173
https://doi.org/10.1093/ntr/ntab173
Publikováno v:
Hydrology and Earth System Sciences, Vol 18, Iss 6, Pp 2325-2342 (2014)
The water footprint is a consumption-based indicator of water use, referring to the total volume of freshwater used directly and indirectly by a nation or a company, or in the provision of a product or service. Despite widespread enthusiasm for the d
Externí odkaz:
https://doaj.org/article/9ee867b590c64b9aa7fb67832e476ed5
Autor:
Haidy K. Giratallah, Meghan J. Chenoweth, Bernard Le Foll, William J. Kowalczyk, Ahmed El-Boraie, Stephen J. Heishman, Rachel F. Tyndale, Kevin Butler
Publikováno v:
Nicotine Tob Res
Introduction Variation in CYP2A6, the primary enzyme responsible for nicotine metabolism, is associated with nicotine dependence, cigarette consumption, and abstinence outcomes in smokers. The impact of CYP2A6 activity on nicotine reinforcement and t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9655ba69b3ef98cbdd7aec5de3990b0b
https://doi.org/10.1093/ntr/ntab064
https://doi.org/10.1093/ntr/ntab064
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
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Autor:
Neal L. Benowitz, Lisa Sanderson Cox, Rachel F. Tyndale, Nicole L. Nollen, Jo Knight, Michiaki Kubo, Caryn Lerman, Meghan J. Chenoweth, Ahmed El-Boraie, Jennie G. Pouget, Taisei Mushiroda, Koya Fukunaga
Publikováno v:
Clin Pharmacol Ther
Clinical pharmacology and therapeutics, vol 110, iss 4
Clinical pharmacology and therapeutics, vol 110, iss 4
The Nicotine Metabolite Ratio (NMR; 3-hydroxycotinine/cotinine), a highly heritable index of nicotine metabolic inactivation by the CYP2A6 enzyme, is associated with numerous smoking behaviors and diseases, as well as unique cessation outcomes. Howev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3cb05f92a45766c9bdb8624ce823bf4
https://doi.org/10.1002/cpt.2135
https://doi.org/10.1002/cpt.2135
Autor:
Neal L. Benowitz, Jo Knight, Annie R. Peng, Andy Z. X. Zhu, Lisa Sanderson Cox, Meghan J. Chenoweth, Nikki Nollen, Walter Swardfager, Jasjit S. Ahluwalia, Rachel F. Tyndale
BACKGROUND AND AIMS: CYP2B6, a genetically variable enzyme, converts bupropion to its active metabolite hydroxybupropion. CYP2B6 activity and bupropion-aided cessation differ between women and men. The aim of this study was to determine whether genet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1aa11bb6b97af5e2acfa7bfc670649c
https://doi.org/10.1111/add.15742
https://doi.org/10.1111/add.15742